Case-control and within-family tests for an association between conduct disorder and DAT1.
- Authors
- Schulz-Heik, R Jay; Maentz, Sarah K; Rhee, Soo Hyun; Gelhorn, Heather L; Young, Susan E; Timberlake, David S; Smolen, Andrew; Stetler, Gary L; Sakai, Joseph T; Crowley, Thomas J
- Year
- 2008
- Journal
- Psychiatric genetics
- PMID
- 18197081
- DOI
- 10.1097/YPG.0b013e3282ef48c8
BACKGROUND: Conduct disorder (CD) is characterized by a persistent pattern of violating age-appropriate norms and the rights of others, and is one of the most frequently diagnosed disorders among children. CD is moderately heritable, but we know of no reliable associations with specific genes. Evidence suggests that a variable number tandem repeat polymorphism of the dopamine transporter (DAT1) gene may be associated with externalizing behavior in children. OBJECTIVE: To test for an association between the DAT1 gene and CD. DESIGN: Case-control analyses and a transmission disequilibrium test (TDT) were conducted. SETTING/PARTICIPANTS: Cases were (n=210) adolescents enrolled in a Colorado treatment program for conduct and substance use problems. Controls included adolescents matched to the probands in the treatment program and their siblings (n=162). The TDT was conducted using case families in which DNA from both parents was available (95 trios). RESULTS: The case-control analysis of the full sample did not result in a significant association [chi2 (2,372)=0.13, P=0.94]. Cases with early-onset conduct problems had slightly more 10-repeat alleles than controls, although this difference was not significant [chi2 (2,264)=2.19, P=0.33, 9/10 odds ratio (OR)=1.58, 10/10 OR=2.14]. The TDT also did not result in a significant association [chi2(1)=0.12, P=0.94]. CONCLUSION: Results did not support an association between this polymorphism of the DAT1 gene and CD in adolescents.
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In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Mesocorticolimbic dopamine functioning in primary psychopathy: A source of within-group heterogeneity. | Yildirim BO et al. | — | 2015 | → |
| Genome-wide association study of conduct disorder symptomatology. | Dick DM et al. | — | 2011 | → |
| Interactions between early parenting and a polymorphism of the child's dopamine transporter gene in predicting future child conduct disorder symptoms. | Lahey BB et al. | — | 2011 | → |
| Limited associations of dopamine system genes with alcohol dependence and related traits in the Irish Affected Sib Pair Study of Alcohol Dependence (IASPSAD). | Hack LM et al. | — | 2011 | → |
| Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood. | Nemoda Z et al. | — | 2011 | → |
| Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives. | Sakai JT et al. | — | 2010 | → |