Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABAA receptors in hippocampal neurons.
paper
Cited
Public
Unavailable
- Authors
- Wei, Weizheng; Faria, Leonardo Coutinho; Mody, Istvan
- Year
- 2004
- Journal
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- PMID
- 15385620
- DOI
- 10.1523/JNEUROSCI.2040-04.2004
- PMCID
- PMC6729680
In central neurons, a tonic conductance is activated by ambient levels of the inhibitory transmitter GABA. Here, we show that in dentate gyrus granule cells, where tonic inhibition is mediated by delta subunit-containing GABA(A) receptors, this conductance is augmented by low concentrations (30 mM) of ethanol. In contrast, the tonic inhibition mediated by alpha5 subunit-containing receptors of CA1 pyramidal cells is not affected. The effect of ethanol on tonic inhibition specifically reduces the excitability of the dentate gyrus and identifies the delta subunit-dependent tonic inhibition as a likely site of ethanol action in the brain.
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