Genetic architecture for human aggression: A study of gene-phenotype relationship in OMIM.
- Authors
- Zhang-James, Yanli; Faraone, Stephen V
- Year
- 2016
- Journal
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- PMID
- 26288127
- DOI
- 10.1002/ajmg.b.32363
Genetic studies of human aggression have mainly focused on known candidate genes and pathways regulating serotonin and dopamine signaling and hormonal functions. These studies have taught us much about the genetics of human aggression, but no genetic locus has yet achieved genome-significance. We here present a review based on a paradoxical hypothesis that studies of rare, functional genetic variations can lead to a better understanding of the molecular mechanisms underlying complex multifactorial disorders such as aggression. We examined all aggression phenotypes catalogued in Online Mendelian Inheritance in Man (OMIM), an Online Catalog of Human Genes and Genetic Disorders. We identified 95 human disorders that have documented aggressive symptoms in at least one individual with a well-defined genetic variant. Altogether, we retrieved 86 causal genes. Although most of these genes had not been implicated in human aggression by previous studies, the most significantly enriched canonical pathways had been previously implicated in aggression (e.g., serotonin and dopamine signaling). Our findings provide strong evidence to support the causal role of these pathways in the pathogenesis of aggression. In addition, the novel genes and pathways we identified suggest additional mechanisms underlying the origins of human aggression. Genome-wide association studies with very large samples will be needed to determine if common variants in these genes are risk factors for aggression. © 2015 Wiley Periodicals, Inc.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genetic association study of childhood aggression across raters, instruments, and age. | 2021 | 34330890 |
| Genetic influences on conduct disorder. | 2018 | 27350097 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A systematic review of the etiology and neurobiology of intermittent explosive disorder. | Paliakkara J et al. | — | 2025 | → |
| Severity of erectile dysfunction and premature ejaculation positively correlate with aggression levels in men: insights from a large population-representative study. | Przydacz M et al. | — | 2025 | → |
| Behavioral neuroscience in zebrafish: unravelling the complexity of brain-behavior relationships. | Firdous SM et al. | — | 2024 | → |
| Genetics and epigenetics of human aggression. | Odintsova VV et al. | — | 2023 | → |
| Association of serotonin system-related genes with homicidal behavior and criminal aggression in a prison population of Pakistani Origin. | Qadeer MI et al. | — | 2021 | → |
| Exploring the Contribution to ADHD of Genes Involved in Mendelian Disorders Presenting with Hyperactivity and/or Inattention. | Fernàndez-Castillo N et al. | — | 2021 | → |
| Genetic association study of childhood aggression across raters, instruments, and age. | Ip HF et al. | — | 2021 | → |
| Identification of key pathways and genes responsible for aggressive behavior. | Uddin N et al. | — | 2020 | → |
| Monoamine and neuroendocrine gene-sets associate with frustration-based aggression in a gender-specific manner. | van Donkelaar MMJ et al. | — | 2020 | → |
| The biology of aggressive behavior in bipolar disorder: A systematic review. | Fico G et al. | — | 2020 | → |
| An integrated analysis of genes and functional pathways for aggression in human and rodent models. | Zhang-James Y et al. | — | 2019 | → |
| Conduct disorder. | Fairchild G et al. | — | 2019 | → |
| Emerging roles of Fgf14 in behavioral control. | Hoxha E et al. | — | 2019 | → |
| Genomics of human aggression: current state of genome-wide studies and an automated systematic review tool. | Odintsova VV et al. | — | 2019 | → |
| Rare copy number variation in extremely impulsively violent males. | Vevera J et al. | — | 2019 | → |
| Understanding zebrafish aggressive behavior. | Zabegalov KN et al. | — | 2019 | → |
| Differential Roles of the Two Raphe Nuclei in Amiable Social Behavior and Aggression - An Optogenetic Study. | Balázsfi D et al. | — | 2018 | → |
| Genetic influences on conduct disorder. | Salvatore JE et al. | — | 2018 | → |
| Polymorphism of serotonin transporter gene in male subjects with antisocial behavior and MMA fighters. | Cherepkova EV et al. | — | 2018 | → |
| Oppositional defiant disorder: current insight. | Ghosh A et al. | — | 2017 | → |
| Targeting aggression in severe mental illness: The predictive role of genetic, epigenetic, and metabolomic markers. | Manchia M et al. | — | 2017 | → |
| Reciprocal moderation by <i>Toxoplasma gondii</i> seropositivity and blood phenylalanine - tyrosine ratio of their associations with trait aggression. | Mathai AJ et al. | — | 2016 | → |
| The genetics of aggression: Where are we now? | Asherson P et al. | — | 2016 | → |