Cannabinoid addiction: behavioral models and neural correlates.
paper
Cited
Public
Unavailable
- Authors
- Maldonado, Rafael; RodrΓguez de Fonseca, Fernando
- Year
- 2002
- Journal
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- PMID
- 11978807
- DOI
- 10.1523/JNEUROSCI.22-09-03326.2002
- PMCID
- PMC6758395
The use of cannabis sativa preparations as recreational drugs can be traced back to the earliest civilizations. However, animal models of cannabinoid addiction allowing the exploration of neural correlates of cannabinoid abuse have been developed only recently. We review these models and the role of the CB1 cannabinoid receptor, the main target of natural cannabinoids, and its interaction with opioid and dopamine transmission in reward circuits. Extensive reviews on the molecular basis of cannabinoid action are available elsewhere (Piomelli et al., 2000; Schlicker and Kathmann, 2001).
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