Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders.
paper
Cited
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- Authors
- Winstanley, Catharine A; Theobald, David E H; Dalley, Jeffrey W; Robbins, Trevor W
- Year
- 2005
- Journal
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- PMID
- 15688093
- DOI
- 10.1038/sj.npp.1300610
Forebrain serotonergic lesions attenuate the ability of d-amphetamine to decrease impulsivity in a delay-discounting paradigm, potentially through interactions between the serotonin (5-HT) and dopamine (DA) systems. Nucleus accumbens (NAC) lesions increase impulsivity, but the extent to which accumbal DA is involved in regulating impulsive choice is unknown. In the current study, the effects of intra-accumbal infusions of 6-hydroxydopamine (6-OHDA) on impulsive choice were evaluated, in combination with d-amphetamine and serotonergic drugs, in order to investigate the importance of 5-HT : DA interactions in the control of impulsive behavior. Following training on a delay-discounting task, animals received intra-NAC 6-OHDA or sham surgery. Postoperatively, subjects received systemic injections of d-amphetamine (0, 0.3, 1.0, 1.5 mg/kg) and the 5-HT(1A) receptor agonist 8-OH-DPAT (0, 0.1, 0.3, 1.0 mg/kg). Intra-NAC 6-OHDA, which reduced local DA and NA levels by 70-75%, had no effect on delay-discounting, but transiently potentiated the d-amphetamine-induced decrease in impulsive choice. 8-OH-DPAT (1.0 mg/kg) increased impulsivity in sham-operated controls, an effect which was blocked by the 5-HT(1A) receptor antagonist WAY 100635. However, 8-OH-DPAT had no effect on impulsivity in 6-OHDA NAC lesioned rats. 8-OH-DPAT (0.3 mg/kg), which did not itself alter task performance, blocked the effect of d-amphetamine in sham-operated controls, while WAY 100635 augmented the effect of amphetamine in all subjects. In an additional experiment, intracerebroventricular administration of the selective serotonergic toxin 5,7-dihydroxytryptamine, which decreased forebrain 5-HT levels by 85-90%, did not block 8-OH-DPAT's ability to increase impulsive choice. These data suggest a significant role for 5-HT : DA interactions within the NAC in the control of impulsivity, and in the mechanism by which amphetamine decreases impulsive choice.
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| Dopamine D2 receptors in nucleus accumbens cholinergic interneurons increase impulsive choice. | Cavallaro J et al. | β | 2023 | β |
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| Evolutionary and neuroendocrine foundations of human aggression. | Sarkar A et al. | β | 2023 | β |
| Not all discounts are created equal: Regional activity and brain networks in temporal and effort discounting. | Varma MM et al. | β | 2023 | β |
| A dynamical systems view of neuroethology: Uncovering stateful computation in natural behaviors. | Robson DN et al. | β | 2022 | β |
| A mutant allele of glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting. | Sanchez-Roige S et al. | β | 2022 | β |
| Anxiety predicts impulsive-compulsive behaviours in Parkinson's disease: Clinical relevance and theoretical implications. | Di Rosa E et al. | β | 2022 | β |
| Complexities and paradoxes in understanding the role of dopamine in incentive motivation and instrumental action: Exertion of effort vs. anhedonia. | Salamone JD et al. | β | 2022 | β |
| Digital Addiction and Sleep. | Dresp-Langley B et al. | β | 2022 | β |
| Increasing Central Serotonin with 5-hydroxytryptophan Disrupts the Inhibition of Social Gaze in Nonhuman Primates. | Weinberg-Wolf HB et al. | β | 2022 | β |
| The Effects of Drug Treatments for ADHD in Measures of Cognitive Performance. | Higgins GA et al. | β | 2022 | β |
| Between Temperament and Psychopathology: Examples from Neuropharmacological Challenge Tests in Healthy Humans. | Netter P | β | 2021 | β |
| Effects of a high-fat diet on impulsive choiceΒ in rats. | Garman TS et al. | β | 2021 | β |
| Imbalance between dopamine and serotonin caused by neonatal habenula lesion. | Lee YA et al. | β | 2021 | β |
| Kindling of the basolateral or central nucleus of the amygdala increases suboptimal choice in a rat gambling task and increases motor impulsivity in risk-preferring animals. | Tremblay M et al. | β | 2021 | β |
| Rational inattention and tonic dopamine. | Mikhael JG et al. | β | 2021 | β |
| Rejecting impulsivity as a psychological construct: A theoretical, empirical, and sociocultural argument. | Strickland JC et al. | β | 2021 | β |
| Effects of benztropine analogs on delay discounting in rats. | Soto PL et al. | β | 2020 | β |
| Involvement of noradrenergic and serotonergic systems in risk-based decisions between options of equivalent expected value in rats. | Cui RS et al. | β | 2020 | β |
| Risky decision-making predicts dopamine release dynamics in nucleus accumbens shell. | Freels TG et al. | β | 2020 | β |
| Serotonergic projections to the orbitofrontal and medial prefrontal cortices differentially modulate waiting for future rewards. | Miyazaki K et al. | β | 2020 | β |
| Serotonin in Animal Cognition and Behavior. | BacquΓ©-Cazenave J et al. | β | 2020 | β |
| The Neuropharmacology of Impulsive Behaviour, an Update. | Pattij T et al. | β | 2020 | β |
| Zebrafish models of impulsivity and impulse control disorders. | de Abreu MS et al. | β | 2020 | β |
| Association Between 5-HTTLPR Polymorphism and the Risk of Autism: A Meta-Analysis Based on Case-Control Studies. | Wang H et al. | β | 2019 | β |
| Dorsal raphe serotonin neurons inhibit operant responding for reward via inputs to the ventral tegmental area but not the nucleus accumbens: evidence from studies combining optogenetic stimulation and serotonin reuptake inhibition. | Browne CJ et al. | β | 2019 | β |
| Effects of d-amphetamine and MK-801 on impulsive choice: Modulation by schedule of reinforcement and delay length. | Yates JR et al. | β | 2019 | β |
| Prelimbic Cortical Neurons Track Preferred Reward Value and Reflect Impulsive Choice during Delay Discounting Behavior. | Sackett DA et al. | β | 2019 | β |
| Risky decision-making is associated with impulsive action and sensitivity to first-time nicotine exposure. | Gabriel DBK et al. | β | 2019 | β |
| Risky Decision-Making Predicts Dopamine Release Dynamics in Nucleus Accumbens Shell | Freels TG et al. | β | 2019 | β |
| The effect of 5-HT<sub>1A</sub> receptor antagonist on reward-based decision-making. | Akizawa F et al. | β | 2019 | β |
| The use of laser capture microdissection to identify specific pathways and mechanisms involved in impulsive choice in rats. | Meda S et al. | β | 2019 | β |
| 5-HT<sub>3</sub> antagonists decrease discounting rate without affecting sensitivity to reward magnitude in the delay discounting task in mice. | Mori M et al. | β | 2018 | β |
| Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder. | Kato TM et al. | β | 2018 | β |
| Dissecting drug effects in preclinical models of impulsive choice: emphasis on glutamatergic compounds. | Yates JR | β | 2018 | β |
| Pharmacotherapies for decreasing maladaptive choice in drug addiction: Targeting the behavior and the drug. | Perkins FN et al. | β | 2018 | β |
| The Psychopharmacology of Effort-Related Decision Making: Dopamine, Adenosine, and Insights into the Neurochemistry of Motivation. | Salamone JD et al. | β | 2018 | β |
| A framework for understanding and advancing intertemporal choice research using rodent models. | Fobbs WC et al. | β | 2017 | β |
| Differential effects of cannabinoid CB1 inverse agonists and antagonists on impulsivity in male Sprague Dawley rats: identification of a possibly clinically relevant vulnerability involving the serotonin 5HT<sub>1A</sub> receptor. | McLaughlin PJ et al. | β | 2017 | β |
| Dorsal Raphe Serotonergic Neurons Control Intertemporal Choice under Trade-off. | Xu S et al. | β | 2017 | β |
| Effects of intra-accumbal administration of dopamine and ionotropic glutamate receptor drugs on delay discounting performance in rats. | Yates JR et al. | β | 2017 | β |
| Effects of N-methyl-D-aspartate receptor ligands on sensitivity to reinforcer magnitude and delayed reinforcement in a delay-discounting procedure. | Yates JR et al. | β | 2017 | β |
| Effects of nucleus accumbens amphetamine administration on performance in a delay discounting task. | Orsini CA et al. | β | 2017 | β |
| Fatigue modulates dopamine availability and promotes flexible choice reversals during decision making. | Iodice P et al. | β | 2017 | β |
| Frontal Traumatic Brain Injury Increases Impulsive Decision Making in Rats: A Potential Role for the Inflammatory Cytokine Interleukin-12. | Vonder Haar C et al. | β | 2017 | β |
| Gambling disorder: an integrative review of animal and human studies. | Nautiyal KM et al. | β | 2017 | β |
| Increased temporal discounting after chronic stress in CHL1-deficient mice is reversed by 5-HT2C agonist Ro 60-0175. | Buhusi M et al. | β | 2017 | β |
| Investigation of impulsivity in binge-eating rats in a delay-discounting task and its prevention by the d-amphetamine prodrug, lisdexamfetamine. | Vickers SP et al. | β | 2017 | β |
| Mirtazapine and ketanserin alter preference for gambling-like schedules of reinforcement in rats. | Persons AL et al. | β | 2017 | β |
| Risk-taking, locomotor activity and dopamine levels in the nucleus accumbens and medial prefrontal cortex in male rats treated prenatally with alcohol. | MuΓ±oz-Villegas P et al. | β | 2017 | β |
| The 5-HT<sub>1A/1B</sub>-receptor agonist eltoprazine increases both catecholamine release in the prefrontal cortex and dopamine release in the nucleus accumbens and decreases motivation for reward and "waiting" impulsivity, but increases "stopping" impulsivity. | Korte SM et al. | β | 2017 | β |
| Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology. | Salamone JD et al. | β | 2016 | β |
| Age-Dependent D1-D2 Receptor Coactivation in the Lateral Orbitofrontal Cortex Potentiates NMDA Receptors and Facilitates Cognitive Flexibility. | Thompson JL et al. | β | 2016 | β |
| Anticonvulsant medications attenuate amphetamine-induced deficits in behavioral inhibition but not decision making under risk on a rat gambling task. | Tremblay M et al. | β | 2016 | β |
| Differential effects of the pharmacological stressor yohimbine on impulsive decision making and response inhibition. | Schippers MC et al. | β | 2016 | β |
| Effect of a human serotonin 5-HT<sub>2A</sub> receptor gene polymorphism on impulsivity: Dependence on cholesterol levels. | Tomson K et al. | β | 2016 | β |
| Effects of striatal lesions on components of choice: Reward discrimination, preference, and relative valuation. | Ricker JM et al. | β | 2016 | β |
| Enhanced attention and impulsive action following NMDA receptor GluN2B-selective antagonist pretreatment. | Higgins GA et al. | β | 2016 | β |
| Methamphetamine-, d-Amphetamine-, and p-Chloroamphetamine-Induced Neurotoxicity Differentially Effect Impulsive Responding on the Stop-Signal Task in Rats. | Furlong TM et al. | β | 2016 | β |
| Neural substrates underlying effort, time, and risk-based decision making in motivated behavior. | Bailey MR et al. | β | 2016 | β |
| Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making. | Zalocusky KA et al. | β | 2016 | β |
| Temperament and arousal systems: A new synthesis of differential psychology and functional neurochemistry. | Trofimova I et al. | β | 2016 | β |
| The developmental inter-relationships between activity, novelty preferences, and delay discounting in male and female rats. | Lukkes JL et al. | β | 2016 | β |
| The Neurobiological Mechanisms of Gamma-Hydroxybutyrate Dependence and Withdrawal and Their Clinical Relevance: A Review. | Kamal RM et al. | β | 2016 | β |
| The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences. | Salamone JD et al. | β | 2016 | β |
| Translatable and Back-Translatable Measurement of Impulsivity and Compulsivity: Convergent and Divergent Processes. | Voon V et al. | β | 2016 | β |
| A Computational Analysis of Aberrant Delay Discounting in Psychiatric Disorders. | Story GW et al. | β | 2015 | β |
| Deconstructing 5-HT6 receptor effects on striatal circuit function. | Eskenazi D et al. | β | 2015 | β |
| Hippocampal interplay with the nucleus accumbens is critical for decisions about time. | Abela AR et al. | β | 2015 | β |
| Identifying the Basal Ganglia network model markers for medication-induced impulsivity in Parkinson's disease patients. | Balasubramani PP et al. | β | 2015 | β |
| Impulsive delayed reward discounting as a genetically-influenced target for drug abuse prevention: a critical evaluation. | Gray JC et al. | β | 2015 | β |
| L-Dopa and Brain Serotonin System Dysfunction. | Stansley BJ et al. | β | 2015 | β |
| Mesolimbic dopamine dynamically tracks, and is causally linked to, discrete aspects of value-based decision making. | Saddoris MP et al. | β | 2015 | β |
| Parkinson's disease, the subthalamic nucleus, inhibition, and impulsivity. | Jahanshahi M et al. | β | 2015 | β |
| Role of basolateral amygdala dopamine D2 receptors in impulsive choice in acute cocaine-treated rats. | Li Y et al. | β | 2015 | β |
| Serotonin and inhibitory response control: focusing on the role of 5-HT(1A) receptors. | Pattij T et al. | β | 2015 | β |
| The interplay of birth weight, dopamine receptor D4 gene (DRD4), and early maternal care in the prediction of disorganized attachment at 36 months of age. | Wazana A et al. | β | 2015 | β |
| To Act or Not to Act: Endocannabinoid/Dopamine Interactions in Decision-Making. | Hernandez G et al. | β | 2015 | β |
| Trace amine-associated receptor 1: A promising target for the treatment of psychostimulant addiction. | Jing L et al. | β | 2015 | β |
| Tryptophan Depletion Promotes Habitual over Goal-Directed Control of Appetitive Responding in Humans. | Worbe Y et al. | β | 2015 | β |
| Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models. | Jupp B et al. | β | 2014 | β |
| Dopaminergic modulation of impulsive decision making in the rat insular cortex. | Pattij T et al. | β | 2014 | β |
| Effects of amphetamine and methylphenidate on delay discounting in rats: interactions with order of delay presentation. | Tanno T et al. | β | 2014 | β |
| Effects of amphetamine on delay discounting in rats depend upon the manner in which delay is varied. | Maguire DR et al. | β | 2014 | β |
| Gender-specific association of the SLC6A4 and DRD2 gene variants in bipolar disorder. | Wang TY et al. | β | 2014 | β |
| Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: on the path to an animal model of attention-deficit hyperactivity disorder. | Mergy MA et al. | β | 2014 | β |
| Interactions of timing and prediction error learning. | Kirkpatrick K | β | 2014 | β |
| Neurohistory in action: hoarding and the human past. | Smail DL | β | 2014 | β |
| Neurons in the nucleus accumbens promote selection bias for nearer objects. | Morrison SE et al. | β | 2014 | β |
| Recent Insights into the Neurobiology of Impulsivity. | Mitchell MR et al. | β | 2014 | β |
| Reducing substance use during adolescence: a translational framework for prevention. | Stanis JJ et al. | β | 2014 | β |
| Reward, interrupted: Inhibitory control and its relevance to addictions. | Jentsch JD et al. | β | 2014 | β |
| Role of medial prefrontal and orbitofrontal monoamine transporters and receptors in performance in an adjusting delay discounting procedure. | Yates JR et al. | β | 2014 | β |
| Selective serotonin reuptake inhibition modulates response inhibition in Parkinson's disease. | Ye Z et al. | β | 2014 | β |
| Transitions in the transcriptome of the serotonergic and dopaminergic systems in the human brain during adolescence. | Shoval G et al. | β | 2014 | β |
| Delay discounting task in pigs reveals response strategies related to dopamine metabolite. | Melotti L et al. | β | 2013 | β |
| Dopaminergic and GABA-ergic markers of impulsivity in rats: evidence for anatomical localisation in ventral striatum and prefrontal cortex. | Jupp B et al. | β | 2013 | β |
| Highly impulsive rats: modelling an endophenotype to determine the neurobiological, genetic and environmental mechanisms of addiction. | Jupp B et al. | β | 2013 | β |
| Impulsivity and substance-related attentional bias: a meta-analytic review. | Coskunpinar A et al. | β | 2013 | β |
| Integrating behavioral economics and behavioral genetics: delayed reward discounting as an endophenotype for addictive disorders. | MacKillop J | β | 2013 | β |
| Severe onychophagia and finger mutilation associated with obstructive sleep apnea. | Nino G et al. | β | 2013 | β |
| The combined effects of the 5- HTTLPR and HTR1A rs6295 polymorphisms modulate decision making in schizophrenia patients. | Gu H et al. | β | 2013 | β |
| Ventral striatal dopamine synthesis capacity predicts financial extravagance in Parkinson's disease. | Lawrence AD et al. | β | 2013 | β |
| A modified adjusting delay task to assess impulsive choice between isocaloric reinforcers in non-deprived male rats: effects of 5-HTβA/C and 5-HTβA receptor agonists. | Blasio A et al. | β | 2012 | β |
| Behavioural and physiological correlates of impulsivity in the domestic dog (Canis familiaris). | Wright HF et al. | β | 2012 | β |
| Chronic atomoxetine treatment during adolescence decreases impulsive choice, but not impulsive action, in adult rats and alters markers of synaptic plasticity in the orbitofrontal cortex. | Sun H et al. | β | 2012 | β |
| Dopamine, serotonin and impulsivity. | Dalley JW et al. | β | 2012 | β |
| Genetic variant of HTR2A associates with risk of impulse control and repetitive behaviors in Parkinson's disease. | Lee JY et al. | β | 2012 | β |
| High impulsivity in rats predicts amphetamine conditioned place preference. | Yates JR et al. | β | 2012 | β |
| Motivation and timing: clues for modeling the reward system. | Galtress T et al. | β | 2012 | β |
| Normative database of the serotonergic system in healthy subjects using multi-tracer PET. | Savli M et al. | β | 2012 | β |
| Serotonin and decision making processes. | Homberg JR | β | 2012 | β |
| Strain differences in delay discounting between Lewis and Fischer 344 rats at baseline and following acute and chronic administration of d-amphetamine. | Huskinson SL et al. | β | 2012 | β |
| The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond. | Salamone JD et al. | β | 2012 | β |
| The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients. | Jakubczyk A et al. | β | 2012 | β |
| The mysterious motivational functions of mesolimbic dopamine. | Salamone JD et al. | β | 2012 | β |
| The role of serotonin in the regulation of patience and impulsivity. | Miyazaki K et al. | β | 2012 | β |
| When too much is not enough: obsessive-compulsive disorder as a pathology of stopping, rather than starting. | Hinds AL et al. | β | 2012 | β |
| 5-HTβA receptor binding is increased after recovery from bulimia nervosa compared to control women and is associated with behavioral inhibition in both groups. | Bailer UF et al. | β | 2011 | β |
| Activation of the central serotonergic system in response to delayed but not omitted rewards. | Miyazaki KW et al. | β | 2011 | β |
| A functional variant of the serotonin transporter gene (SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings. | Sonuga-Barke EJ et al. | β | 2011 | β |
| Cannabinoid CB1 receptor activation mediates the opposing effects of amphetamine on impulsive action and impulsive choice. | Wiskerke J et al. | β | 2011 | β |
| Contributions of serotonin in addiction vulnerability. | Kirby LG et al. | β | 2011 | β |
| Contributions of the nucleus accumbens and its subregions to different aspects of risk-based decision making. | Stopper CM et al. | β | 2011 | β |
| Dissociable contributions by prefrontal D1 and D2 receptors to risk-based decision making. | St Onge JR et al. | β | 2011 | β |
| Effects of atomoxetine, desipramine, d-amphetamine and methylphenidate on impulsivity in juvenile rats, measured in a T-maze procedure. | Bizot JC et al. | β | 2011 | β |
| Effects of selective dopaminergic compounds on a delay-discounting task. | Koffarnus MN et al. | β | 2011 | β |
| From reinforcement learning models to psychiatric and neurological disorders. | Maia TV et al. | β | 2011 | β |
| Intracranial self-stimulation as a positive reinforcer to study impulsivity in a probability discounting paradigm. | Rokosik SL et al. | β | 2011 | β |
| Methylphenidate and fluphenazine, but not amphetamine, differentially affect impulsive choice in spontaneously hypertensive, Wistar-Kyoto and Sprague-Dawley rats. | Wooters TE et al. | β | 2011 | β |
| Nucleus accumbens neurons encode predicted and ongoing reward costs in rats. | Day JJ et al. | β | 2011 | β |
| Prefrontal cortex and drug abuse vulnerability: translation to prevention and treatment interventions. | Perry JL et al. | β | 2011 | β |
| Prenatal Cocaine Disrupts Serotonin Signaling-Dependent Behaviors: Implications for Sex Differences, Early Stress and Prenatal SSRI Exposure. | Williams SK et al. | β | 2011 | β |
| Serotonin (5-hydroxytryptamine) 5-HT(2A) receptor: association with inherent and cocaine-evoked behavioral disinhibition in rats. | Anastasio NC et al. | β | 2011 | β |
| Serotonin: imaging findings in eating disorders. | Bailer UF et al. | β | 2011 | β |
| The roles of dopamine and serotonin in decision making: evidence from pharmacological experiments in humans. | Rogers RD | β | 2011 | β |
| The utility of rat models of impulsivity in developing pharmacotherapies for impulse control disorders. | Winstanley CA | β | 2011 | β |
| ΞΌ-Opioid receptors in the nucleus accumbens shell region mediate the effects of amphetamine on inhibitory control but not impulsive choice. | Wiskerke J et al. | β | 2011 | β |
| Association between the dose of dopaminergic medication and the behavioral disturbances in Parkinson disease. | Lee JY et al. | β | 2010 | β |
| Associations between the serotonin-1A receptor C(-1019)G polymorphism and disordered eating symptoms in female adolescents. | Lim SW et al. | β | 2010 | β |
| Behavioural neuroscience: A gene for impulsivity. | Kelsoe JR | β | 2010 | β |
| Contributions of the orbitofrontal cortex to impulsive choice: interactions with basal levels of impulsivity, dopamine signalling, and reward-related cues. | Zeeb FD et al. | β | 2010 | β |
| Deep brain stimulation of the nucleus accumbens shell increases impulsive behavior and tissue levels of dopamine and serotonin. | Sesia T et al. | β | 2010 | β |
| Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism. | Nunes EJ et al. | β | 2010 | β |
| Dopamine receptor D1/D5 gene expression in the medial prefrontal cortex predicts impulsive choice in rats. | Loos M et al. | β | 2010 | β |
| Effects of acute and repeated nicotine administration on delay discounting in Lewis and Fischer 344 rats. | Anderson KG et al. | β | 2010 | β |
| Enhancement of spatial reversal learning by 5-HT2C receptor antagonism is neuroanatomically specific. | Boulougouris V et al. | β | 2010 | β |
| External incentives and internal states guide goal-directed behavior via the differential recruitment of the nucleus accumbens and the medial prefrontal cortex. | Moscarello JM et al. | β | 2010 | β |
| Good things come to those who wait: attenuated discounting of delayed rewards in aged Fischer 344 rats. | Simon NW et al. | β | 2010 | β |
| Impulsive choice and response in dopamine agonist-related impulse control behaviors. | Voon V et al. | β | 2010 | β |
| Interaction of SLC6A4 and DRD2 polymorphisms is associated with a history of delirium tremens. | Karpyak VM et al. | β | 2010 | β |
| Perinatal risk factors interacting with catechol O-methyltransferase and the serotonin transporter gene predict ASD symptoms in children with ADHD. | Nijmeijer JS et al. | β | 2010 | β |
| Prefrontal cortical contribution to risk-based decision making. | St Onge JR et al. | β | 2010 | β |
| Serotonergic modulation of response inhibition and re-engagement? Results of a study in healthy human volunteers. | Drueke B et al. | β | 2010 | β |
| Strengths and limitations of genetic models of ADHD. | Gainetdinov RR | β | 2010 | β |
| The effects of progesterone pretreatment on the response to oral d-amphetamine in Women. | Reed SC et al. | β | 2010 | β |
| The role of the nucleus accumbens core in impulsive choice, timing, and reward processing. | Galtress T et al. | β | 2010 | β |
| Understanding the construct of impulsivity and its relationship to alcohol use disorders. | Dick DM et al. | β | 2010 | β |
| Acute effects of morphine on distinct forms of impulsive behavior in rats. | Pattij T et al. | β | 2009 | β |
| Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease. | Lee JY et al. | β | 2009 | β |
| Bidirectional regulation of novelty-induced behavioral inhibition by the endocannabinoid system. | LafenΓͺtre P et al. | β | 2009 | β |
| Comparing the role of the anterior cingulate cortex and 6-hydroxydopamine nucleus accumbens lesions on operant effort-based decision making. | Walton ME et al. | β | 2009 | β |
| DeltaFosB induction in orbitofrontal cortex potentiates locomotor sensitization despite attenuating the cognitive dysfunction caused by cocaine. | Winstanley CA et al. | β | 2009 | β |
| Differential effects of d-amphetamine on impulsive choice in spontaneously hypertensive and Wistar-Kyoto rats. | Hand DJ et al. | β | 2009 | β |
| Dopaminergic modulation of risk-based decision making. | St Onge JR et al. | β | 2009 | β |
| Early life social isolation alters corticotropin-releasing factor responses in adult rats. | Lukkes JL et al. | β | 2009 | β |
| Gender differences in delay-discounting under mild food restriction. | Koot S et al. | β | 2009 | β |
| Methylphenidate to adolescent rats drives enduring changes of accumbal Htr7 expression: implications for impulsive behavior and neuronal morphology. | Leo D et al. | β | 2009 | β |
| Perturbations in different forms of cost/benefit decision making induced by repeated amphetamine exposure. | Floresco SB et al. | β | 2009 | β |
| Positron emission tomography measures of endogenous opioid neurotransmission and impulsiveness traits in humans. | Love TM et al. | β | 2009 | β |
| Restless legs syndrome induced by topiramate: two more cases. | Bermejo PE | β | 2009 | β |
| Cortico-limbic-striatal circuits subserving different forms of cost-benefit decision making. | Floresco SB et al. | β | 2008 | β |
| Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphΓ© differentially affect serotonin release in the nucleus accumbens. | Lukkes JL et al. | β | 2008 | β |
| Disparate cocaine-induced locomotion as a predictor of choice behavior in rats trained in a delay-discounting task. | Stanis JJ et al. | β | 2008 | β |
| Dopaminergic and glutamatergic regulation of effort- and delay-based decision making. | Floresco SB et al. | β | 2008 | β |
| Dopamine transporter mutant mice in experimental neuropharmacology. | Gainetdinov RR | β | 2008 | β |
| Effects of acute and repeated administration of caffeine on temporal discounting in rats. | Diller JW et al. | β | 2008 | β |
| Guidance of instrumental behavior under reversal conditions requires dopamine D1 and D2 receptor activation in the orbitofrontal cortex. | Calaminus C et al. | β | 2008 | β |
| Impulse control disorders in women with eating disorders. | FernΓ‘ndez-Aranda F et al. | β | 2008 | β |
| Neurobehavioral effects of head-only gamma-radiation exposure in rats. | Hienz RD et al. | β | 2008 | β |
| Neurobiology of anorexia and bulimia nervosa. | Kaye W | β | 2008 | β |
| Nucleus accumbens adenosine A2A receptors regulate exertion of effort by acting on the ventral striatopallidal pathway. | Mingote S et al. | β | 2008 | β |
| Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat. | Robinson ES et al. | β | 2008 | β |
| 5-HT1A-iCre, a new transgenic mouse line for genetic analyses of the serotonergic pathway. | Sahly I et al. | β | 2007 | β |
| An intact dopaminergic system is required for context-conditioned release of 5-HT in the nucleus accumbens of postweaning isolation-reared rats. | Fulford AJ et al. | β | 2007 | β |
| Calculating utility: preclinical evidence for cost-benefit analysis by mesolimbic dopamine. | Phillips PE et al. | β | 2007 | β |
| Delay discounting and impulsive choice in the rat. | Mar AC et al. | β | 2007 | β |
| Delay discounting in schizophrenia. | Heerey EA et al. | β | 2007 | β |
| Dimensional analysis of ADHD subtypes in rats. | Blondeau C et al. | β | 2007 | β |
| Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. | Salamone JD et al. | β | 2007 | β |
| Medication-related impulse control and repetitive behaviors in Parkinson's disease. | Voon V et al. | β | 2007 | β |
| Multidisciplinary perspectives on attention and the development of self-regulation. | Berger A et al. | β | 2007 | β |
| Role of the serotonin system in ADHD: treatment implications. | Oades RD | β | 2007 | β |
| The orbitofrontal cortex, impulsivity, and addiction: probing orbitofrontal dysfunction at the neural, neurochemical, and molecular level. | Winstanley CA | β | 2007 | β |
| Delay aversion: effects of 7-OH-DPAT, 5-HT1A/1B-receptor stimulation and D-cycloserine. | van den Bergh FS et al. | β | 2006 | β |
| Mesocortical dopamine modulation of executive functions: beyond working memory. | Floresco SB et al. | β | 2006 | β |
| Neural systems implicated in delayed and probabilistic reinforcement. | Cardinal RN | β | 2006 | β |
| The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. | Brookes K et al. | β | 2006 | β |
| Weighing up the benefits of work: behavioral and neural analyses of effort-related decision making. | Walton ME et al. | β | 2006 | β |
| Decision making: the virtue of patience in primates. | Long A et al. | β | 2005 | β |
| Effects of lesions of the nucleus accumbens core on choice between small certain rewards and large uncertain rewards in rats. | Cardinal RN et al. | β | 2005 | β |