Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice.
paper
Cited
Public
Unavailable
- Authors
- Caine, S Barak; Thomsen, Morgane; Gabriel, Kara I; Berkowitz, Jill S; Gold, Lisa H; Koob, George F; Tonegawa, Susumu; Zhang, Jianhua; Xu, Ming
- Year
- 2007
- Journal
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- PMID
- 18045908
- DOI
- 10.1523/JNEUROSCI.2284-07.2007
- PMCID
- PMC2747091
Evidence suggests a critical role for dopamine in the reinforcing effects of cocaine in rats and primates. However, self-administration has been less often studied in the mouse species, and, to date, "knock-out" of individual dopamine-related genes in mice has not been reported to reduce the reinforcing effects of cocaine. We studied the dopamine D1 receptor and cocaine self-administration in mice using a combination of gene-targeted mutation and pharmacological tools. Two cohorts with varied breeding and experimental histories were tested, and, in both cohorts, there was a significant decrease in the number of D1 receptor knock-out mice that met criteria for acquisition of cocaine self-administration (2 of 23) relative to wild-type mice (27 of 32). After extinction of responding with saline self-administration, dose-response studies showed that cocaine reliably and dose dependently maintained responding greater than saline in all wild-type mice but in none of the D1 receptor knock-out mice. The D1-like agonist SKF 82958 (2,3,4,5,-tetrahydro-6-chloro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrobromide) and the D2-like agonist quinelorane both functioned as positive reinforcers in wild-type mice but not in D1 receptor mutant mice, whereas food and intravenous injections of the opioid agonist remifentanil functioned as positive reinforcers in both genotypes. Finally, pretreatment with the D1-like antagonist SCH 23390 [R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-01] produced surmountable antagonism of the reinforcing effects of cocaine in the commonly used strain C57BL/6J. We conclude that D1 receptor knock-out mice do not reliably self-administer cocaine and that the D1 receptor is critical for the reinforcing effects of cocaine and other dopamine agonists, but not food or opioids, in mice.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. | 2012 | 22358648 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Cocaine-Induced Immediate-Early Gene Expression in the Nucleus Accumbens: Roles of Separate cAMP Sensors. | Zhang HY et al. | β | 2026 | β |
| Pitolisant Inhibits Alcohol Drinking and Improves Withdrawal Negative Affect Through Lateral Habenula Histaminergic Signaling in Mice. | Zhao Y et al. | β | 2026 | β |
| Role of miRNAs from mesenchymal stem cell-derived extracellular vesicles in neuroinflammation and behavioral impairments induced by chronic alcohol consumption in female mice. | Mellado S et al. | β | 2026 | β |
| Cocaine-induced immediate-early gene expression in the nucleus accumbens: roles of separate cAMP sensors | Zhang H et al. | β | 2025 | β |
| Epigenetic regulation of cocaine intake through dopaminergic control of cholinergic interneurons in male mice. | Lewis RG et al. | β | 2025 | β |
| The Implementation of the Biopsychosocial Model: Individuals With Alcohol Use Disorder and Post-Traumatic Stress Disorder. | Hinostroza F et al. | β | 2025 | β |
| The mesocorticolimbic system in stimulant use disorder. | London ED et al. | β | 2025 | β |
| Conditional deletion of the AMPA-GluA1 and NMDA-GluN1 receptor subunit genes in midbrain D1 neurons does not alter cocaine reward in mice. | Borruto AM et al. | β | 2024 | β |
| Dopamine D<sub>1</sub>-Like Receptor-Mediated Insurmountable Blockade of the Reinforcing Effects of Cocaine in Rats. | Hiranita T et al. | β | 2024 | β |
| Isradipine, an L-type calcium channel blocker, attenuates cocaine effects in mice by reducing central glutamate release. | Lima ALD et al. | β | 2024 | β |
| Mirtazapine decreased cocaine-induced <i>c-fos</i> expression and dopamine release in rats. | Barbosa-MΓ©ndez S et al. | β | 2024 | β |
| Nicotine and fluoxetine alter adolescent dopamine-mediated behaviors via 5-HT<sub>1A</sub> receptor activation. | Yuan M et al. | β | 2024 | β |
| Nucleus accumbens neuronal ensembles vary with cocaine reinforcement in male and female rats. | Sortman BW et al. | β | 2024 | β |
| The nucleus accumbens in reward and aversion processing: insights and implications. | Xu Y et al. | β | 2024 | β |
| cAMP-mediated upregulation of HCN channels in VTA dopamine neurons promotes cocaine reinforcement. | Mu L et al. | β | 2023 | β |
| High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling. | Tyler J et al. | β | 2023 | β |
| A Dopamine D<sub>1</sub> Agonist Versus Methylphenidate in Modulating Prefrontal Cortical Working Memory. | Yang Y et al. | β | 2022 | β |
| Alcohol Use Disorder: Neurobiology and Therapeutics. | Yang W et al. | β | 2022 | β |
| Cholinergic and dopaminergic-mediated motivated behavior in healthy states and in substance use and mood disorders. | Nunes EJ et al. | β | 2022 | β |
| Dopamine D1-like receptor blockade and stimulation decreases operant responding for nicotine and food in male and female rats. | Chellian R et al. | β | 2022 | β |
| An Integrated Mechanistic Model of Mindfulness-Oriented Recovery Enhancement for Opioid-Exposed Mother-Infant Dyads. | Reese SE et al. | β | 2021 | β |
| An optimized procedure for robust volitional cocaine intake in mice. | LΓ³pez AJ et al. | β | 2021 | β |
| Dopamine D1 and D2 receptors are distinctly associated with rest-activity rhythms and drug reward. | Zhang R et al. | β | 2021 | β |
| Effects of Ξ²-Phenylethylamine on Psychomotor, Rewarding, and Reinforcing Behaviors and Affective State: The Role of Dopamine D1 Receptors. | Ryu IS et al. | β | 2021 | β |
| Identification of the Risk Genes Associated With Vulnerability to Addiction: Major Findings From Transgenic Animals. | Jordan CJ et al. | β | 2021 | β |
| Regulation of dopamine-dependent transcription and cocaine action by Gadd45b. | Zipperly ME et al. | β | 2021 | β |
| The role of serotoninergic system in psychostimulant effects. | Taracha E | β | 2021 | β |
| Delineating the Psychic Structure of Substance Use and Addictions, from Neurobiology to Clinical Implications: Ten Years Later. | Pani PP et al. | β | 2020 | β |
| In vivo reduction of striatal D1R by RNA interference alters expression of D1R signaling-related proteins and enhances methamphetamine addiction in male rats. | Kreisler AD et al. | β | 2020 | β |
| Involvement of the endogenous opioid system in the beneficial influence of physical exercise on amphetamine-induced addiction parameters. | Rosa HZ et al. | β | 2020 | β |
| Psychostimulant-Induced Adaptations in Nucleus Accumbens Glutamatergic Transmission. | Wright WJ et al. | β | 2020 | β |
| SCH23390 Reduces Methamphetamine Self-Administration and Prevents Methamphetamine-Induced Striatal LTD. | Avchalumov Y et al. | β | 2020 | β |
| Sex-Specific Role for Egr3 in Nucleus Accumbens D2-Medium Spiny Neurons Following Long-Term Abstinence From Cocaine Self-administration. | Engeln M et al. | β | 2020 | β |
| (-)-Stepholidine blocks expression, but not development, of cocaine conditioned place preference in rats. | Bennett A et al. | β | 2020 | β |
| Alternation in dopamine D<sub>2</sub>-like and metabotropic glutamate type 5 receptor density caused by differing housing conditions during abstinence from cocaine self-administration in rats. | Frankowska M et al. | β | 2019 | β |
| D1 receptor hypersensitivity in mice with low striatal D2 receptors facilitates select cocaine behaviors. | Dobbs LK et al. | β | 2019 | β |
| Dopamine and addiction: what have we learned from 40Β years of research. | Solinas M et al. | β | 2019 | β |
| Glucagon-Like Peptide-1 Receptor Agonist Treatment Does Not Reduce Abuse-Related Effects of Opioid Drugs. | Bornebusch AB et al. | β | 2019 | β |
| Male and female mice develop escalation of heroin intake and dependence following extended access. | Towers EB et al. | β | 2019 | β |
| Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders. | Burns JA et al. | β | 2019 | β |
| NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control. | Sutton LP et al. | β | 2019 | β |
| Sex-Specific Gene Expression in the Mouse Nucleus Accumbens Before and After Cocaine Exposure. | LaRese TP et al. | β | 2019 | β |
| The Ankyrin Repeat and Kinase Domain Containing 1 Gene Polymorphism (<i>ANKK1</i><i>Taq1A</i>) and Personality Traits in Addicted Subjects. | Grzywacz A et al. | β | 2019 | β |
| The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice. | Bernardi RE et al. | β | 2019 | β |
| Transient Chemogenetic Inhibition of D1-MSNs in the Dorsal Striatum Enhances Methamphetamine Self-Administration. | Oliver RJ et al. | β | 2019 | β |
| Transient receptor potential vanilloid 1 mediates cocaine reinstatement via the D1 dopamine receptor in the nucleus accumbens. | You IJ et al. | β | 2019 | β |
| Variability in the Drug Response of M<sub>4</sub> Muscarinic Receptor Knockout Mice During Day and Night Time. | Valuskova P et al. | β | 2019 | β |
| Effects of muscarinic M<sub>1</sub> and M<sub>4</sub> acetylcholine receptor stimulation on extinction and reinstatement of cocaine seeking in male mice, independent of extinction learning. | Stoll K et al. | β | 2018 | β |
| Alterations in Striatal Circuits Underlying Addiction-Like Behaviors. | Kim HJ et al. | β | 2017 | β |
| Current Concepts on the Physiopathological Relevance of Dopaminergic Receptors. | Ledonne A et al. | β | 2017 | β |
| Individual differences in the neuropsychopathology of addiction. | George O et al. | β | 2017 | β |
| Interactions of Cathinone NPS with Human Transporters and Receptors in Transfected Cells. | Simmler LD et al. | β | 2017 | β |
| Selective Vulnerability of Striatal D2 versus D1 Dopamine Receptor-Expressing Medium Spiny Neurons in HIV-1 Tat Transgenic Male Mice. | Schier CJ et al. | β | 2017 | β |
| Single cocaine exposure does not alter striatal pre-synaptic dopamine function in mice: an [<sup>18</sup> F]-FDOPA PET study. | Bonsall DR et al. | β | 2017 | β |
| The Role of Working Memory for Cognitive Control in Anorexia Nervosa versus Substance Use Disorder. | Brooks SJ et al. | β | 2017 | β |
| The serotonin 5-HT<sub>2C</sub> receptor and the non-addictive nature of classic hallucinogens. | Canal CE et al. | β | 2017 | β |
| Advances and challenges in pharmacotherapeutics for amphetamine-type stimulants addiction. | Cao DN et al. | β | 2016 | β |
| Effects of dopamine D1-like and D2-like antagonists on cocaine discrimination in muscarinic receptor knockout mice. | Thomsen M et al. | β | 2016 | β |
| Enhanced sensitivity to drugs of abuse and palatable foods following maternal overnutrition. | Peleg-Raibstein D et al. | β | 2016 | β |
| Epigenetics and addiction. | Cadet JL et al. | β | 2016 | β |
| Neurobiology of addiction: a neurocircuitry analysis. | Koob GF et al. | β | 2016 | β |
| Presynaptic G Protein-Coupled Receptors: Gatekeepers of Addiction? | Johnson KA et al. | β | 2016 | β |
| Reappraising striatal D1- and D2-neurons in reward and aversion. | Soares-Cunha C et al. | β | 2016 | β |
| Theory of Connectivity: Nature and Nurture of Cell Assemblies and Cognitive Computation. | Li M et al. | β | 2016 | β |
| Adaptations of presynaptic dopamine terminals induced by psychostimulant self-administration. | Siciliano CA et al. | β | 2015 | β |
| Differential Roles for Dopamine D1-Like and D2-Like Receptors in Mediating the Reinforcing Effects of Cocaine: Convergent Evidence from Pharmacological and Genetic Studies. | Hiranita T et al. | β | 2015 | β |
| Loss of feedback inhibition via D2 autoreceptors enhances acquisition of cocaine taking and reactivity to drug-paired cues. | Holroyd KB et al. | β | 2015 | β |
| Post-transcriptional regulation of dopamine D1 receptor expression in caudate-putamen of cocaine-sensitized mice. | TobΓ³n KE et al. | β | 2015 | β |
| The Brain on Drugs: From Reward to Addiction. | Volkow ND et al. | β | 2015 | β |
| Convergence of dopamine and glutamate signaling onto striatal ERK activation in response to drugs of abuse. | Cahill E et al. | β | 2014 | β |
| Diminished role of dopamine D1-receptor signaling with the development of an addicted phenotype in rats. | RamΓ΄a CP et al. | β | 2014 | β |
| Dopamine D1 and D3 receptors mediate reconsolidation of cocaine memories in mouse models of drug self-administration. | Yan Y et al. | β | 2014 | β |
| Extended access oxycodone self-administration and neurotransmitter receptor gene expression in the dorsal striatum of adult C57BL/6Β J mice. | Zhang Y et al. | β | 2014 | β |
| Preadolescent drd1-EGFP mice exhibit cocaine-induced behavioral sensitization. | TobΓ³n KE et al. | β | 2014 | β |
| Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers. | Volkow ND et al. | β | 2014 | β |
| Tesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: dopamine transporter occupancy as measured by PET. | Appel L et al. | β | 2014 | β |
| Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΞFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell. | Robison AJ et al. | β | 2013 | β |
| Dopamine D1 receptor gene variation modulates opioid dependence risk by affecting transition to addiction. | Zhu F et al. | β | 2013 | β |
| Dopamine D(3) receptor deletion or blockade attenuates cocaine-induced conditioned place preference in mice. | Song R et al. | β | 2013 | β |
| Dopamine signaling in reward-related behaviors. | Baik JH | β | 2013 | β |
| Genetic reconstruction of dopamine D1 receptor signaling in the nucleus accumbens facilitates natural and drug reward responses. | Gore BB et al. | β | 2013 | β |
| Histamine Hβ receptors, the complex interaction with dopamine and its implications for addiction. | Ellenbroek BA | β | 2013 | β |
| L-isocorypalmine reduces behavioral sensitization and rewarding effects of cocaine in mice by acting on dopamine receptors. | Xu W et al. | β | 2013 | β |
| Chronic cocaine self-administration modulates ERK1/2 and CREB responses to dopamine receptor agonists in striatal slices. | Hoffmann HM et al. | β | 2012 | β |
| Cognitive control and the dopamine Dβ-like receptor: a dimensional understanding of addiction. | Groman SM et al. | β | 2012 | β |
| Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: selective inhibitors of dopamine Dβ receptor. | Qian W et al. | β | 2012 | β |
| Drug specificity in extended access cocaine and heroin self-administration. | Lenoir M et al. | β | 2012 | β |
| Genetics of dopamine receptors and drug addiction. | Gorwood P et al. | β | 2012 | β |
| Increased vulnerability to cocaine in mice lacking dopamine D3 receptors. | Song R et al. | β | 2012 | β |
| Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA. | Padgett CL et al. | β | 2012 | β |
| Role of the dopaminergic system in the acquisition, expression and reinstatement of MDMA-induced conditioned place preference in adolescent mice. | Vidal-Infer A et al. | β | 2012 | β |
| Salt appetite and addiction--unholy twins? | Ritz E | β | 2012 | β |
| The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. | Derringer J et al. | β | 2012 | β |
| (3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction. | Lindsley CW et al. | β | 2011 | β |
| A behavioral genetics approach to understanding D1 receptor involvement in phasic dopamine signaling. | Wall VZ et al. | β | 2011 | β |
| Activation of dopamine D3 receptors inhibits reward-related learning induced by cocaine. | Kong H et al. | β | 2011 | β |
| Basal Ganglia disorders associated with imbalances in the striatal striosome and matrix compartments. | Crittenden JR et al. | β | 2011 | β |
| Cocaine-induced plasticity in the nucleus accumbens is cell specific and develops without prolonged withdrawal. | Dobi A et al. | β | 2011 | β |
| Enhanced sucrose and cocaine self-administration and cue-induced drug seeking after loss of VGLUT2 in midbrain dopamine neurons in mice. | AlsiΓΆ J et al. | β | 2011 | β |
| Exploring mechanisms underlying extinction of cue-elicited cocaine seeking. | Kong H et al. | β | 2011 | β |
| False positive in the intravenous drug self-administration test in C57BL/6J mice. | Thomsen M et al. | β | 2011 | β |
| Psychomotor stimulant effects of cocaine in rats and 15 mouse strains. | Thomsen M et al. | β | 2011 | β |
| Psychomotor stimulation by dopamine Dβ-like but not Dβ-like agonists in most mouse strains. | Thomsen M et al. | β | 2011 | β |
| Ras-ERK Signaling in Behavior: Old Questions and New Perspectives. | Fasano S et al. | β | 2011 | β |
| Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite. | Liedtke WB et al. | β | 2011 | β |
| Stimulant abuse: pharmacology, cocaine, methamphetamine, treatment, attempts at pharmacotherapy. | Ciccarone D | β | 2011 | β |
| Striatal signal transduction and drug addiction. | Philibin SD et al. | β | 2011 | β |
| The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons. | Lobo MK et al. | β | 2011 | β |
| Action of modafinil--increased motivation via the dopamine transporter inhibition and D1 receptors? | Young JW et al. | β | 2010 | β |
| Behavioral and morphological responses to cocaine require kalirin7. | Kiraly DD et al. | β | 2010 | β |
| Depression and the role of genes involved in dopamine metabolism and signalling. | Opmeer EM et al. | β | 2010 | β |
| Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behavior. | Hikida T et al. | β | 2010 | β |
| Dopamine D1 and D3 receptors are differentially involved in cue-elicited cocaine seeking. | Chen L et al. | β | 2010 | β |
| Dopamine D1 and N-methyl-D-aspartate receptors and extracellular signal-regulated kinase mediate neuronal morphological changes induced by repeated cocaine administration. | Ren Z et al. | β | 2010 | β |
| Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation. | Brown MT et al. | β | 2010 | β |
| Locomotion and self-administration induced by cocaine in 129/OlaHsd mice lacking galanin. | Brabant C et al. | β | 2010 | β |
| Neurocircuitry of addiction. | Koob GF et al. | β | 2010 | β |
| Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). | Olsen CM et al. | β | 2010 | β |
| p-Hydroxyamphetamine causes prepulse inhibition disruptions in mice: contribution of dopamine neurotransmission. | Onogi H et al. | β | 2010 | β |
| Reinforcer-dependent enhancement of operant responding in opioid-withdrawn rats. | Cooper ZD et al. | β | 2010 | β |
| Transgenic mice in the study of drug addiction and the effects of psychostimulant drugs. | Sora I et al. | β | 2010 | β |
| Cocaine effects on dopamine and NMDA receptors interactions in the striatum of Fischer rats. | Sun WL et al. | β | 2009 | β |
| Dopamine D1 receptors in cocaine dependence measured with PET and the choice to self-administer cocaine. | Martinez D et al. | β | 2009 | β |
| Dopamine enables in vivo synaptic plasticity associated with the addictive drug nicotine. | Tang J et al. | β | 2009 | β |
| Dopamine receptors in the learning, memory and drug reward circuitry. | Dalley JW et al. | β | 2009 | β |
| Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice. | Thomsen M et al. | β | 2009 | β |
| Genetics of dopamine receptors and drug addiction: a comprehensive review. | Le Foll B et al. | β | 2009 | β |
| Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter. | Thomsen M et al. | β | 2009 | β |
| Localized low-level re-expression of high-affinity mesolimbic nicotinic acetylcholine receptors restores nicotine-induced locomotion but not place conditioning. | Mineur YS et al. | β | 2009 | β |
| Operant sensation seeking engages similar neural substrates to operant drug seeking in C57 mice. | Olsen CM et al. | β | 2009 | β |
| Correlating human and animal studies of cocaine abuse and gene expression. | Lull ME et al. | β | 2008 | β |
| Fos regulates neuronal activity in the nucleus accumbens. | Hu XT et al. | β | 2008 | β |
| Genes and molecules that can potentiate or attenuate psychostimulant dependence: relevance of data from animal models to human addiction. | Niwa M et al. | β | 2008 | β |
| Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence. | Smith RJ et al. | β | 2008 | β |