Brain atrophy in chronic alcoholic patients: a quantitative pathological study.
paper
Cited
Public
Unavailable
- Authors
- Harper, C; Kril, J
- Year
- 1985
- Journal
- Journal of neurology, neurosurgery, and psychiatry
- PMID
- 3981189
- DOI
- 10.1136/jnnp.48.3.211
- PMCID
- PMC1028252
There are essentially no objective neuropathological data on brain atrophy in chronic alcoholic patients despite numerous neuroradiological studies which show a high incidence of shrinkage or atrophy. Therefore measurements were made of the intracranial volume (ICV) and brain volume (BV) in a necropsy study of 25 chronic alcoholic patients and 44 controls. The pericerebral space (PICS) was calculated according to the formula (formula; see text) The PICS will increase in patients with brain atrophy since the ICV remains constant throughout life. The mean PICS value was 8.3% in controls, 11.3% in the alcoholic group, 14.7% in alcoholics with superimposed Wernicke's encephalopathy (thiamine deficiency) and 16.2% in those alcoholics with associated liver disease. Thus there was a statistically significant loss of brain tissue in chronic alcoholic patients which appeared to be more severe in those with associated nutritional vitamin deficiencies or alcoholic liver disease.
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| Title | Year | PMID |
|---|---|---|
| Event-Related Oscillations in Alcoholism Research: A Review. | 2012 | 24273686 |
| Contributions of studies on alcohol use disorders to understanding cerebellar function. | 2010 | 20809198 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Alcohol-Induced Changes in Brain Microstructure: Uncovering Novel Pathophysiological Mechanisms of AUD Using Translational DTI in Humans and Rodents. | Sommer WH et al. | β | 2025 | β |
| Long-Term Excessive Alcohol Consumption Enhances Myelination in the Mouse Nucleus Accumbens. | Liran M et al. | β | 2025 | β |
| Alcohol-induced damage to the fimbria/fornix reduces hippocampal-prefrontal cortex connection during early abstinence. | PΓ©rez-Cervera L et al. | β | 2023 | β |
| Sensitivity of Hypocretin System to Chronic Alcohol Exposure: A Human and Animal Study. | McGregor R et al. | β | 2023 | β |
| Sex differences in GABA<sub>A</sub> receptor subunit transcript expression are mediated by genotype in subjects with alcohol-related cirrhosis of the liver. | Ashton MK et al. | β | 2022 | β |
| Assessing the Role of Long Noncoding RNA in Nucleus Accumbens in Subjects With Alcohol Dependence. | Drake J et al. | β | 2020 | β |
| The Effect of Chronic Ethanol Exposure and Thiamine Deficiency on Myelin-related Genes in the Cortex and the Cerebellum. | Chatterton BJ et al. | β | 2020 | β |
| Assessing the role of long-noncoding RNA in nucleus accumbens in subjects with alcohol dependence | McMichael GO et al. | β | 2019 | β |
| Beyond genome-wide significance: integrative approaches to the interpretation and extension of GWAS findings for alcohol use disorder. | Salvatore JE et al. | β | 2019 | β |
| Predictors of Intraspinal Pressure and Optimal Cord Perfusion Pressure After Traumatic Spinal Cord Injury. | Hogg FRA et al. | β | 2019 | β |
| Alcohol-related diseases. | Weis S et al. | β | 2017 | β |
| The Differential Effects of Alcohol and Nicotine-Specific Nitrosamine Ketone on White Matter Ultrastructure. | Papp-Peka A et al. | β | 2017 | β |
| Negative and interactive effects of sex, aging, and alcohol abuse on gray matter morphometry. | Thayer RE et al. | β | 2016 | β |
| The effects of chronic smoking on the pathology of alcohol-related brain damage. | McCorkindale AN et al. | β | 2016 | β |
| Acetaldehyde, not ethanol, impairs myelin formation and viability in primary mouse oligodendrocytes. | Coutts DJ et al. | β | 2015 | β |
| Alcohol use across the lifespan: An analysis of adolescent and aged rodents and humans. | Novier A et al. | β | 2015 | β |
| Comparison of the deleterious effects of binge drinking-like alcohol exposure in adolescent and adult mice. | Lacaille H et al. | β | 2015 | β |
| Daily marijuana use is not associated with brain morphometric measures in adolescents or adults. | Weiland BJ et al. | β | 2015 | β |
| Differential Contributions of Alcohol and Nicotine-Derived Nitrosamine Ketone (NNK) to White Matter Pathology in the Adolescent Rat Brain. | Tong M et al. | β | 2015 | β |
| Dynamic responses of selective brain white matter fiber tracts to binge alcohol and recovery in the rat. | Pfefferbaum A et al. | β | 2015 | β |
| Neuropathology of alcoholism. | Sutherland GT et al. | β | 2014 | β |
| Widespread effects of alcohol on white matter microstructure. | Fortier CB et al. | β | 2014 | β |
| Deficits in cortical, diencephalic and midbrain gray matter in alcoholism measured by VBM: Effects of co-morbid substance abuse. | Grodin EN et al. | β | 2013 | β |
| The relationship between alcohol and cognitive functioning following traumatic brain injury. | Ponsford J et al. | β | 2013 | β |
| The role of Ξ±-synuclein in the pathophysiology of alcoholism. | Janeczek P et al. | β | 2013 | β |
| Event-Related Oscillations in Alcoholism Research: A Review. | Pandey AK et al. | β | 2012 | β |
| Clinical and pathological features of alcohol-related brain damage. | Zahr NM et al. | β | 2011 | β |
| Reduced cortical thickness in abstinent alcoholics and association with alcoholic behavior. | Fortier CB et al. | β | 2011 | β |
| Contributions of studies on alcohol use disorders to understanding cerebellar function. | Zahr NM et al. | β | 2010 | β |
| Exercise neuroprotection in a rat model of binge alcohol consumption. | Leasure JL et al. | β | 2010 | β |
| Recruitment of additional brain regions to accomplish simple motor tasks in chronic alcohol-dependent patients. | Parks MH et al. | β | 2010 | β |
| Impaired inhibition of proactive interference in abstinent individuals with alcoholism. | NoΓ«l X et al. | β | 2009 | β |
| Proteomics approach in the study of the pathophysiology of alcohol-related brain damage. | Matsumoto I | β | 2009 | β |
| The neuropathology of alcohol-related brain damage. | Harper C | β | 2009 | β |
| Neuropathology of alcohol-related cognitive alterations. | Harper C et al. | β | 2008 | β |
| Brain morphometry and cognitive performance in detoxified alcohol-dependents with preserved psychosocial functioning. | Chanraud S et al. | β | 2007 | β |
| CNS proteomes in alcohol and drug abuse and dependence. | Matsumoto I et al. | β | 2007 | β |
| Reversible cerebral atrophy: a case report and literature review. | Thirugnanasampanthan U et al. | β | 2006 | β |
| Changes in brain size in hepatic encephalopathy: a coregistered MRI study. | Patel N et al. | β | 2004 | β |
| Direct recording of the output of the motor cortex produced by transcranial magnetic stimulation in a patient with cerebral cortex atrophy. | Di Lazzaro V et al. | β | 2004 | β |
| The role of brain oscillations as functional correlates of cognitive systems: a study of frontal inhibitory control in alcoholism. | Kamarajan C et al. | β | 2004 | β |
| Biochemical and molecular studies using human autopsy brain tissue. | Hynd MR et al. | β | 2003 | β |
| Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre. | Harper C et al. | β | 2003 | β |
| Rapid computed tomography technique to measure ventricular volumes in the child with suspected ventriculoperitoneal shunt failure II. Clinical application. | Sze RW et al. | β | 2003 | β |
| Temporal discrimination learning in abstinent chronic alcoholics. | McGlinchey-Berroth R et al. | β | 2002 | β |
| Chemical pathology in brain white matter of recently detoxified alcoholics: a 1H magnetic resonance spectroscopy investigation of alcohol-associated frontal lobe injury. | Schweinsburg BC et al. | β | 2001 | β |
| Frontal lobe atrophy and central motor conduction time in chronic alcoholics. | Oishi M et al. | β | 1999 | β |
| Long-term voluntary ethanol consumption affects neither spatial nor passive avoidance learning, nor hippocampal acetylcholine release in alcohol-preferring rats. | Fadda F et al. | β | 1999 | β |
| Alcohol related dementia: proposed clinical criteria. | Oslin D et al. | β | 1998 | β |
| GABA(A) receptor alpha1, alpha4, and beta3 subunit mRNA and protein expression in the frontal cortex of human alcoholics. | Mitsuyama H et al. | β | 1998 | β |
| Atrophy of the corpus callosum in chronic alcoholism. | Estruch R et al. | β | 1997 | β |
| Brain impairment in well-nourished chronic alcoholics is related to ethanol intake. | NicolΓ‘s JM et al. | β | 1997 | β |
| Cerebral abnormalities in patients with cirrhosis detected by proton magnetic resonance spectroscopy and magnetic resonance imaging. | Geissler A et al. | β | 1997 | β |
| Chronic alcohol consumption does not cause hippocampal neuron loss in humans. | Harding AJ et al. | β | 1997 | β |
| Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. | Pfefferbaum A et al. | β | 1997 | β |
| Age-related changes in intracranial compartment volumes in normal adults assessed by magnetic resonance imaging. | Matsumae M et al. | β | 1996 | β |
| Chronic ethanol consumption in rats: correlation between memory performance and hippocampal acetylcholine release in vivo. | Melis F et al. | β | 1996 | β |
| Receptor binding sites and uptake activities mediating GABA neurotransmission in chronic alcoholics with Wernicke encephalopathy. | Dodd PR et al. | β | 1996 | β |
| Alcoholism and dementia. | Smith DM et al. | β | 1995 | β |
| Explorative and drinking behavior after prolonged access to alcohol and following chronic piracetam administration in mice. | Salimov R et al. | β | 1995 | β |
| Impaired delay eyeblink conditioning in amnesic Korsakoff's patients and recovered alcoholics. | McGlinchey-Berroth R et al. | β | 1995 | β |
| Medical manifestations of alcoholism in the elderly. | Smith JW | β | 1995 | β |
| Psychiatry and neuropathology: the maturing of a relationship. | Lishman WA | β | 1995 | β |
| Synapse-to-neuron ratio in the lateral geniculate nucleus of rats exposed chronically to ethanol. | KjellstrΓΆm C et al. | β | 1995 | β |
| The contribution of alcohol, thiamine deficiency and cirrhosis of the liver to cerebral cortical damage in alcoholics. | Kril JJ | β | 1995 | β |
| Alcoholic cognitive deterioration and nutritional deficiencies. | Molina JA et al. | β | 1994 | β |
| Alcoholic dementia. | Victor M | β | 1994 | β |
| Neurologic effects of alcoholism. | Diamond I et al. | β | 1994 | β |
| Brain autopsy in organic solvent syndrome. | Klinken L et al. | β | 1993 | β |
| Brain lesions in alcoholics. | Charness ME | β | 1993 | β |
| Event-related potential evidence of dysfunction in automatic processing in abstinent alcoholics. | Realmuto G et al. | β | 1993 | β |
| Alzheimer's disease and alcoholism: possible interactions. | Freund G et al. | β | 1992 | β |
| The effects of chronic alcohol consumption or thiamin deficiency on radial-arm maze performance in the rat. | Homewood J et al. | β | 1991 | β |
| Changes in the basal dendrites of cortical pyramidal cells from alcoholic patients--a quantitative Golgi study. | Harper C et al. | β | 1990 | β |
| Progression of neurological disease in thiamin-deficient rats is enhanced by ethanol. | Zimitat C et al. | β | 1990 | β |
| Ethanol and the nervous system. | Charness ME et al. | β | 1989 | β |
| Loss of muscarinic and benzodiazepine neuroreceptors from hippocampus of alcohol abusers. | Freund G et al. | β | 1989 | β |
| Loss of muscarinic cholinergic receptors from the temporal cortex of alcohol abusers. | Freund G et al. | β | 1989 | β |
| Neuroreceptor changes in the putamen of alcohol abusers. | Freund G et al. | β | 1989 | β |
| Brain CT changes in alcoholics: effects of age and alcohol consumption. | Pfefferbaum A et al. | β | 1988 | β |
| Brain damage and alcohol abuse: where do we go from here? | Harper CG | β | 1988 | β |
| Does a "moderate" alcohol intake damage the brain? | Harper C et al. | β | 1988 | β |
| Learning in young alcoholics. | Bowden SC | β | 1988 | β |
| Loss of cholinergic muscarinic receptors in the frontal cortex of alcohol abusers. | Freund G et al. | β | 1988 | β |
| A quantitative study of Australian aboriginal and Caucasian brains. | Klekamp J et al. | β | 1987 | β |
| Brain damage in alcoholism: current concepts. | Lishman WA et al. | β | 1987 | β |
| Effects of alcoholism on brain size. | Jacobson RR | β | 1987 | β |
| [Is the increase in brain volume of abstinent alcoholics a sequela of rehydration?]. | Claus D et al. | β | 1987 | β |
| The specific gravity of the brains of alcoholic and control patients: a pathological study. | Harper CG et al. | β | 1987 | β |
| Abstinence improves cerebral perfusion and brain volume in alcoholic neurotoxicity without Wernicke-Korsakoff syndrome. | Ishikawa Y et al. | β | 1986 | β |
| Alcoholic dementia: a hypothesis. | Lishman WA | β | 1986 | β |
| Brain atrophy and alcoholism. | Thomas PK | β | 1986 | β |
| Incidence of peripheral neuropathy and cerebellar ataxia in chronic alcoholics. | Scholz E et al. | β | 1986 | β |
| Recognition memory and psychophysiological responses to stimuli with neutral or emotional content: a study of Korsakoff patients and recently detoxified and longterm abstinent alcoholics. | Markowitsch HJ et al. | β | 1986 | β |
| Use of magnetic resonance imaging to measure intracranial cerebrospinal fluid volume. | Condon B et al. | β | 1986 | β |
| The neuropathology of amnesia. | Markowitsch HJ et al. | β | 1985 | β |