Stem Cell-Based Human Blood-Brain Barrier Models for Drug Discovery and Delivery.
paper
Cited
Public
Unavailable
- Authors
- Aday, S; Cecchelli, R; Hallier-Vanuxeem, D; Dehouck, M P; Ferreira, L
- Year
- 2016
- Journal
- Trends in biotechnology
- PMID
- 26838094
- DOI
- 10.1016/j.tibtech.2016.01.001
The development of novel neuropharmaceuticals requires the evaluation of blood-brain barrier (BBB) permeability and toxicity. Recent studies have highlighted differences in the BBB among different species, with the most important differences involving the expression of P-glycoprotein (P-gp), multidrug resistance-associated proteins, transporters, and claudins. In addition, functional studies have shown that brain pharmacokinetics of P-glycoprotein substrates are different in humans and rodents. Therefore, human BBB models may be an important platform for initial drug screening before in vivo studies. This strategy might help to reduce costs in drug development and failures in clinical studies. We review the differences in the BBB among species, recent advances in the generation of human BBB models, and their applications in drug discovery and delivery.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A critical appraisal of drug transport across the blood-brain barrier: Evaluation using new-age microfluidic technique. | Marathe K et al. | β | 2026 | β |
| A fully iPS-cell-derived 3D model of the human blood-brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions. | GonzΓ‘lez-Gallego J et al. | β | 2026 | β |
| From insights to innovations: evaluating preclinical paradigms in demyelinating disease therapeutics. | Karbalaee M et al. | β | 2026 | β |
| A Microfluidic Blood Brain Barrier Model to Study the Influence of Glioblastoma Tumor Cells on BBB Function. | DePalma T et al. | β | 2025 | β |
| Blood-brain barrier repair: potential and challenges of stem cells and exosomes in stroke treatment. | Fu X et al. | β | 2025 | β |
| Engineering a streamlined virus-like particle for programmable tissue-specific gene delivery. | Han J et al. | β | 2025 | β |
| Glucosamine activates intestinal P-glycoprotein inhibiting drug absorption. | Wu Q et al. | β | 2025 | β |
| Life cycle exposure to differentially charged polystyrene nanoplastics leads to gender-specific particle accumulation and neurotoxicity in zebrafish (Danio rerio). | Teng M et al. | β | 2025 | β |
| Stem cell-derived brain-like endothelial cells to interrogate <i>Streptococcus pneumoniae</i> interaction with brain endothelium. | Mauser HD et al. | β | 2025 | β |
| Transcriptional Responses of In Vitro Blood-Brain Barrier Models to Shear Stress. | Foreman KL et al. | β | 2025 | β |
| Advances in modeling permeability and selectivity of the blood-brain barrier using microfluidics. | Sun J et al. | β | 2024 | β |
| Advances in physiological and clinical relevance of hiPSC-derived brain models for precision medicine pipelines. | Imani Farahani N et al. | β | 2024 | β |
| Bibliometric Analysis of the Role of Occludin in the Pathogenesis of Stroke. | Urasheva ZU et al. | β | 2024 | β |
| Blood-brain barrier dysfunction in aging is mediated by brain endothelial senescence. | Novo JP et al. | β | 2024 | β |
| Cerium oxide-modified Pd nanosheets encapsulated by red blood cell membranes for high-efficiency RONS scavenging in depression treatment. | Hu X et al. | β | 2024 | β |
| Co-Culture Models: Key Players in In Vitro Neurotoxicity, Neurodegeneration and BBB Modeling Studies. | Monteiro AR et al. | β | 2024 | β |
| Engineering extracellular vesicles to transiently permeabilize the blood-brain barrier. | Tomatis F et al. | β | 2024 | β |
| Human <i>in vitro</i> blood barrier models: architectures and applications. | Watson BE et al. | β | 2024 | β |
| Implementation of the neuro-glia-vascular unit through co-culture of adult neural stem cells and vascular cells and transcriptomic analysis of diverse AΞ² assembly types. | Heo C et al. | β | 2024 | β |
| Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids. | Dao L et al. | β | 2024 | β |
| Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine. | Summers RA et al. | β | 2024 | β |
| Oxytocin-induced birth causes sex-specific behavioral and brain connectivity changes in developing rat offspring. | Giri T et al. | β | 2024 | β |
| A Next-Generation 3D Tissue-Engineered Model of the Human Brain Microvasculature to Study the Blood-Brain Barrier. | Galpayage Dona KNU et al. | β | 2023 | β |
| A novel 4-cell in-vitro blood-brain barrier model and its characterization by confocal microscopy and TEER measurement. | Malik JR et al. | β | 2023 | β |
| Defined Differentiation of Human Pluripotent Stem Cells to Brain Microvascular Endothelial-Like Cells for Modeling the Blood-Brain Barrier. | Foreman KL et al. | β | 2023 | β |
| Engineering Neurovascular Unit and Blood-Brain Barrier for Ischemic Stroke Modeling. | Liu Z et al. | β | 2023 | β |
| Experimental Models of In Vitro Blood-Brain Barrier for CNS Drug Delivery: An Evolutionary Perspective. | Chaulagain B et al. | β | 2023 | β |
| From cells to organoids: The evolution of blood-brain barrier technology for modelling drug delivery in brain cancer. | Gonzales-Aloy E et al. | β | 2023 | β |
| High and low permeability of human pluripotent stem cell-derived blood-brain barrier models depend on epithelial or endothelial features. | Girard SD et al. | β | 2023 | β |
| Human iPS-derived blood-brain barrier model exhibiting enhanced barrier properties empowered by engineered basement membrane. | Choi JW et al. | β | 2023 | β |
| Locked Out: Phoenixin-14 Does Not Cross a Stem-Cell-Derived Blood-Brain Barrier Model. | Schalla MA et al. | β | 2023 | β |
| Mouse embryonic stem cell-derived blood-brain barrier model: applicability to studying antibody triggered receptor mediated transcytosis. | Jezierski A et al. | β | 2023 | β |
| TGF-Ξ² and SHH Regulate Pluripotent Stem Cell Differentiation into Brain Microvascular Endothelial Cells in Generating an In Vitro Blood-Brain Barrier Model. | Lee NG et al. | β | 2023 | β |
| The impact of Ξ±-synuclein aggregates on blood-brain barrier integrity in the presence of neurovascular unit cells. | Hourfar H et al. | β | 2023 | β |
| TIMP-1 Protects Tight Junctions of Brain Endothelial Cells From MMP-Mediated Degradation. | Ahmadighadykolaei H et al. | β | 2023 | β |
| Advances in BBB on Chip and Application for Studying Reversible Opening of Blood-Brain Barrier by Sonoporation. | Cai Y et al. | β | 2022 | β |
| Advances in vascularization and innervation of constructs for neural tissue engineering. | Newman Frisch A et al. | β | 2022 | β |
| A Microfluidic In Vitro Three-Dimensional Dynamic Model of the Blood-Brain Barrier to Study the Transmigration of Immune Cells. | Meena M et al. | β | 2022 | β |
| An <i>in vitro</i> Blood-brain Barrier Model to Study the Penetration of Nanoparticles. | Aday S et al. | β | 2022 | β |
| Astrocytes and human artificial blood-brain barrier models. | ZidariΔ T et al. | β | 2022 | β |
| ATP-binding cassette (ABC) drug transporters in the developing blood-brain barrier: role in fetal brain protection. | Eng ME et al. | β | 2022 | β |
| Current Status of <i>In vitro</i> Models of the Blood-brain Barrier. | Shah B et al. | β | 2022 | β |
| Electrospun Scaffolds as Cell Culture Substrates for the Cultivation of an In Vitro Blood-Brain Barrier Model Using Human Induced Pluripotent Stem Cells. | Rohde F et al. | β | 2022 | β |
| Experimental models for pharmacokinetic and pharmacodynamic studies of antifungals used in cryptococcosis treatment. | Wirth F et al. | β | 2022 | β |
| High and low permeability of human pluripotent stem cell-derived Blood Brain barrier models depend on epithelial or endothelial features | Girard SD et al. | β | 2022 | β |
| In vitro blood brain barrier models: An overview. | Jagtiani E et al. | β | 2022 | β |
| In Vitro Models of the Blood-Brain Barrier. | Raut S et al. | β | 2022 | β |
| Modeling Brain Tumors: A Perspective Overview of <i>in vivo</i> and Organoid Models. | Antonica F et al. | β | 2022 | β |
| Nanogels as Novel Nanocarrier Systems for Efficient Delivery of CNS Therapeutics. | Zhang Y et al. | β | 2022 | β |
| Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound. | Chen L et al. | β | 2022 | β |
| Organ-On-A-Chip Models of the Blood-Brain Barrier: Recent Advances and Future Prospects. | Kawakita S et al. | β | 2022 | β |
| Present and future of microglial pharmacology. | Ε imonΔiΔovΓ‘ E et al. | β | 2022 | β |
| Quantitative Targeted Absolute Proteomics for Better Characterization of an In Vitro Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells. | Dehouck MP et al. | β | 2022 | β |
| Strategies for developing complex multi-component in vitro tumor models: Highlights in glioblastoma. | DePalma TJ et al. | β | 2022 | β |
| Towards a gold standard functional readout to characterize In Vitro lung barriers. | Doryab A et al. | β | 2022 | β |
| Transport Studies Using Blood-Brain Barrier In Vitro Models: A Critical Review and Guidelines. | Santa-Maria AR et al. | β | 2022 | β |
| Ultrathin and handleable nanofibrous net as a novel biomimetic basement membrane material for endothelial barrier formation. | Wang Y et al. | β | 2022 | β |
| A Biomimetic Drug Delivery System by Integrating Grapefruit Extracellular Vesicles and Doxorubicin-Loaded Heparin-Based Nanoparticles for Glioma Therapy. | Niu W et al. | β | 2021 | β |
| Advances in Non-Animal Testing Approaches towards Accelerated Clinical Translation of Novel Nanotheranostic Therapeutics for Central Nervous System Disorders. | Lynch MJ et al. | β | 2021 | β |
| A Hybrid Nanofiber/Paper Cell Culture Platform for Building a 3D Blood-brain Barrier Model. | Huang K et al. | β | 2021 | β |
| Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using small-molecular-weight paracellular markers. | Kadry H et al. | β | 2021 | β |
| Defining the epitope of a blood-brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor. | Sheff J et al. | β | 2021 | β |
| Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers. | Turk OM et al. | β | 2021 | β |
| Drug Penetration into the Central Nervous System: Pharmacokinetic Concepts and In Vitro Model Systems. | Neumaier F et al. | β | 2021 | β |
| Dynamic 3D On-Chip BBB Model Design, Development, and Applications in Neurological Diseases. | Chen X et al. | β | 2021 | β |
| Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2Ξ±-Ve-Cadherin Pathway. | Rand D et al. | β | 2021 | β |
| Integrating in vitro disease models of the neurovascular unit into discovery and development of neurotherapeutics. | Ding Y et al. | β | 2021 | β |
| In Vitro Human Blood-Brain Barrier Model for Drug Permeability Testing. | Bayir E et al. | β | 2021 | β |
| Mechanisms of small cell lung cancer metastasis. | Ko J et al. | β | 2021 | β |
| Potential neurotoxicity of titanium implants: Prospective, in-vivo and in-vitro study. | Shelly S et al. | β | 2021 | β |
| Recent progress and new challenges in modeling of human pluripotent stem cell-derived blood-brain barrier. | Yan L et al. | β | 2021 | β |
| The Use of Tissue Engineering to Fabricate Perfusable 3D Brain Microvessels <i>in vitro</i>. | Galpayage Dona KNU et al. | β | 2021 | β |
| Advances in microphysiological blood-brain barrier (BBB) models towards drug delivery. | Lee CS et al. | β | 2020 | β |
| A face-to-face comparison of claudin-5 transduced human brain endothelial (hCMEC/D3) cells with porcine brain endothelial cells as blood-brain barrier models for drug transport studies. | Gericke B et al. | β | 2020 | β |
| Application of separation methods for in vitro prediction of blood-brain barrier permeability-The state of the art. | Ciura K et al. | β | 2020 | β |
| Considering the Experimental use of Temozolomide in Glioblastoma Research. | Herbener VJ et al. | β | 2020 | β |
| Contribution of brain pericytes in blood-brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells. | Heymans M et al. | β | 2020 | β |
| Establishment of an in Vitro Human Blood-Brain Barrier Model Derived from Induced Pluripotent Stem Cells and Comparison to a Porcine Cell-Based System. | Di Marco A et al. | β | 2020 | β |
| Human iPSC-Derived Blood-Brain Barrier Models: Valuable Tools for Preclinical Drug Discovery and Development? | Appelt-Menzel A et al. | β | 2020 | β |
| Human pluripotent stem cell-derived models and drug screening in CNS precision medicine. | Silva MC et al. | β | 2020 | β |
| LC-MS/MS-based in vitro and in vivo investigation of blood-brain barrier integrity by simultaneous quantitation of mannitol and sucrose. | Noorani B et al. | β | 2020 | β |
| <i>In vitro</i> and computational modelling of drug delivery across the outer blood-retinal barrier. | Davies AE et al. | β | 2020 | β |
| Materials for blood brain barrier modeling <i>in vitro</i>. | Ferro MP et al. | β | 2020 | β |
| Microengineered human blood-brain barrier platform for understanding nanoparticle transport mechanisms. | Ahn SI et al. | β | 2020 | β |
| Modeling Nanocarrier Transport across a 3D In Vitro Human Blood-Brain-Barrier Microvasculature. | Lee SWL et al. | β | 2020 | β |
| Recent advances in human iPSC-derived models of the blood-brain barrier. | Workman MJ et al. | β | 2020 | β |
| Transcriptomic comparison of human and mouse brain microvessels. | Song HW et al. | β | 2020 | β |
| Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier. | ClΓ© M et al. | β | 2020 | β |
| Advances in Microfluidic Blood-Brain Barrier (BBB) Models. | Oddo A et al. | β | 2019 | β |
| An in vitro model mimics the contact of biomaterials to blood components and the reaction of surrounding soft tissue. | Jannasch M et al. | β | 2019 | β |
| Application of an in Vitro Blood-Brain Barrier Model in the Selection of Experimental Drug Candidates for the Treatment of Huntington's Disease. | Di Marco A et al. | β | 2019 | β |
| Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms. | Oksanen M et al. | β | 2019 | β |
| Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells. | PraΓ§a C et al. | β | 2019 | β |
| Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties. | Dos Santos Rodrigues B et al. | β | 2019 | β |
| Finding Needles in a Haystack: Determining Key Molecular Descriptors Associated with the Blood-brain Barrier Entry of Chemical Compounds Using Machine Learning. | Majumdar S et al. | β | 2019 | β |
| In-vitro blood-brain barrier models for drug screening and permeation studies: an overview. | Bagchi S et al. | β | 2019 | β |
| Nanomaterial-based blood-brain-barrier (BBB) crossing strategies. | Xie J et al. | β | 2019 | β |
| Prediction of Drug Permeability Using <i>In Vitro</i> Blood-Brain Barrier Models with Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells. | Ohshima M et al. | β | 2019 | β |
| The use of bacterial cellulose as a basement membrane improves the plausibility of the static in vitro blood-brain barrier model. | Bayir E et al. | β | 2019 | β |
| Using miniature brain implants in rodents for novel drug discovery. | Waldau B | β | 2019 | β |
| Controlling Differentiation of Stem Cells for Developing Personalized Organ-on-Chip Platforms. | Geraili A et al. | β | 2018 | β |
| Emerging Technologies for Delivery of Biotherapeutics and Gene Therapy Across the Blood-Brain Barrier. | Stanimirovic DB et al. | β | 2018 | β |
| Establishment of a Human iPSC- and Nanofiber-Based Microphysiological Blood-Brain Barrier System. | Qi D et al. | β | 2018 | β |
| Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells? | Prytkova I et al. | β | 2018 | β |
| HAI Peptide and Backbone Analogs-Validation and Enhancement of Biostability and Bioactivity of BBB Shuttles. | Arranz-Gibert P et al. | β | 2018 | β |
| In-vitro blood-brain barrier modeling: A review of modern and fast-advancing technologies. | Sivandzade F et al. | β | 2018 | β |
| In vitro models and systems for evaluating the dynamics of drug delivery to the healthy and diseased brain. | Modarres HP et al. | β | 2018 | β |
| Modeling the blood-brain barrier: Beyond the endothelial cells. | Gastfriend BD et al. | β | 2018 | β |
| Neurovascular dysfunction in dementia - human cellular models and molecular mechanisms. | Parkes I et al. | β | 2018 | β |
| Pericytes Derived from Human Pluripotent Stem Cells. | Jamieson J et al. | β | 2018 | β |
| Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach. | Yamamoto Y et al. | β | 2018 | β |
| Stem cells technology: a powerful tool behind new brain treatments. | Duru LN et al. | β | 2018 | β |
| Triphenyl Phosphate (TPHP)-Induced Neurotoxicity in Adult Male Chinese Rare Minnows ( Gobiocypris rarus). | Hong X et al. | β | 2018 | β |
| Engineering the human blood-brain barrier in vitro. | Jamieson JJ et al. | β | 2017 | β |
| Induced pluripotent stem cell technology: a decade of progress. | Shi Y et al. | β | 2017 | β |
| InΒ Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling. | Yamamizu K et al. | β | 2017 | β |
| Isogenic blood-brain barrier models based on patient-derived stem cells display inter-individual differences in cell maturation and functionality. | Patel R et al. | β | 2017 | β |
| New experimental models of the blood-brain barrier for CNS drug discovery. | Kaisar MA et al. | β | 2017 | β |
| In vitro blood-brain barrier models for drug research: state-of-the-art and new perspectives on reconstituting these models on artificial basement membrane platforms. | Banerjee J et al. | β | 2016 | β |
| Light-Patterned RNA Interference of 3D-Cultured Human Embryonic Stem Cells. | Huang X et al. | β | 2016 | β |
| Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases. | Saraiva C et al. | β | 2016 | β |
| Translational Prospects and Challenges in Human Induced Pluripotent Stem Cell Research in Drug Discovery. | Hosoya M et al. | β | 2016 | β |