The relationship between Self-Rating of the Effects of alcohol and alcohol challenge results in ninety-eight young men.
paper
Primary
Public
Unavailable
- Authors
- Schuckit, M A; Tipp, J E; Smith, T L; Wiesbeck, G A; Kalmijn, J
- Year
- 1997
- Journal
- Journal of studies on alcohol
- PMID
- 9203121
- DOI
- 10.15288/jsa.1997.58.397
OBJECTIVE: The level of intensity of response to a drug is likely to influence the future pattern of intake of the substance. This article evaluates a simple Self-Rating of the Effects (SRE) of alcohol form, and reports the relationship between a person's estimate of the amounts of alcohol usually required for four possible effects during three different time frames and his subjective feelings reported during an alcohol challenge. METHOD: SRE forms and results of a challenge with 0.9 ml/kg (0.72 g/kg) of ethanol were available for 18 to 29 year old drinking, but not alcohol dependent, men (N = 98). A subset of 40 subjects completed a second SRE form approximately 1 year later. RESULTS: The correlation between the two SRE administration was .82 (p < .0001), and the results on the SRE were internally consistent, with a higher number of drinks associated with more intense alcohol effects. Focusing on the subjective feelings reported at the 60-minute timepoint during the alcohol challenge, 11 of the 12 alcohol effect categories on the SRE correlated in the predicted direction, including eight that were statistically significant. Evaluating all seven timepoints during the drinking experiment, the average number of drinks on the SRE correlated significantly with the Subjective High Assessment Scale (SHAS) total score at all but the final timepoint. Sons of alcoholics and controls demonstrated similar levels of correlation between SRE and alcohol challenge results. Finally, the SRE correctly identified 79% of the individuals whose levels of response to alcohol fell into the lowest third of intensity during the alcohol challenge, and it correctly classified 60% to 67% of the alcohol challenge subjects who did not fall into that low response category. CONCLUSIONS: The SRE is a simple and reliable measure of a person's estimate of the number of drinks required to achieve a response. The form might be helpful in educating people about the intensity of their response to alcohol and might be useful as a point of discussion in curricula focusing on genetic aspects of alcoholism. When alcohol challenges are not possible in a research protocol, the SRE might help identify a less heterogeneous subgroup of individuals at high risk for alcoholism who have a common mechanism increasing their vulnerability.
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|---|---|---|---|---|
| Alcohol insensitivity and the incentive salience of alcohol: Two decades of work relevant to future directions of the addictions neuroclinical assessment. | CofresΓ RU et al. | β | 2025 | β |
| Assessing orbitofrontal cortex volume as a predictor of subjective response to alcohol during early adolescence. | Aguilar LS et al. | β | 2025 | β |
| Body Mass Index Is Inversely Associated With Level of Response to Alcohol: Role of Total Body Water. | Vergeer RR et al. | β | 2025 | β |
| The level of response to alcohol is related to level of se-phosphate in the general population. | Bramness JG et al. | β | 2025 | β |
| Alcohol consumption questionnaire: Scale development in a sample of Mexican American young adults and association with ADH7. | Ehlers CL et al. | β | 2024 | β |
| Objective response to ethanol in essential tremor: results from a standardized ethanol challenge study. | McGurrin P et al. | β | 2024 | β |
| Retrospective self-reports of sensitivity to the effects of alcohol: Trait-like stability and concomitant changes with alcohol involvement. | Kohen CB et al. | β | 2024 | β |
| The effects of simultaneous alcohol and cannabis use on subjective drug effects: A narrative review across methodologies. | Bedillion MF et al. | β | 2024 | β |
| Predicting Alcohol-Related Memory Problems in Older Adults: A Machine Learning Study with Multi-Domain Features. | Kamarajan C et al. | β | 2023 | β |
| Self-report assessment of alcohol sensitivity: An examination of the effects of different probes. | Boness CL et al. | β | 2023 | β |
| The Self-Rated Effects of Alcohol Are Related to Presystemic Metabolism of Alcohol. | Bramness JG et al. | β | 2023 | β |
| Acute sensitization of the P3 event-related potential response to beverage images and the risk for alcohol use disorder. | CofresΓ RU et al. | β | 2022 | β |
| Exploration of the Impact of Combining Risk Phenotypes on the Likelihood of Alcohol Problems in Young Adults. | Kampov-Polevoy A et al. | β | 2022 | β |
| History of Delirium Tremens in AUD Patients in Treatment: Relationship to AUD Severity and Other Factors. | Bramness JG et al. | β | 2022 | β |
| ERK-Directed Phosphorylation of mGlu5 Gates Methamphetamine Reward and Reinforcement in Mouse. | Fultz EK et al. | β | 2021 | β |
| Genome-wide admixture mapping of DSM-IV alcohol dependence, criterion count, and the self-rating of the effects of ethanol in African American populations. | Lai D et al. | β | 2021 | β |
| The motivational valence of methamphetamine relates inversely to subsequent methamphetamine self-administration in female C57BL/6J mice. | Shab G et al. | β | 2021 | β |
| Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans. | Parker CC et al. | β | 2020 | β |
| Genome-wide association studies of the self-rating of effects of ethanol (SRE). | Lai D et al. | β | 2020 | β |
| Comparison of Subjective Responses to Oral and Intravenous Alcohol Administration Under Similar Systemic Exposures. | Plawecki MH et al. | β | 2019 | β |
| Convergent Evidence From Humans and Drosophila melanogaster Implicates the Transcription Factor MEF2B/Mef2 in Alcohol Sensitivity. | Schmitt RE et al. | β | 2019 | β |
| Evidence for incentive salience sensitization as a pathway to alcohol use disorder. | CofresΓ RU et al. | β | 2019 | β |
| Long-Chain Ο-3 Levels Are Associated With Increased Alcohol Sensitivity in a Population-Based Sample of Adolescents. | Edwards AC et al. | β | 2019 | β |
| Predictors of Increases in Alcohol Problems and Alcohol Use Disorders in Offspring in the San Diego Prospective Study. | Schuckit MA et al. | β | 2019 | β |
| Cross-species molecular dissection across alcohol behavioral domains. | Farris SP et al. | β | 2018 | β |
| High-intensity binge drinking is associated with alterations in spontaneous neural oscillations in young adults. | Affan RO et al. | β | 2018 | β |
| Low Inherent Sensitivity to the Intoxicating Effects of Ethanol in Rhesus Monkeys with Low CSF Concentrations of the Serotonin Metabolite 5-Hydroxyindoleacetic Acid. | Wood EK et al. | β | 2018 | β |
| Moderation of alcohol craving reactivity to drinking-related contexts by individual differences in alcohol sensitivity: An ecological investigation. | Trela CJ et al. | β | 2018 | β |
| A Prospective Comparison of How the Level of Response to Alcohol and Impulsivity Relate to Future DSM-IV Alcohol Problems in the COGA Youth Panel. | Schuckit MA et al. | β | 2017 | β |
| Association of Anticipated and Laboratory-Derived Alcohol Stimulation, Sedation, and Reward. | Fridberg DJ et al. | β | 2017 | β |
| Biobehavioral effects of baclofen in anxious alcohol-dependent individuals: a randomized, double-blind, placebo-controlled, laboratory study. | Farokhnia M et al. | β | 2017 | β |
| Differences in reporting of perceived acute effects of alcohol use, marijuana use, and simultaneous alcohol and marijuana use. | Lee CM et al. | β | 2017 | β |
| Effects of drinking patterns on prospective memory performance in college students. | Zamroziewicz M et al. | β | 2017 | β |
| Effects of the serotonin transporter gene, sensitivity of response to alcohol, and parental monitoring on risk for problem alcohol use. | Cope LM et al. | β | 2017 | β |
| Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. | Adkins AE et al. | β | 2017 | β |
| Relationships of Impulsivity and Subjective Response to Alcohol Use and Related Problems. | Berey BL et al. | β | 2017 | β |
| The Role of Social, Familial, and Individual-Level Factors on Multiple Alcohol Use Outcomes During the First Year of University. | Cooke ME et al. | β | 2017 | β |
| Alcohol-related blackouts across 55 weeks of college: Effects of European-American ethnicity, female sex, and low level of response to alcohol. | Schuckit MA et al. | β | 2016 | β |
| A simulation study of the effects of alcohol on driving performance in a Chinese population. | Li YC et al. | β | 2016 | β |
| Homer2 regulates alcohol and stress cross-sensitization. | Quadir SG et al. | β | 2016 | β |
| The natural expression of individual differences in self-reported level of response to alcohol during ecologically assessed drinking episodes. | Trela CJ et al. | β | 2016 | β |
| Prepartying, drinking games, and extreme drinking among college students: a daily-level investigation. | Fairlie AM et al. | β | 2015 | β |
| Alcohol cues, approach bias, and inhibitory control: applying a dual process model of addiction to alcohol sensitivity. | Fleming KA et al. | β | 2014 | β |
| Does hangover influence the time to next drink? An investigation using ecological momentary assessment. | Epler AJ et al. | β | 2014 | β |
| Effect of sex on ethanol consumption and conditioned taste aversion in adolescent and adult rats. | Schramm-Sapyta NL et al. | β | 2014 | β |
| Mesocorticolimbic monoamine correlates of methamphetamine sensitization and motivation. | Lominac KD et al. | β | 2014 | β |
| Predictors of subgroups based on maximum drinks per occasion over six years for 833 adolescents and young adults in COGA. | Schuckit MA et al. | β | 2014 | β |
| The patterns of drug and alcohol use and associated problems over 30 years in 397 men. | Schuckit MA et al. | β | 2014 | β |
| Dimensions of parental alcohol use/problems and offspring temperament, externalizing behaviors, and alcohol use/problems. | Kendler KS et al. | β | 2013 | β |
| Genetic studies of acute tolerance, rapid tolerance, and drinking in the dark in the LXS recombinant inbred strains. | Radcliffe RA et al. | β | 2013 | β |
| Relationships among independent major depressions, alcohol use, and other substance use and related problems over 30 years in 397 families. | Schuckit MA et al. | β | 2013 | β |
| Stability of scores and correlations with drinking behaviors over 15 years for the Self-Report of the Effects of Alcohol Questionnaire. | Schuckit MA et al. | β | 2013 | β |
| Comparison across two generations of prospective models of how the low level of response to alcohol affects alcohol outcomes. | Schuckit MA et al. | β | 2012 | β |
| Heritability of level of response and association with recent drinking history in nonalcohol-dependent drinkers. | Kalu N et al. | β | 2012 | β |
| Low sensitivity to alcohol: relations with hangover occurrence and susceptibility in an ecological momentary assessment investigation. | Piasecki TM et al. | β | 2012 | β |
| Structuring a college alcohol prevention program on the low level of response to alcohol model: a pilot study. | Schuckit MA et al. | β | 2012 | β |
| What do you mean "drunk"? Convergent validation of multiple methods of mapping alcohol expectancy memory networks. | Reich RR et al. | β | 2012 | β |
| Alcohol attenuates activation in the bilateral anterior insula during an emotional processing task: a pilot study. | Padula CB et al. | β | 2011 | β |
| ALDH2 and ADH1B interactions in retrospective reports of low-dose reactions and initial sensitivity to alcohol in Asian American college students. | Luczak SE et al. | β | 2011 | β |
| Modest abuse-related subjective effects of zolpidem in drug-naive volunteers. | Licata SC et al. | β | 2011 | β |
| Predictors and outcomes of variability in subjective alcohol intoxication among college students: an event-level analysis across 4 years. | Quinn PD et al. | β | 2011 | β |
| Self-Rating of the Effects of Alcohol (SRE): Predictive utility and reliability across interview and self-report administrations. | Ray LA et al. | β | 2011 | β |
| Testing a level of response to alcohol-based model of heavy drinking and alcohol problems in 1,905 17-year-olds. | Schuckit MA et al. | β | 2011 | β |
| The effect of naltrexone on alcohol's stimulant properties and self-administration behavior in social drinkers: influence of gender and genotype. | Setiawan E et al. | β | 2011 | β |
| Ups and downs of alcohol use among first-year college students: Number of drinks, heavy drinking, and stumble and pass out drinking days. | Maggs JL et al. | β | 2011 | β |
| Acute ethanol effects on brain activation in low- and high-level responders to alcohol. | Trim RS et al. | β | 2010 | β |
| Aversive effects of ethanol in adolescent versus adult rats: potential causes and implication for future drinking. | Schramm-Sapyta NL et al. | β | 2010 | β |
| Comparing structural equation models that use different measures of the level of response to alcohol. | Schuckit MA et al. | β | 2010 | β |
| Genome-wide scan for self-rating of the effects of alcohol in American Indians. | Ehlers CL et al. | β | 2010 | β |
| Human and laboratory rodent low response to alcohol: is better consilience possible? | Crabbe JC et al. | β | 2010 | β |
| Human variation in alcohol response is influenced by variation in neuronal signaling genes. | Joslyn G et al. | β | 2010 | β |
| Specificity of P3 event-related potential reactivity to alcohol cues in individuals low in alcohol sensitivity. | Bartholow BD et al. | β | 2010 | β |
| Subjective effects to marijuana associated with marijuana use in community and clinical subjects. | Zeiger JS et al. | β | 2010 | β |
| An examination of subjective response to alcohol in African Americans. | Pedersen SL et al. | β | 2009 | β |
| Associations among GABRG1, level of response to alcohol, and drinking behaviors. | Ray LA et al. | β | 2009 | β |
| The overlap in predicting alcohol outcome for two measures of the level of response to alcohol. | Schuckit MA et al. | β | 2009 | β |
| The relationships of the level of response to alcohol and additional characteristics to alcohol use disorders across adulthood: a discrete-time survival analysis. | Trim RS et al. | β | 2009 | β |
| Age at first drink and the first incidence of adult-onset DSM-IV alcohol use disorders. | Dawson DA et al. | β | 2008 | β |
| Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans. | Joslyn G et al. | β | 2008 | β |
| Density of familial alcoholism and its effects on alcohol use and problems in college students. | Capone C et al. | β | 2008 | β |
| Does lower response to alcohol explain the high co-morbidity between bipolar disorder and alcohol dependence? | Le Strat Y et al. | β | 2008 | β |
| Ethnic differences in level of response to alcohol between Chinese Americans and Korean Americans. | Duranceaux NC et al. | β | 2008 | β |
| Subjective alcohol effects and drinking behavior: the relative influence of early response and acquired tolerance. | Morean ME et al. | β | 2008 | β |
| The performance of elements of a 'level of response to alcohol'-based model of drinking behaviors in 13-year-olds. | Schuckit MA et al. | β | 2008 | β |
| The self-rating of the effects of alcohol questionnaire as a predictor of alcohol-related outcomes in 12-year-old subjects. | Schuckit MA et al. | β | 2008 | β |
| Alcohol attenuates load-related activation during a working memory task: relation to level of response to alcohol. | Paulus MP et al. | β | 2006 | β |
| Intoxicated behavioral disinhibition and the heart rate response to alcohol. | Assaad JM et al. | β | 2006 | β |
| Low level of response to alcohol as associated with serotonin transporter genotype and high alcohol intake in adolescents. | Hinckers AS et al. | β | 2006 | β |
| A cross-generational comparison of alcohol challenges at about age 20 in 40 father-offspring pairs. | Schuckit MA et al. | β | 2005 | β |
| Alcoholism: the dissection for endophenotypes. | Hines LM et al. | β | 2005 | β |
| Genetic associations of alcohol dehydrogenase with alcohol use disorders and endophenotypes in white college students. | Wall TL et al. | β | 2005 | β |
| The Irish Affected Sib Pair Study of Alcohol Dependence: study methodology and validation of diagnosis by interview and family history. | Prescott CA et al. | β | 2005 | β |
| Findings across subgroups regarding the level of response to alcohol as a risk factor for alcohol use disorders: a college population of women and Latinos. | Schuckit MA et al. | β | 2004 | β |
| Heightened heart rate response to alcohol intoxication is associated with a reward-seeking personality profile. | Brunelle C et al. | β | 2004 | β |
| The search for genes contributing to the low level of response to alcohol: patterns of findings across studies. | Schuckit MA et al. | β | 2004 | β |
| Alcohol promotes dopamine release in the human nucleus accumbens. | Boileau I et al. | β | 2003 | β |
| Effects of alcohol consumption and alcohol susceptibility on cognition: a psychophysiological examination. | Bartholow BD et al. | β | 2003 | β |
| Level of response to alcohol measured on the self-rating of the effects of alcohol questionnaire in a group of 40-year-old women. | Schuckit MA et al. | β | 2003 | β |
| The search for genes related to a low-level response to alcohol determined by alcohol challenges. | Wilhelmsen KC et al. | β | 2003 | β |
| A comparison of two measures of low response to alcohol among heavy drinking male college students: implications for indicated prevention. | Daugherty R et al. | β | 2002 | β |
| ADH2 and alcohol-related phenotypes in Ashkenazic Jewish American college students. | Shea SH et al. | β | 2001 | β |
| A genome-wide search for genes that relate to a low level of response to alcohol. | Schuckit MA et al. | β | 2001 | β |
| A measure of the intensity of response to alcohol in a military population. | Schuckit MA et al. | β | 2001 | β |
| An integrative approach for studying the etiology of alcoholism and other addictions. | Jacob T et al. | β | 2001 | β |
| Biological phenotypes associated with individuals at high risk for developing alcohol-related disorders. Part 2. | Schuckit MA | β | 2000 | β |
| Genetics of the risk for alcoholism. | Schuckit MA | β | 2000 | β |
| Issues in the recovery of physicians from addictive illnesses. | Mansky PA | β | 1999 | β |
| The Self-Rating of the Effects of alcohol (SRE) form as a retrospective measure of the risk for alcoholism. | Schuckit MA et al. | β | 1997 | β |