Finding function in novel targets: C. elegans as a model organism.
paper
Cited
Public
Unavailable
- Authors
- Kaletta, Titus; Hengartner, Michael O
- Year
- 2006
- Journal
- Nature reviews. Drug discovery
- PMID
- 16672925
- DOI
- 10.1038/nrd2031
Despite its apparent simplicity, the nematode worm Caenorhabditis elegans has developed into an important model for biomedical research, particularly in the functional characterization of novel drug targets that have been identified using genomics technologies. The cellular complexity and the conservation of disease pathways between C. elegans and higher organisms, together with the simplicity and cost-effectiveness of cultivation, make for an effective in vivo model that is amenable to whole-organism high-throughput compound screens and large-scale target validation. This review describes how C. elegans models can be used to advance our understanding of the molecular mechanisms of drug action and disease pathogenesis.
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| 1-Mesityl-3-(3-Sulfonatopropyl) Imidazolium Protects Against Oxidative Stress and Delays Proteotoxicity in <i>C. elegans</i>. | Andersen N et al. | โ | 2022 | โ |
| Acute, Sublethal, and Developmental Toxicity of Kratom (<i>Mitragyna speciosa</i> Korth.) Leaf Preparations on <i>Caenorhabditis elegans</i> as an Invertebrate Model for Human Exposure. | Hughes S et al. | โ | 2022 | โ |
| A Decade of CRISPR-Cas Gnome Editing in <i>C. elegans</i>. | Kim HM et al. | โ | 2022 | โ |
| AdoR-1 (Adenosine Receptor) Contributes to Protection against Paraquat-Induced Oxidative Stress in <i>Caenorhabditis elegans</i>. | Ling C et al. | โ | 2022 | โ |
| A liquid-culture-based screening approach to study compounds affecting inflammatory processes in <i>Caenorhabditis elegans</i>. | Nguyen VTT et al. | โ | 2022 | โ |
| A new use for old drugs: identifying compounds with an anti-obesity effect using a high through-put semi-automated <i>Caenorhabditis elegans</i> screening platform. | Haerkens F et al. | โ | 2022 | โ |
| Anti-Larval and Anti-Algal Natural Products from Marine Microorganisms as Sources of Anti-Biofilm Agents. | Wang KL et al. | โ | 2022 | โ |
| Apigenin glycosides from green pepper enhance longevity and stress resistance in Caenorhabditis elegans. | Elkhedir AE et al. | โ | 2022 | โ |
| Assessment of the effects of organic vs. inorganic arsenic and mercury in <i>Caenorhabditis elegans</i>. | Camacho J et al. | โ | 2022 | โ |
| Caenorhabditis elegans provides an efficient drug screening platform for GNAO1-related disorders and highlights the potential role of caffeine in controlling dyskinesia. | Di Rocco M et al. | โ | 2022 | โ |
| cep-1 mediated the mitohormesis effect of Shengmai formula in regulating Caenorhabditis elegans lifespan. | Zhi D et al. | โ | 2022 | โ |
| Characterization of Nematicidal Activity and Nematode-Toxic Metabolites of a Soilborne <i>Brevundimonas bullata</i> Isolate. | Li J et al. | โ | 2022 | โ |
| Confounds of using the unc-58 selection marker highlights the importance of genotyping co-CRISPR genes. | Rawsthorne-Manning H et al. | โ | 2022 | โ |
| Cross-species metabolomic analysis of tau- and DDT-related toxicity. | Kalia V et al. | โ | 2022 | โ |
| Curcumin and Quercetin-Loaded Lipid Nanocarriers: Development of Omega-3 Mucoadhesive Nanoemulsions for Intranasal Administration. | Vaz GR et al. | โ | 2022 | โ |
| CYP35 family in Caenorhabditis elegans biological processes: fatty acid synthesis, xenobiotic metabolism, and stress responses. | Lim SYM et al. | โ | 2022 | โ |
| Cytochromes P450 of <i>Caenorhabditis elegans</i>: Implication in Biological Functions and Metabolism of Xenobiotics. | Larigot L et al. | โ | 2022 | โ |
| Demystifying the O-GlcNAc Code: A Systems View. | Ma J et al. | โ | 2022 | โ |
| Dissecting lipid droplet biology with coherent Raman scattering microscopy. | Chen T et al. | โ | 2022 | โ |
| Drosophila: A Model to Study the Pathogenesis of Parkinson's Disease. | Rahul et al. | โ | 2022 | โ |
| Drug discovery from natural products - Old problems and novel solutions for the treatment of neurodegenerative diseases. | Maitra U et al. | โ | 2022 | โ |
| Epigenetic effects of graphene oxide and its derivatives: A mini-review. | Ghazimoradi MM et al. | โ | 2022 | โ |
| Evidence for Complex Interplay between Quorum Sensing and Antibiotic Resistance in Pseudomonas aeruginosa. | Sikdar R et al. | โ | 2022 | โ |
| Exposome, Molecular Pathways and One Health: The Invertebrate <i>Caenorhabditis elegans</i>. | von Mikecz A | โ | 2022 | โ |
| Gain of Function of Malate Dehydrogenase 2 and Familial Hyperglycemia. | Jungtrakoon Thamtarana P et al. | โ | 2022 | โ |
| Heparan sulfate proteoglycans mediate prion-like ฮฑ-synuclein toxicity in Parkinson's in vivo models. | Chen M et al. | โ | 2022 | โ |
| Host Genetic Determinants of the Microbiome Across Animals: From <i>Caenorhabditis elegans</i> to Cattle. | Ryu EP et al. | โ | 2022 | โ |
| How to keep up with the analysis of classic and emerging neurotoxins: Age-resolved fitness tests in the animal model <i>Caenorhabditis elegans</i> - a step-by-step protocol. | Hering I et al. | โ | 2022 | โ |
| <i>Caenorhabditis elegans</i> as an <i>in vivo</i> model for food bioactives: A review. | Mudd N et al. | โ | 2022 | โ |
| Inferring a spatial code of cell-cell interactions across a whole animal body. | Armingol E et al. | โ | 2022 | โ |
| Insights into cisplatin-induced neurotoxicity and mitochondrial dysfunction in Caenorhabditis elegans. | Martรญnez-Fernรกndez C et al. | โ | 2022 | โ |
| In vivo toxicity assessment of eugenol and vanillin-functionalised silica particles using Caenorhabditis elegans. | Fuentes C et al. | โ | 2022 | โ |
| Iron overload and neurodegenerative diseases: What can we learn from <i>Caenorhabditis elegans</i>? | Martins AC et al. | โ | 2022 | โ |
| LC-MS/MS Insight into Vitamin C Restoration to Metabolic Disorder Evoked by Amyloid ฮฒ in <i>Caenorhabditis elegans</i> CL2006. | Zhang S et al. | โ | 2022 | โ |
| Lysinibacillus sphaericus mediates stress responses and attenuates arsenic toxicity in Caenorhabditis elegans. | Mangu JCK et al. | โ | 2022 | โ |
| Manganese-Induced Toxicity in <i>C. elegans</i>: What Can We Learn from the Transcriptome? | Nicolai MM et al. | โ | 2022 | โ |
| Mechanism of Longevity Extension of <i>Caenorhabditis elegans</i> Induced by <i>Schizophyllum commune</i> Fermented Supernatant With Added Radix Puerariae. | Deng Y et al. | โ | 2022 | โ |
| Meta-lens light-sheet fluorescence microscopy for <i>in vivo</i> imaging. | Luo Y et al. | โ | 2022 | โ |
| Mitochonic Acid 5 Improves Duchenne Muscular Dystrophy and Parkinson's Disease Model of <i>Caenorhabditis elegans</i>. | Wu X et al. | โ | 2022 | โ |
| Natural Bioactive Products and Alzheimer's Disease Pathology: Lessons from <i>Caenorhabditis elegans</i> Transgenic Models. | Navarro-Hortal MD et al. | โ | 2022 | โ |
| Nematode surface functionalization with hydrogel sheaths tailored <i>in situ</i>. | Mubarok W et al. | โ | 2022 | โ |
| Oxidative stress suppression in <i>C</i>. <i>elegans</i> by peptides from dogfish skin <i>via</i> regulation of transcription factors DAF-16 and HSF-1. | Ma X et al. | โ | 2022 | โ |
| Pollutants corrupt resilience pathways of aging in the nematode <i>C</i>. <i>elegans</i>. | Scharf A et al. | โ | 2022 | โ |
| Pseudo toxicity abatement effect of norfloxacin and copper combined exposure on Caenorhabditis elegans. | Liu L et al. | โ | 2022 | โ |
| Rapid assessment of the temporal function and phenotypic reversibility of neurodevelopmental disorder risk genes in Caenorhabditis elegans. | Kepler LD et al. | โ | 2022 | โ |
| Reciprocating intestinal flows enhance glucose uptake in C. elegans. | Suzuki Y et al. | โ | 2022 | โ |
| Review of the toxicity and potential molecular mechanisms of parental or successive exposure to environmental pollutants in the model organism Caenorhabditis elegans. | Li H et al. | โ | 2022 | โ |
| Salmonella Typhimurium infection causes defects and fastening of Caenorhabditis elegans developmental stages. | Mishra N et al. | โ | 2022 | โ |
| Tetrachlorobisphenol A mediates reproductive toxicity in Caenorhabditis elegans via DNA damage-induced apoptosis. | Yu Y et al. | โ | 2022 | โ |
| The Endogenous Metabolite Glycerophosphocholine Promotes Longevity and Fitness in <i>Caenorhabditis elegans</i>. | Liu JY et al. | โ | 2022 | โ |
| The evolving role of the Caenorhabditis elegans model as a tool to advance studies in nutrition and health. | Chakravarty B | โ | 2022 | โ |
| The Impact of Background-Level Carboxylated Single-Walled Carbon Nanotubes (SWCNTs-COOH) on Induced Toxicity in <i>Caenorhabditis elegans</i> and Human Cells. | Lu JH et al. | โ | 2022 | โ |
| The Role of Alternative Toxicological Trials in Drug Discovery Programs. The Case of <i>Caenorhabditis elegans</i> and Other Methods. | Gรถethel G et al. | โ | 2022 | โ |
| Three-Dimensional Arenas for the Assessment of <i>Caenorhabditis elegans</i> Behavior. | Cardoza S et al. | โ | 2022 | โ |
| Translational relevance of forward genetic screens in animal models for the study of psychiatric disease. | Sheardown E et al. | โ | 2022 | โ |
| Unconventional Myosins from <i>Caenorhabditis elegans</i> as a Probe to Study Human Orthologues. | Johnson CA et al. | โ | 2022 | โ |
| Using a <i>Caenorhabditis elegans</i> Parkinson's Disease Model to Assess Disease Progression and Therapy Efficiency. | Hughes S et al. | โ | 2022 | โ |
| ฮฒ-carotene genetically-enriched lyophilized orange juice increases antioxidant capacity and reduces ฮฒ-amyloid proteotoxicity and fat accumulation in <i>Caenorhabditis elegans</i>. | Raquel Ferreira Paulo I et al. | โ | 2022 | โ |
| Acute Toxicity and Transgenerational Effects of Perfluorobutane Sulfonate on Caenorhabditis elegans. | Chowdhury MI et al. | โ | 2021 | โ |
| An economical and highly adaptable optogenetics system for individual and population-level manipulation of Caenorhabditis elegans. | Koopman M et al. | โ | 2021 | โ |
| An In Vivo Microfluidic Study of Bacterial Load Dynamics and Absorption in the <i>C. elegans</i> Intestine. | Viri V et al. | โ | 2021 | โ |
| Antiaging Effects of <i>Vicatia thibetica de Boiss</i> Root Extract on <i>Caenorhabditis elegans</i> and Doxorubicin-Induced Premature Aging in Adult Mice. | Liu W et al. | โ | 2021 | โ |
| Bacterial Quality, Prevalence of Pathogens, and Molecular Characterization of Biofilm-Producing <i>Staphylococcus aureus</i> from Korean Dairy Farm Environments. | Ryu S et al. | โ | 2021 | โ |
| Benzo[a]pyrene and Caenorhabditis elegans: defining the genotoxic potential in an organism lacking the classical CYP1A1 pathway. | Abbass M et al. | โ | 2021 | โ |
| Beyond Proteostasis: Lipid Metabolism as a New Player in ER Homeostasis. | Xu J et al. | โ | 2021 | โ |
| Bioassays to screen the toxicity in drinking water samples collected in Brazilian rural area. | Brucker N et al. | โ | 2021 | โ |
| C. elegans: A biosensor for host-microbe interactions. | Backes C et al. | โ | 2021 | โ |
| Gentamicin encapsulated within a biopolymer for the treatment of <i>Staphylococcus aureus</i> and <i>Escherichia coli</i> infected skin ulcers. | Gemeinder JLP et al. | โ | 2021 | โ |
| Ginkgo seed extract promotes longevity and stress resistance of <i>Caenorhabditis elegans</i>. | Shen N et al. | โ | 2021 | โ |
| <i>Caenorhabditis elegans</i> to Model the Capacity of Ascorbic Acid to Reduce Acute Nitrite Toxicity under Different Feed Conditions: Multivariate Analytics on Behavioral Imaging. | Verdu S et al. | โ | 2021 | โ |
| Identification of simple arylfluorosulfates as potent agents against resistant bacteria. | Zhang J et al. | โ | 2021 | โ |
| <i>In Silico</i> Investigation of Conserved miRNAs and Their Targets From the Expressed Sequence Tags in <i>Neospora Caninum</i> Genome. | Das M et al. | โ | 2021 | โ |
| <i>In vivo</i> imaging of fluorescent single-walled carbon nanotubes within <i>C.ย elegans</i> nematodes in the near-infrared window. | Hendler-Neumark A et al. | โ | 2021 | โ |
| <i>Inย vivo</i> testing of mucus-permeating nanoparticles for oral insulin delivery using <i>Caenorhabditis elegans</i> as a model under hyperglycemic conditions. | Martรญnez-Lรณpez AL et al. | โ | 2021 | โ |
| Impact of Tuning the Surface Charge Distribution on Colloidal Iron Oxide Nanoparticle Toxicity Investigated in <i>Caenorhabditis elegans</i>. | Amigoni L et al. | โ | 2021 | โ |
| Investigation of cardiolipin oxidation products as a new endpoint for oxidative stress in C. elegans by means of online two-dimensional liquid chromatography and high-resolution mass spectrometry. | Helmer PO et al. | โ | 2021 | โ |
| Male reproductive toxicity involved in spermatogenesis induced by perfluorooctane sulfonate and perfluorooctanoic acid in Caenorhabditis elegans. | Yin J et al. | โ | 2021 | โ |
| Modelling epilepsy in the mouse: challenges and solutions. | Marshall GF et al. | โ | 2021 | โ |
| Molecular Basis of Neuronal Autophagy in Ageing: Insights from <i>Caenorhabditis elegans</i>. | Konstantinidis G et al. | โ | 2021 | โ |
| Neuroligin dependence of social behaviour in Caenorhabditis elegans provides a model to investigate an autism-associated gene. | Rawsthorne H et al. | โ | 2021 | โ |
| Novel Extraction Method for Combined Lipid and Metal Speciation From <i>Caenorhabditis elegans</i> With Focus on Iron Redox Status and Lipid Profiling. | Blume B et al. | โ | 2021 | โ |
| Novel Features for Binary Time Series Based on Branch Length Similarity Entropy. | Lee SH et al. | โ | 2021 | โ |
| Novel structure in the nuclei of honey bee brain neurons revealed by immunostaining. | Hurd PJ et al. | โ | 2021 | โ |
| Overexpression of FKH-2/FOXG1 is neuroprotective in a C. elegans model of Machado-Joseph disease. | Fardghassemi Y et al. | โ | 2021 | โ |
| Parkinson's disease and microRNAs - Lessons from model organisms and human studies. | Evans B et al. | โ | 2021 | โ |
| Quo Vadis <i>Caenorhabditis elegans</i> Metabolomics-A Review of Current Methods and Applications to Explore Metabolism in the Nematode. | Salzer L et al. | โ | 2021 | โ |
| Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in <i>Caenorhabditis elegans</i>. | Li P et al. | โ | 2021 | โ |
| Risperidone induced alterations in feeding and locomotion behavior of <i>Caenorhabditis elegans</i>. | Gaur AV et al. | โ | 2021 | โ |
| Sulforaphane Targets TRA-1/GLI Upstream of DAF-16/FOXO to Promote <i>C. elegans</i> Longevity and Healthspan. | Ji H et al. | โ | 2021 | โ |
| Superoxide dismutase 1 (SOD1) and cadmium: A three models approach to the comprehension of its neurotoxic effects. | Bovio F et al. | โ | 2021 | โ |
| The Molecular Mechanism of Antioxidation of Huolisu Oral Liquid Based on Serum Analysis and Network Analysis. | Yin Y et al. | โ | 2021 | โ |
| The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer's disease pathology: From antioxidant to epigenetic therapy. | Griรฑรกn-Ferrรฉ C et al. | โ | 2021 | โ |
| The triterpenoid ursolic acid ameliorates stress in Caenorhabditis elegans by affecting the depression-associated genes skn-1 and prdx2. | Naร J et al. | โ | 2021 | โ |
| The utilization of small non-mammals in traumatic brain injury research: A systematic review. | Zulazmi NA et al. | โ | 2021 | โ |
| Ursolic acid enhances stress resistance, reduces ROS accumulation and prolongs life span in C. elegans serotonin-deficient mutants. | Naร J et al. | โ | 2021 | โ |
| Withanone Ameliorates Stress Symptoms in Caenorhabditis Elegans by Acting through Serotonin Receptors. | Naร J et al. | โ | 2021 | โ |
| Airborne toluene exposure causes germline apoptosis and neuronal damage that promotes neurobehavioural changes in Caenorhabditis elegans. | Soares MV et al. | โ | 2020 | โ |
| Amyotrophic Lateral Sclerosis: Proteins, Proteostasis, Prions, and Promises. | McAlary L et al. | โ | 2020 | โ |
| An approach using Caenorhabditis elegans screening novel targets to suppress tumour cell proliferation. | Mao YQ et al. | โ | 2020 | โ |
| An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs. | Koslowski S et al. | โ | 2020 | โ |
| A robust and miniaturized screening platform to study natural products affecting metabolism and survival in Caenorhabditis elegans. | Zwirchmayr J et al. | โ | 2020 | โ |
| Bioelectronics for Millimeter-Sized Model Organisms. | Gonzales DL et al. | โ | 2020 | โ |
| Caenorhabditis elegans as a model system for human diseases. | Markaki M et al. | โ | 2020 | โ |
| Comprehensive phenotyping and transcriptome profiling to study nanotoxicity in <i>C. elegans</i>. | Viau C et al. | โ | 2020 | โ |
| Counteracting Environmental Chemicals with Coenzyme Q10: An Educational Primer for Use with "Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in the <i>Caenorhabditis elegans</i> Germline". | Bradford BR et al. | โ | 2020 | โ |
| Defects in CISD-1, a mitochondrial iron-sulfur protein, lower glucose level and ATP production in Caenorhabditis elegans. | Hsiung KC et al. | โ | 2020 | โ |
| Defining <i>Caenorhabditis elegans</i> as a model system to investigate lipoic acid metabolism. | Lavatelli A et al. | โ | 2020 | โ |
| Effects of Airborne Nanoparticles on the Nervous System: Amyloid Protein Aggregation, Neurodegeneration and Neurodegenerative Diseases. | von Mikecz A et al. | โ | 2020 | โ |
| Effects of low-dose chlorpyrifos on neurobehavior and potential mechanisms: A review of studies in rodents, zebrafish, and Caenorhabditis elegans. | Silva MH | โ | 2020 | โ |
| Evaluation of Carotenoids Protection Against Oxidative Stress in the Animal Model Caenorhabditis elegans. | Martorell P et al. | โ | 2020 | โ |
| Force microscopy of the <i>Caenorhabditis elegans</i> embryonic eggshell. | Krenger R et al. | โ | 2020 | โ |
| From sequence to information. | Popa O et al. | โ | 2020 | โ |
| Habituation in high-throughput genetic model organisms as a tool to investigate the mechanisms of neurodevelopmental disorders. | Kepler LD et al. | โ | 2020 | โ |
| <i>Caenorhabditis elegans</i> as a model system for studying aging-associated neurodegenerative diseases. | Van Pelt KM et al. | โ | 2020 | โ |
| <i>Caenorhabditis elegans</i> Models to Investigate the Mechanisms Underlying Tau Toxicity in Tauopathies. | Natale C et al. | โ | 2020 | โ |
| <i>Caernohabditis elegans</i> as a Model Organism to Evaluate the Antioxidant Effects of Phytochemicals. | Ayuda-Durรกn B et al. | โ | 2020 | โ |
| Identification of Flavoanoids From Finger Citron and Evaluation on Their Antioxidative and Antiaging Activities. | Luo X et al. | โ | 2020 | โ |
| Identification of Uric Acid Gluconucleoside-Ascaroside Conjugates in <i>Caenorhabditis elegans</i> by Combining Synthesis and MicroED. | Curtis BJ et al. | โ | 2020 | โ |
| Involvement of dopamine receptor in the actions of non-psychoactive phytocannabinoids. | Shrader SH et al. | โ | 2020 | โ |
| Laboratory biases hinder Eco-Evo-Devo integration: Hints from the microbial world. | Rivera-Yoshida N et al. | โ | 2020 | โ |
| Loss of egli-1, the Caenorhabditis elegans Orthologue of a Downstream Target of SMN, Leads to Abnormalities in Sensorimotor Integration. | Da Silva JD et al. | โ | 2020 | โ |
| Microfluidic Device for Microinjection of <i>Caenorhabditis elegans</i>. | Ghaemi R et al. | โ | 2020 | โ |
| Microfluidic system for Caenorhabditis elegans culture and oxygen consumption rate measurements. | Krenger R et al. | โ | 2020 | โ |
| Molecular Muscle Experiment: Hardware and Operational Lessons for Future Astrobiology Space Experiments. | Pollard AK et al. | โ | 2020 | โ |
| Omics approach reveals perturbation of metabolism and phenotype in Caenorhabditis elegans triggered by perfluorinated compounds. | Kim HM et al. | โ | 2020 | โ |
| Optimization in continuous phase-transition extraction of crude flavonoids from finger citron fruit and evaluation on their antiaging activities. | Chen H et al. | โ | 2020 | โ |
| Piperazine designer drugs elicit toxicity in the alternative in vivo model Caenorhabditis elegans. | Souto C et al. | โ | 2020 | โ |
| Piquiรก Shells (<i>Caryocar villosum</i>): A Fruit by-Product with Antioxidant and Antiaging Properties in <i>Caenorhabditis elegans</i>. | Roxo M et al. | โ | 2020 | โ |
| Silica nanoparticles enhance germ cell apoptosis by inducing reactive oxygen species (ROS) formation in Caenorhabditis elegans. | Zhang F et al. | โ | 2020 | โ |
| Surface-Related Toxicity of Polystyrene Beads to Nematodes and the Role of Food Availability. | Mueller MT et al. | โ | 2020 | โ |
| Systematic phenomics analysis of autism-associated genes reveals parallel networks underlying reversible impairments in habituation. | McDiarmid TA et al. | โ | 2020 | โ |
| The FDA-approved drugs ticlopidine, sertaconazole, and dexlansoprazole can cause morphological changes in C.ย elegans. | Galford KF et al. | โ | 2020 | โ |
| The impact of manganese on neurotransmitter systems. | Soares ATG et al. | โ | 2020 | โ |
| The Nucleus of Intestinal Cells of the Bacterivore Nematode Caenorhabditis elegans as a Sensitive Sensor of Environmental Pollutants. | Piechulek A et al. | โ | 2020 | โ |
| The Role of Neurotransmitters in the Protection of <i>Caenorhabditis Elegans</i> for <i>Salmonella</i> Infection by <i>Lactobacillus</i>. | Liu X et al. | โ | 2020 | โ |
| Use of Phycobiliproteins from Atacama Cyanobacteria as Food Colorants in a Dairy Beverage Prototype. | Galetoviฤ A et al. | โ | 2020 | โ |
| Volume holographic optical element for light sheet fluorescence microscopy. | Hsieh TY et al. | โ | 2020 | โ |
| A C. elegans Model for the Study of RAGE-Related Neurodegeneration. | Pinkas A et al. | โ | 2019 | โ |
| Advances in exploring the therapeutic potential of marine natural products. | Liang X et al. | โ | 2019 | โ |
| Air Pollution Alters Caenorhabditis elegans Development and Lifespan: Responses to Traffic-Related Nanoparticulate Matter. | Haghani A et al. | โ | 2019 | โ |
| Alleviation of symptoms of Alzheimer's disease by diminishing Aฮฒ neurotoxicity and neuroinflammation. | Yang T et al. | โ | 2019 | โ |
| An industry perspective: A streamlined screening strategy using alternative models for chemical assessment of developmental neurotoxicity. | Li J et al. | โ | 2019 | โ |
| Assessing effects of germline exposure to environmental toxicants by high-throughput screening in C. elegans. | Shin N et al. | โ | 2019 | โ |
| Automated Platform for Long-Term Culture and High-Content Phenotyping of Single C. elegans Worms. | Atakan HB et al. | โ | 2019 | โ |
| Caenorhabditis elegans and its applicability to studies on restless legs syndrome. | Chen P et al. | โ | 2019 | โ |
| C. elegans expressing D76N ฮฒ<sub>2</sub>-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis. | Faravelli G et al. | โ | 2019 | โ |
| Didymin improves UV irradiation resistance in <i>C. elegans</i>. | Zhou L et al. | โ | 2019 | โ |
| Effectively controlled microfluidic trap for spatiotemporal analysis of the electrotaxis of Caenorhabditis elegans. | Yoon S et al. | โ | 2019 | โ |
| Effect of Euphorbia factor L1 on intestinal barrier impairment and defecation dysfunction in Caenorhabditis elegans. | Zhu A et al. | โ | 2019 | โ |
| Expanding the Biological Application of Fluorescent Benzothiadiazole Derivatives: A Phenotypic Screening Strategy for Anthelmintic Drug Discovery Using <i>Caenorhabditis elegans</i>. | Cintra GAS et al. | โ | 2019 | โ |
| Gliadin Intake Causes Disruption of the Intestinal Barrier and an Increase in Germ Cell Apoptosis in A <i>Caenorhabditis Elegans</i> Model. | Min H et al. | โ | 2019 | โ |
| Global Proteomic Response of <i>Caenorhabditis elegans</i> Against PemK<sub>Sa</sub> Toxin. | Mir DA et al. | โ | 2019 | โ |
| High-Content and High-Throughput In Vivo Drug Screening Platforms Using Microfluidics. | Ben-Yakar A | โ | 2019 | โ |
| Hybrid Assembly of the Genome of the Entomopathogenic Nematode <i>Steinernema carpocapsae</i> Identifies the X-Chromosome. | Serra L et al. | โ | 2019 | โ |
| <i>Caenorhabditis elegans</i> As a Promising Alternative Model for Environmental Chemical Mixture Effect Assessment-A Comparative Study. | Wittkowski P et al. | โ | 2019 | โ |
| <i>Caenorhabditis elegans</i> as a tool for environmental risk assessment: emerging and promising applications for a "nobelized worm". | Queirรณs L et al. | โ | 2019 | โ |
| Inducing Mild Traumatic Brain Injury in C. elegans via Cavitation-Free Surface Acoustic Wave-Driven Ultrasonic Irradiation. | Miansari M et al. | โ | 2019 | โ |
| Ingredients in Zijuan Pu'er Tea Extract Alleviate ฮฒ-Amyloid Peptide Toxicity in a <i>Caenorhabditis elegans</i> Model of Alzheimer's Disease Likely through DAF-16. | Du F et al. | โ | 2019 | โ |
| In Silico Molecular Docking and In Vivo Validation with <i>Caenorhabditis elegans</i> to Discover Molecular Initiating Events in Adverse Outcome Pathway Framework: Case Study on Endocrine-Disrupting Chemicals with Estrogen and Androgen Receptors. | Jeong J et al. | โ | 2019 | โ |
| Intergenerational reproductive toxicity of chlordecone in male Caenorhabditis elegans. | Dai S et al. | โ | 2019 | โ |
| Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor. | Braun MM et al. | โ | 2019 | โ |
| Neurotoxicity of nonylphenol exposure on Caenorhabditis elegans induced by reactive oxidative species and disturbance synthesis of serotonin. | Cao X et al. | โ | 2019 | โ |
| Novel steroidal saponin isolated from Trillium tschonoskii maxim. exhibits anti-oxidative effect via autophagy induction in cellular and Caenorhabditis elegans models. | Wu AG et al. | โ | 2019 | โ |
| Protective effect of neglected plant Diplocyclos palmatus on quorum sensing mediated infection of Serratia marcescens and UV-A induced photoaging in model Caenorhabditis elegans. | Alexpandi R et al. | โ | 2019 | โ |
| Quantification of microplastics along the Caribbean Coastline of Colombia: Pollution profile and biological effects on Caenorhabditis elegans. | Acosta-Coley I et al. | โ | 2019 | โ |
| Rosmarinic acid improved antioxidant properties and healthspan via the IIS and MAPK pathways in Caenorhabditis elegans. | Lin C et al. | โ | 2019 | โ |
| Selenium Stimulates Cadmium Detoxification in Caenorhabditis elegans through Thiols-Mediated Nanoparticles Formation and Secretion. | Li LL et al. | โ | 2019 | โ |
| Simple Evaluation of <i>Listeria monocytogenes</i> Pathogenesis Using <i>Caenorhabditis elegans</i> Animal Model. | Yang KH et al. | โ | 2019 | โ |
| Steroids originating from bacterial bile acid degradation affect Caenorhabditis elegans and indicate potential risks for the fauna of manured soils. | Mendelski MN et al. | โ | 2019 | โ |
| Systematic phenomics analysis of ASD-associated genes reveals shared functions and parallel networks underlying reversible impairments in habituation learning | McDiarmid TA et al. | โ | 2019 | โ |
| Temporal Profile of Brain Gene Expression After Prey Catching Conditioning in an Anuran Amphibian. | Lewis V et al. | โ | 2019 | โ |
| The <i>in-silico</i> characterization of the <i>Caenorhabditis elegans</i> matrisome and proposal of a novel collagen classification. | Teuscher AC et al. | โ | 2019 | โ |
| Transgenerational effects of diesel particulate matter on Caenorhabditis elegans through maternal and multigenerational exposure. | Wang M et al. | โ | 2019 | โ |
| Unravelling the wound healing ability and mode of action of pyridine carboxamide oxime using Caenorhabditis elegans as potential prescreen wound model. | Pooranachithra M et al. | โ | 2019 | โ |
| Zymolytic Grain Extract (ZGE) Significantly Extends the Lifespan and Enhances the Environmental Stress Resistance of <i>Caenorhabditis elegans</i>. | Hou L et al. | โ | 2019 | โ |
| 2,2',4,4'-tetrabromodiphenyl ether induces germ cell apoptosis through oxidative stress by a MAPK-mediated p53-independent pathway. | You X et al. | โ | 2018 | โ |
| Antimicrobial blue light photoinactivation of Pseudomonas aeruginosa: Quorum sensing signaling molecules, biofilm formation and pathogenicity. | Fila G et al. | โ | 2018 | โ |
| Automated screening of C. elegans neurodegeneration mutants enabled by microfluidics and image analysis algorithms. | de Carlos Cรกceres I et al. | โ | 2018 | โ |
| Biological Concerns on the Selection of Animal Models for Teratogenic Testing. | Alves-Pimenta S et al. | โ | 2018 | โ |
| Caenorhabditis elegans: A Convenient In Vivo Model for Assessing the Impact of Food Bioactive Compounds on Obesity, Aging, and Alzheimer's Disease. | Shen P et al. | โ | 2018 | โ |
| Caenorhabditis elegans as an emerging model system in environmental epigenetics. | Weinhouse C et al. | โ | 2018 | โ |
| Caenorhabditis elegans respond to high-glucose diets through a network of stress-responsive transcription factors. | Alcรกntar-Fernรกndez J et al. | โ | 2018 | โ |
| C.el Phosphatome: A Catalogue of Actual and Pseudo Phosphatases Based on In-Silico Studies in Caenorhabditis elegans. | Fatima S et al. | โ | 2018 | โ |
| Comparative genomic analysis of the human and nematode Caenorhabditis elegans uncovers potential reproductive genes and disease associations in humans. | Kim Y et al. | โ | 2018 | โ |
| Constituent and effects of polysaccharides isolated from Sophora moorcroftiana seeds on lifespan, reproduction, stress resistance, and antimicrobial capacity in Caenorhabditis elegans. | Zhang Y et al. | โ | 2018 | โ |
| CRISPR-Cas9 human gene replacement and phenomic characterization in <i>Caenorhabditis elegans</i> to understand the functional conservation of human genes and decipher variants of uncertain significance. | McDiarmid TA et al. | โ | 2018 | โ |
| Cross-species molecular dissection across alcohol behavioral domains. | Farris SP et al. | โ | 2018 | โ |
| Di(2-ethylhexyl) phthalate and diethyl phthalate disrupt lipid metabolism, reduce fecundity and shortens lifespan of Caenorhabditis elegans. | Pradhan A et al. | โ | 2018 | โ |
| Diisopropylphenyl-imidazole (DII): A new compound that exerts anthelmintic activity through novel molecular mechanisms. | Blanco MG et al. | โ | 2018 | โ |
| Dynamic microfluidic nanocalorimetry system for measuring Caenorhabditis elegans metabolic heat. | Krenger R et al. | โ | 2018 | โ |
| Echinacoside, a phenylethanoid glycoside from Cistanche deserticola, extends lifespan of Caenorhabditis elegans and protects from Aฮฒ-induced toxicity. | Chen W et al. | โ | 2018 | โ |
| Evaluation of antioxidant and neuroprotective activities of <i>Cassia fistula</i> (L.) using the <i>Caenorhabditis elegans</i> model. | Thabit S et al. | โ | 2018 | โ |
| Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans. | Gao AW et al. | โ | 2018 | โ |
| Frailty and <i>Caenorhabditis elegans</i> as a Benchtop Animal Model for Screening Drugs Including Natural Herbs. | Matsunami K | โ | 2018 | โ |
| Fukugiside, a biflavonoid from Garcinia travancorica inhibits biofilm formation of Streptococcus pyogenes and its associated virulence factors. | Nandu TG et al. | โ | 2018 | โ |
| Genetic and cellular sensitivity of <i>Caenorhabditis elegans</i> to the chemotherapeutic agent cisplatin. | Garcรญa-Rodrรญguez FJ et al. | โ | 2018 | โ |
| How early media exposure may affect cognitive function: A review of results from observations in humans and experiments in mice. | Christakis DA et al. | โ | 2018 | โ |
| <i>Caenorhabditis elegans</i> as a Model Host to Monitor the <i>Candida</i> Infection Processes. | Elkabti AB et al. | โ | 2018 | โ |
| <i>C. elegans</i>-An Emerging Model to Study Metal-Induced RAGE-Related Pathologies. | Pinkas A et al. | โ | 2018 | โ |
| Identification of small-molecule ion channel modulators in C. elegans channelopathy models. | Jiang Q et al. | โ | 2018 | โ |
| Integrated Microfluidic Device for Drug Studies of Early <i>C. Elegans</i> Embryogenesis. | Dong L et al. | โ | 2018 | โ |
| <i>Salvia hispanica</i> L. (chia) seeds oil extracts reduce lipid accumulation and produce stress resistance in <i>Caenorhabditis elegans</i>. | Rodrigues CF et al. | โ | 2018 | โ |
| Line excitation array detection fluorescence microscopy at 0.8 million frames per second. | Martin C et al. | โ | 2018 | โ |
| Microfluidic Devices Developed for and Inspired by Thermotaxis and Chemotaxis. | Karbalaei A et al. | โ | 2018 | โ |
| Microfluidics for mechanobiology of model organisms. | Kim AA et al. | โ | 2018 | โ |
| Modeling Parkinson's Disease in C. elegans. | Cooper JF et al. | โ | 2018 | โ |
| Multimodal imaging and high-throughput image-processing for drug screening on living organisms on-chip. | Migliozzi D et al. | โ | 2018 | โ |
| Neuroprotective effect of Decalepis hamiltonii aqueous root extract and purified 2-hydroxy-4-methoxy benzaldehyde on 6-OHDA induced neurotoxicity in Caenorhabditis elegans. | Kamireddy K et al. | โ | 2018 | โ |
| New cytokinin derivatives possess UVA and UVB photoprotective effect on human skin cells and prevent oxidative stress. | Hรถnig M et al. | โ | 2018 | โ |
| Nonmammalian Models of Huntington's Disease. | Chongtham A et al. | โ | 2018 | โ |
| Preliminary characterization of the structure and immunostimulatory and anti-aging properties of the polysaccharide fraction of <i>Haematococcus pluvialis</i>. | Liu X et al. | โ | 2018 | โ |
| Recombinant buckwheat glutaredoxin intake increases lifespan and stress resistance via hsf-1 upregulation in Caenorhabditis elegans. | Li F et al. | โ | 2018 | โ |
| Resveratrol attenuates iron-induced toxicity in a chronic post-treatment paradigm in Caenorhabditis elegans. | Soares MV et al. | โ | 2018 | โ |
| Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms. | Dong L et al. | โ | 2018 | โ |
| Subcellular Nanorheology Reveals Lysosomal Viscosity as a Reporter for Lysosomal Storage Diseases. | Devany J et al. | โ | 2018 | โ |
| Synergistic Effect of Quinic Acid Derived From <i>Syzygium cumini</i> and Undecanoic Acid Against <i>Candida</i> spp. Biofilm and Virulence. | Muthamil S et al. | โ | 2018 | โ |
| The Nif3-Family Protein YqfO03 from <i>Pseudomonas syringae</i> MB03 Has Multiple Nematicidal Activities against <i>Caenorhabditis elegans</i> and <i>Meloidogyne incognita</i>. | Manan A et al. | โ | 2018 | โ |
| Toward the Synthesis and Improved Biopotential of an <i>N</i>-methylated Analog of a Proline-Rich Cyclic Tetrapeptide from Marine Bacteria. | Dahiya R et al. | โ | 2018 | โ |
| Whole-Genome Analysis of Bacillus thuringiensis Revealing Partial Genes as a Source of Novel Cry Toxins. | Sajid M et al. | โ | 2018 | โ |
| 4-Bromodiphenyl Ether Induces Germ Cell Apoptosis by Induction of ROS and DNA Damage in Caenorhabditis elegans. | You X et al. | โ | 2017 | โ |
| Activity of gallic acid and its ester derivatives in Caenorhabditis elegans and zebrafish (Danio rerio) models. | Singulani JL et al. | โ | 2017 | โ |
| Adverse Effects of Hydroalcoholic Extracts and the Major Components in the Stems of <i>Impatiens balsamina</i> L. on <i>Caenorhabditis elegans</i>. | Jiang HF et al. | โ | 2017 | โ |
| Alkyl Protocatechuate-Loaded Nanostructured Lipid Systems as a Treatment Strategy for <i>Paracoccidioides brasiliensis</i> and <i>Paracoccidioides lutzii In Vitro</i>. | Medina-Alarcรณn KP et al. | โ | 2017 | โ |
| A microfluidic diode for sorting and immobilization of Caenorhabditis elegans. | Yang L et al. | โ | 2017 | โ |
| An Elegan(t) Screen for Drug-Microbe Interactions. | Vrbanac A et al. | โ | 2017 | โ |
| An enhanced C. elegans based platform for toxicity assessment. | Xiong H et al. | โ | 2017 | โ |
| Arbutin increases <i>Caenorhabditis elegans</i> longevity and stress resistance. | Zhou L et al. | โ | 2017 | โ |
| Beyond mouse cancer models: Three-dimensional human-relevant in vitro and non-mammalian in vivo models for photodynamic therapy. | Kucinska M et al. | โ | 2017 | โ |
| Caenorhabditis elegans as a powerful alternative model organism to promote research in genetic toxicology and biomedicine. | Honnen S | โ | 2017 | โ |
| C. elegans-on-a-chip for in situ and in vivo Ag nanoparticles' uptake and toxicity assay. | Kim JH et al. | โ | 2017 | โ |
| C. elegans Vulva Induction: An In Vivo Model to Study Epidermal Growth Factor Receptor Signaling and Trafficking. | Gauthier K et al. | โ | 2017 | โ |
| Cross-reactivities of mammalian MAPKs antibodies in rotifer and copepod: Application in mechanistic studies in aquatic ecotoxicology. | Kang HM et al. | โ | 2017 | โ |
| Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles. | Perni M et al. | โ | 2017 | โ |
| Detecting and Trapping of a Single C. elegans Worm in a Microfluidic Chip for Automated Microplate Dispensing. | Desta IT et al. | โ | 2017 | โ |
| Double Stranded RNA in Human Seminal Plasma. | Zagoskin MV et al. | โ | 2017 | โ |
| Drosophila melanogaster "a potential model organism" for identification of pharmacological properties of plants/plant-derived components. | Panchal K et al. | โ | 2017 | โ |
| Effective drug combination for <i>Caenorhabditis elegans</i> nematodes discovered by output-driven feedback system control technique. | Ding X et al. | โ | 2017 | โ |
| Ephemeral-habitat colonization and neotropical species richness of Caenorhabditis nematodes. | Ferrari C et al. | โ | 2017 | โ |
| Expanding the nematode model system: The molecular basis of inflammation and infection recovery in C. elegans. | Hendricks G et al. | โ | 2017 | โ |
| Exploiting Analysis of Heterogeneity to Increase the Information Content Extracted from Fluorescence Micrographs of Transgenic Zebrafish Embryos. | Shun T et al. | โ | 2017 | โ |
| From the Cover: ZnO Nanoparticles Enhanced Germ Cell Apoptosis in Caenorhabditis elegans, in Comparison with ZnCl2. | O'Donnell B et al. | โ | 2017 | โ |
| Genetic kidney diseases: Caenorhabditis elegans as model system. | Ganner A et al. | โ | 2017 | โ |
| Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. | Adkins AE et al. | โ | 2017 | โ |
| <i>Caenorhabditis elegans</i> models of tauopathy. | Pir GJ et al. | โ | 2017 | โ |
| Imaging metals in Caenorhabditis elegans. | Aschner M et al. | โ | 2017 | โ |
| Improvement of chitinase Pachi with nematicidal activities by random mutagenesis. | Chen J et al. | โ | 2017 | โ |
| In-vivo high resolution AFM topographic imaging of Caenorhabditis elegans reveals previously unreported surface structures of cuticle mutants. | Essmann CL et al. | โ | 2017 | โ |
| Liver Disease in Alpha-1 Antitrypsin Deficiency: Current Approaches and Future Directions. | Mitchell EL et al. | โ | 2017 | โ |
| Long-range correlations and fractal dynamics in C. elegans: Changes with aging and stress. | Alves LGA et al. | โ | 2017 | โ |
| Microcystin-LR exposure induces oxidative damage in Caenorhabditis elegans: Protective effect of lutein extracted from marigold flowers. | Augusti PR et al. | โ | 2017 | โ |
| Mitochondria and MAPK cascades modulate endosulfan-induced germline apoptosis in <i>Caenorhabditis elegans</i>. | Wang J et al. | โ | 2017 | โ |
| Modeling Host-Microbiome Interactions in <i>Caenorhabditis elegans</i>. | Gerbaba TK et al. | โ | 2017 | โ |
| Natural diversity facilitates the discovery of conserved chemotherapeutic response mechanisms. | Zdraljevic S et al. | โ | 2017 | โ |
| Peptide multifunctionalized gold nanorods decrease toxicity of ฮฒ-amyloid peptide in a Caenorhabditis elegans model of Alzheimer's disease. | Morales-Zavala F et al. | โ | 2017 | โ |
| Reproductive toxicity induced by nickel nanoparticles in Caenorhabditis elegans. | Kong L et al. | โ | 2017 | โ |
| Safety assessment of nanopesticides using the roundworm Caenorhabditis elegans. | Jacques MT et al. | โ | 2017 | โ |
| Scalable electrophysiology in intact small animals with nanoscale suspended electrode arrays. | Gonzales DL et al. | โ | 2017 | โ |
| Separation, Sizing, and Quantitation of Engineered Nanoparticles in an Organism Model Using Inductively Coupled Plasma Mass Spectrometry and Image Analysis. | Johnson ME et al. | โ | 2017 | โ |
| Subcellular Redox Targeting: Bridging in Vitro and in Vivo Chemical Biology. | Long MJ et al. | โ | 2017 | โ |
| The C. elegans model in toxicity testing. | Hunt PR | โ | 2017 | โ |
| The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions. | Issi L et al. | โ | 2017 | โ |
| Toxicity evaluation of boron nitride nanospheres and water-soluble boron nitride in <i>Caenorhabditis elegans</i>. | Wang N et al. | โ | 2017 | โ |
| VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2. | Gao YH et al. | โ | 2017 | โ |
| Acrylamide induces locomotor defects and degeneration of dopamine neurons in Caenorhabditis elegans. | Li J et al. | โ | 2016 | โ |
| Aflatoxin Bโ-Induced Developmental and DNA Damage in Caenorhabditis elegans. | Feng WH et al. | โ | 2016 | โ |
| A Genome-Scale Database and Reconstruction of Caenorhabditis elegans Metabolism. | Gebauer J et al. | โ | 2016 | โ |
| A hybrid microfluidic device for on-demand orientation and multidirectional imaging of <i>C. elegans</i> organs and neurons. | Ardeshiri R et al. | โ | 2016 | โ |
| A microfluidic device for automated, high-speed microinjection of Caenorhabditis elegans. | Song P et al. | โ | 2016 | โ |
| An automated microfluidic system for screening Caenorhabditis elegans behaviors using electrotaxis. | Liu D et al. | โ | 2016 | โ |
| A novel approach using C. elegans DNA damage-induced apoptosis to characterize the dynamics of uptake transporters for therapeutic drug discoveries. | Papaluca A et al. | โ | 2016 | โ |
| Anti-amyloid compounds protect from silica nanoparticle-induced neurotoxicity in the nematode C. elegans. | Scharf A et al. | โ | 2016 | โ |
| Behavioral analysis of the huntingtin-associated protein 1 ortholog trak-1 in Caenorhabditis elegans. | Norflus F et al. | โ | 2016 | โ |
| Benefits of Strategic Small-Scale Targeted Screening. | Sharlow ER | โ | 2016 | โ |
| Betulin inhibits virulence and biofilm of Streptococcus pyogenes by suppressing ropB core regulon, sagA and dltA. | Viszwapriya D et al. | โ | 2016 | โ |
| BioSig3D: High Content Screening of Three-Dimensional Cell Culture Models. | Bilgin CC et al. | โ | 2016 | โ |
| C(16)-C(22) oxygen-bridged analogues of ceDAF-12 and LXR ligands. | Del Fueyo MC et al. | โ | 2016 | โ |
| C. elegans as a model organism for human mitochondrial associated disorders. | Maglioni S et al. | โ | 2016 | โ |
| C. elegans screening strategies to identify pro-longevity interventions. | Maglioni S et al. | โ | 2016 | โ |
| Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan. | Wang E et al. | โ | 2016 | โ |
| Chronic Exposure to Perfluorooctane Sulfonate Reduces Lifespan of Caenorhabditis elegans Through Insulin/IGF-1 Signaling. | Xu T et al. | โ | 2016 | โ |
| David and Goliath: chemical perturbation of eukaryotes by bacteria. | Ho LK et al. | โ | 2016 | โ |
| Developmental Effects of the ToxCastโข Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits. | Boyd WA et al. | โ | 2016 | โ |
| Drug screening using model systems: some basics. | Cagan R | โ | 2016 | โ |
| Gene expression profiling to investigate tyrosol-induced lifespan extension in Caenorhabditis elegans. | Caรฑuelo A et al. | โ | 2016 | โ |
| Genome Editing in C. elegans and Other Nematode Species. | Sugi T | โ | 2016 | โ |
| Glucose-induced abnormal egg-laying rate in Caenorhabditis elegans. | Teshiba E et al. | โ | 2016 | โ |
| HIV-1 Nef binds with human GCC185 protein and regulates mannose 6 phosphate receptor recycling. | Kumar M et al. | โ | 2016 | โ |
| Hydrophilic antioxidants from Andean tomato landraces assessed by their bioactivities in vitro and in vivo. | Di Paola Naranjo RD et al. | โ | 2016 | โ |
| Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model. | Mondal S et al. | โ | 2016 | โ |
| Levodopa-Induced Motor and Dopamine Receptor Changes in Caenorhabditis elegans Overexpressing Human Alpha-Synuclein. | Gupta DK et al. | โ | 2016 | โ |
| Linking Subcellular Disturbance to Physiological Behavior and Toxicity Induced by Quantum Dots in Caenorhabditis elegans. | Wang Q et al. | โ | 2016 | โ |
| Mechanism of Different Stereoisomeric Astaxanthin in Resistance to Oxidative Stress in Caenorhabditis elegans. | Liu X et al. | โ | 2016 | โ |
| Mechanisms of spreading depolarization in vertebrate and insect central nervous systems. | Spong KE et al. | โ | 2016 | โ |
| Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans. | Gupta BP et al. | โ | 2016 | โ |
| Microfluidic Device to Measure the Speed of <i>C. elegans</i> Using the Resistance Change of the Flexible Electrode. | Jung J et al. | โ | 2016 | โ |
| Microfluidics as a new tool in radiation biology. | Lacombe J et al. | โ | 2016 | โ |
| On-chip microfluidic biocommunication assay for studying male-induced demise in C. elegans hermaphrodites. | Dong L et al. | โ | 2016 | โ |
| Real-time tracking mitochondrial dynamic remodeling with two-photon phosphorescent iridium (III) complexes. | Huang H et al. | โ | 2016 | โ |
| Rotational manipulation of single cells and organisms using acoustic waves. | Ahmed D et al. | โ | 2016 | โ |
| Screening lifespan-extending drugs in Caenorhabditis elegans via label propagation on drug-protein networks. | Liu H et al. | โ | 2016 | โ |
| Stimulated Raman scattering microscopy: an emerging tool for drug discovery. | Tipping WJ et al. | โ | 2016 | โ |
| The effects of short-term hypergravity on Caenorhabditis elegans. | Saldanha JN et al. | โ | 2016 | โ |
| The genome-wide role of HSF-1 in the regulation of gene expression in Caenorhabditis elegans. | Brunquell J et al. | โ | 2016 | โ |
| The nematode Caenorhabditis elegans as an integrated toxicological tool to assess water quality and pollution. | Clavijo A et al. | โ | 2016 | โ |
| The resveratrol-enriched rice DJ526 boosts motor coordination and physical strength. | Chung HJ et al. | โ | 2016 | โ |
| A Cultivated Form of a Red Seaweed (Chondrus crispus), Suppresses ฮฒ-Amyloid-Induced Paralysis in Caenorhabditis elegans. | Sangha JS et al. | โ | 2015 | โ |
| Adsorbable organic bromine compounds (AOBr) in aquatic samples: a nematode-based toxicogenomic assessment of the exposure hazard. | Saul N et al. | โ | 2015 | โ |
| Agar-polydimethylsiloxane devices for quantitative investigation of oviposition behaviour of adult Drosophila melanogaster. | Leung JC et al. | โ | 2015 | โ |
| A microfluidic device for efficient chemical testing using Caenorhabditis elegans. | Song P et al. | โ | 2015 | โ |
| A novel cholinergic action of alcohol and the development of tolerance to that effect in Caenorhabditis elegans. | Hawkins EG et al. | โ | 2015 | โ |
| Assessing cholesterol storage in live cells and C. elegans by stimulated Raman scattering imaging of phenyl-Diyne cholesterol. | Lee HJ et al. | โ | 2015 | โ |
| A Transparent Window into Biology: A Primer on Caenorhabditis elegans. | Corsi AK et al. | โ | 2015 | โ |
| Benzo-ฮฑ-pyrene induced oxidative stress in Caenorhabditis elegans and the potential involvements of microRNA. | Wu H et al. | โ | 2015 | โ |
| Caenorhabditis elegans as a Model for Toxic Effects of Nanoparticles: Lethality, Growth, and Reproduction. | Maurer LL et al. | โ | 2015 | โ |
| Caenorhabditis elegans as an alternative in vivo model to determine oral uptake, nanotoxicity, and efficacy of melatonin-loaded lipid-core nanocapsules on paraquat damage. | Charรฃo MF et al. | โ | 2015 | โ |
| C. elegans as a model to study PTEN's regulation and function. | Liu J et al. | โ | 2015 | โ |
| Characterization of the crawling activity of Caenorhabditis elegans using a Hidden Markov model. | Lee SH et al. | โ | 2015 | โ |
| Comparative Analysis of Stress Induced Gene Expression in Caenorhabditis elegans following Exposure to Environmental and Lab Reconstituted Complex Metal Mixture. | Kumar R et al. | โ | 2015 | โ |
| Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms. | Guna A et al. | โ | 2015 | โ |
| Detection of thiol modifications by hydrogen sulfide. | Williams E et al. | โ | 2015 | โ |
| Disruption of the C. elegans Intestinal Brush Border by the Fungal Lectin CCL2 Phenocopies Dietary Lectin Toxicity in Mammals. | Stutz K et al. | โ | 2015 | โ |
| Diversity-oriented approach for chemical biology. | Lee JS et al. | โ | 2015 | โ |
| Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder. | Grotewiel M et al. | โ | 2015 | โ |
| Effects of Microcystin-LR Exposure on Spermiogenesis in Nematode Caenorhabditis elegans. | Li Y et al. | โ | 2015 | โ |
| Enhanced nematicidal potential of the chitinase pachi from Pseudomonas aeruginosa in association with Cry21Aa. | Chen L et al. | โ | 2015 | โ |
| Enhanced resolution through thick tissue with structured illumination and adaptive optics. | Thomas B et al. | โ | 2015 | โ |
| Experimental studies with nematodes in ecotoxicology: an overview. | Hรคgerbรคumer A et al. | โ | 2015 | โ |
| Germline Modification and Engineering in Avian Species. | Lee HJ et al. | โ | 2015 | โ |
| Insect-derived cecropins display activity against Acinetobacter baumannii in a whole-animal high-throughput Caenorhabditis elegans model. | Jayamani E et al. | โ | 2015 | โ |
| In vitro screening for drug repositioning. | Wilkinson GF et al. | โ | 2015 | โ |
| Mitochondrial Morphology and Fundamental Parameters of the Mitochondrial Respiratory Chain Are Altered in Caenorhabditis elegans Strains Deficient in Mitochondrial Dynamics and Homeostasis Processes. | Luz AL et al. | โ | 2015 | โ |
| Modular assembly of primary metabolic building blocks: a chemical language in C. elegans. | Schroeder FC | โ | 2015 | โ |
| Multi-endpoint, high-throughput study of nanomaterial toxicity in Caenorhabditis elegans. | Jung SK et al. | โ | 2015 | โ |
| Multi-Toxic Endpoints of the Foodborne Mycotoxins in Nematode Caenorhabditis elegans. | Yang Z et al. | โ | 2015 | โ |
| Natural photoreceptors and their application to synthetic biology. | Schmidt D et al. | โ | 2015 | โ |
| NeuCode Labeling in Nematodes: Proteomic and Phosphoproteomic Impact of Ascaroside Treatment in Caenorhabditis elegans. | Rhoads TW et al. | โ | 2015 | โ |
| Optofluidic holographic microscopy with custom field of view (FoV) using a linear array detector. | Bianco V et al. | โ | 2015 | โ |
| Perturbation of cellular mechanistic system by silver nanoparticle toxicity: Cytotoxic, genotoxic and epigenetic potentials. | Dubey P et al. | โ | 2015 | โ |
| Protective Effects of Bovine Serum Albumin on Superparamagnetic Iron Oxide Nanoparticles Evaluated in the Nematode <i>Caenorhabditis elegans</i>. | Gonzalez-Moragas L et al. | โ | 2015 | โ |
| Quantification of Glutathione in Caenorhabditis elegans. | Caito SW et al. | โ | 2015 | โ |
| Reproductive Toxicity of Endosulfan: Implication From Germ Cell Apoptosis Modulated by Mitochondrial Dysfunction and Genotoxic Response Genes in Caenorhabditis elegans. | Du H et al. | โ | 2015 | โ |
| Seahorse Xfe 24 Extracellular Flux Analyzer-Based Analysis of Cellular Respiration in Caenorhabditis elegans. | Luz AL et al. | โ | 2015 | โ |
| Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. | Teixeira-Castro A et al. | โ | 2015 | โ |
| Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives. | Yamamuro D et al. | โ | 2015 | โ |
| Synthetic DAF-12 modulators with potential use in controlling the nematode life cycle. | Dansey MV et al. | โ | 2015 | โ |
| The burrowing behavior of the nematode Caenorhabditis elegans: a new assay for the study of neuromuscular disorders. | Beron C et al. | โ | 2015 | โ |
| The toxicity of crude 4-methylcyclohexanemethanol (MCHM): review of experimental data and results of predictive models for its constituents and a putative metabolite. | Paustenbach DJ et al. | โ | 2015 | โ |
| Whole-animal mounts of Caenorhabditis elegans for 3D imaging using atomic force microscopy. | Allen MJ et al. | โ | 2015 | โ |
| Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotyping. | Treweek JB et al. | โ | 2015 | โ |
| A fucose containing polymer-rich fraction from the brown alga Ascophyllum nodosum mediates lifespan increase and thermal-tolerance in Caenorhabditis elegans, by differential effects on gene and protein expression. | Kandasamy S et al. | โ | 2014 | โ |
| Antiapoptotic Bcl-2 homolog CED-9 in Caenorhabditis elegans: dynamics of BH3 and CED-4 binding regions and comparison with mammalian antiapoptotic Bcl-2 proteins. | Modi V et al. | โ | 2014 | โ |
| Antioxidant activity, delayed aging, and reduced amyloid-ฮฒ toxicity of methanol extracts of tea seed pomace from Camellia tenuifolia. | Wei CC et al. | โ | 2014 | โ |
| Assessment of selenium toxicity on the life cycle of Caenorhabditis elegans. | Li WH et al. | โ | 2014 | โ |
| Automated, high-throughput, motility analysis in Caenorhabditis elegans and parasitic nematodes: Applications in the search for new anthelmintics. | Buckingham SD et al. | โ | 2014 | โ |
| Benzofuran-chalcone hybrids as potential multifunctional agents against Alzheimer's disease: synthesis and in vivo studies with transgenic Caenorhabditis elegans. | Sashidhara KV et al. | โ | 2014 | โ |
| Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans. | Ullrich M et al. | โ | 2014 | โ |
| Caenorhabditis elegans in regenerative medicine: a simple model for a complex discipline. | Aitlhadj L et al. | โ | 2014 | โ |
| C. elegans in high-throughput drug discovery. | O'Reilly LP et al. | โ | 2014 | โ |
| Characterization of the reniform nematode genome by shotgun sequencing. | Nyaku ST et al. | โ | 2014 | โ |
| Chronic exposure to perfluorooctane sulfonate induces behavior defects and neurotoxicity through oxidative damages, in vivo and in vitro. | Chen N et al. | โ | 2014 | โ |
| Crystal structure of a nematode-infecting virus. | Guo YR et al. | โ | 2014 | โ |
| Curcumin-mediated oxidative stress resistance in Caenorhabditis elegans is modulated by age-1, akt-1, pdk-1, osr-1, unc-43, sek-1, skn-1, sir-2.1, and mev-1. | Yu CW et al. | โ | 2014 | โ |
| Cyanobacterial xenobiotics as evaluated by a Caenorhabditis elegans neurotoxicity screening test. | Ju J et al. | โ | 2014 | โ |
| Dispersed crude oil amplifies germ cell apoptosis in Caenorhabditis elegans, followed a CEP-1-dependent pathway. | Polli JR et al. | โ | 2014 | โ |
| Effects of 5'-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans. | Rooney JP et al. | โ | 2014 | โ |
| Elemental bioimaging of manganese uptake in C. elegans. | Brinkhaus SG et al. | โ | 2014 | โ |
| Evaluation and identification of reliable reference genes for toxicological study in Caenorhabditis elegans. | Wu H et al. | โ | 2014 | โ |
| Evaluation of the toxicity of 5-aryl-2-aminoimidazole-based biofilm inhibitors against eukaryotic cell lines, bone cells and the nematode Caenorhabditis elegans. | Steenackers H et al. | โ | 2014 | โ |
| Evolutionary profiling reveals the heterogeneous origins of classes of human disease genes: implications for modeling disease genetics in animals. | Maxwell EK et al. | โ | 2014 | โ |
| Genetic revelation of hexavalent chromium toxicity using Caenorhabditis elegans as a biosensor. | Saikia SK et al. | โ | 2014 | โ |
| Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases. | Sin O et al. | โ | 2014 | โ |
| Green Tea Extract Induces the Resistance of Caenorhabditis elegans against Oxidative Stress. | Abbas S et al. | โ | 2014 | โ |
| Ida-1, the Caenorhabditis elegans orthologue of mammalian diabetes autoantigen IA-2, potentially acts as a common modulator between Parkinson's disease and Diabetes: role of Daf-2/Daf-16 insulin like signalling pathway. | Fatima S et al. | โ | 2014 | โ |
| Imaging lipid metabolism in live Caenorhabditis elegans using fingerprint vibrations. | Wang P et al. | โ | 2014 | โ |
| LC-MS proteomics analysis of the insulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism. | Depuydt G et al. | โ | 2014 | โ |
| Mechanism of longevity extension of Caenorhabditis elegans induced by pentagalloyl glucose isolated from eucalyptus leaves. | Chen Y et al. | โ | 2014 | โ |
| MORPHIN: a web tool for human disease research by projecting model organism biology onto a human integrated gene network. | Hwang S et al. | โ | 2014 | โ |
| Necrotic cell death in Caenorhabditis elegans. | Nikoletopoulou V et al. | โ | 2014 | โ |
| Nematode phospholipid metabolism: an example of closing the genome-structure-function circle. | Lee SG et al. | โ | 2014 | โ |
| Non-microfluidic methods for imaging live C. elegans. | Luke CJ et al. | โ | 2014 | โ |
| Polysaccharides from medicinal herbs as potential therapeutics for aging and age-related neurodegeneration. | Li H et al. | โ | 2014 | โ |
| Questioning the preclinical paradigm: natural, extreme biology as an alternative discovery platform. | Buffenstein R et al. | โ | 2014 | โ |
| Selenite protects Caenorhabditis elegans from oxidative stress via DAF-16 and TRXR-1. | Li WH et al. | โ | 2014 | โ |
| Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways. | O'Reilly LP et al. | โ | 2014 | โ |
| WormNet v3: a network-assisted hypothesis-generating server for Caenorhabditis elegans. | Cho A et al. | โ | 2014 | โ |
| 27-Nor-ฮ(4)-dafachronic acid is a synthetic ligand of Caenorhabditis elegans DAF-12 receptor. | Samaja GA et al. | โ | 2013 | โ |
| An automated microfluidic multiplexer for fast delivery of C. elegans populations from multiwells. | Ghorashian N et al. | โ | 2013 | โ |
| A synergistic approach towards understanding the functional significance of dopamine receptor interactions. | Pandey P et al. | โ | 2013 | โ |
| Biochemical and high throughput microscopic assessment of fat mass in Caenorhabditis elegans. | Pino EC et al. | โ | 2013 | โ |
| Caenorhabditis elegans-based in vivo screening of bioactives from marine sponge-associated bacteria against Vibrio alginolyticus. | Durai S et al. | โ | 2013 | โ |
| Contributions of altered permeability of intestinal barrier and defecation behavior to toxicity formation from graphene oxide in nematode Caenorhabditis elegans. | Wu Q et al. | โ | 2013 | โ |
| Current drug targets for helminthic diseases. | Rana AK et al. | โ | 2013 | โ |
| Deglycosylation is a key step in biotransformation and lifespan effects of quercetin-3-O-glucoside in Caenorhabditis elegans. | Dueรฑas M et al. | โ | 2013 | โ |
| Effect of nanoparticles on the biochemical and behavioral aging phenotype of the nematode Caenorhabditis elegans. | Scharf A et al. | โ | 2013 | โ |
| High concentration of vitamin E decreases thermosensation and thermotaxis learning and the underlying mechanisms in the nematode Caenorhabditis elegans. | Li Y et al. | โ | 2013 | โ |
| Involvement of AAT transporters in methylmercury toxicity in Caenorhabditis elegans. | Caito SW et al. | โ | 2013 | โ |
| Meiotic development in Caenorhabditis elegans. | Lui DY et al. | โ | 2013 | โ |
| Metal-induced neurodegeneration in C. elegans. | Chen P et al. | โ | 2013 | โ |
| Micro-electro-fluidic grids for nematodes: a lens-less, image-sensor-less approach for on-chip tracking of nematode locomotion. | Liu P et al. | โ | 2013 | โ |
| Microfluidics-enabled method to identify modes of Caenorhabditis elegans paralysis in four anthelmintics. | Lycke R et al. | โ | 2013 | โ |
| Microfluidic tools for developmental studies of small model organisms--nematodes, fruit flies, and zebrafish. | Hwang H et al. | โ | 2013 | โ |
| Midgut-enriched receptor protein tyrosine phosphatase PTP52F is required for Drosophila development during larva-pupa transition. | Santhanam A et al. | โ | 2013 | โ |
| Nanosilver suppresses growth and induces oxidative damage to DNA in Caenorhabditis elegans. | Hunt PR et al. | โ | 2013 | โ |
| Overexpression of an antimicrobial peptide derived from C. elegans using an aggregation-prone protein coexpression system. | Tomisawa S et al. | โ | 2013 | โ |
| Rational design of multifunctional upconversion nanocrystals/polymer nanocomposites for cisplatin (IV) delivery and biomedical imaging. | Ma P et al. | โ | 2013 | โ |
| Small-molecule mechanism of action studies in Caenorhabditis elegans. | Zlotkowski K et al. | โ | 2013 | โ |
| Small-molecule-mediated axonal branching in Caenorhabditis elegans. | Zlotkowski K et al. | โ | 2013 | โ |
| Study of zalema grape pomace: phenolic composition and biological effects in Caenorhabditis elegans. | Jara-Palacios MJ et al. | โ | 2013 | โ |
| The humankind genome: from genetic diversity to the origin of human diseases. | Belizรกrio JE | โ | 2013 | โ |
| Worms under stress: C. elegans stress response and its relevance to complex human disease and aging. | Rodriguez M et al. | โ | 2013 | โ |
| Alzheimer's disease models and functional genomics-How many needles are there in the haystack? | Gรถtz J et al. | โ | 2012 | โ |
| A microfluidic device for whole-animal drug screening using electrophysiological measures in the nematode C. elegans. | Lockery SR et al. | โ | 2012 | โ |
| Chemosensory cue conditioning with stimulants in a Caenorhabditis elegans animal model of addiction. | Musselman HN et al. | โ | 2012 | โ |
| Drosophila as a model to study the genetic mechanisms of obesity-associated heart dysfunction. | Diop SB et al. | โ | 2012 | โ |
| Engineered unnatural animals: tools for multicellular biochemistry. | Mehl RA | โ | 2012 | โ |
| Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems. | Stowe SD et al. | โ | 2012 | โ |
| Genome-Wide Analyses of Metal Responsive Genes in Caenorhabditis elegans. | Caito S et al. | โ | 2012 | โ |
| <i>C. elegans</i> and Neurodegeneration <i>In Caenorhabditis Elegans: Anatomy, Life Cycles and Biological Functions</i>. | Martinez-Finley EJ et al. | โ | 2012 | โ |
| In vivo antioxidant activities of essential oils and their constituents from leaves of the Taiwanese Cinnamomum osmophloeum. | Hsu FL et al. | โ | 2012 | โ |
| Laterally orienting C. elegans using geometry at microscale for high-throughput visual screens in neurodegeneration and neuronal development studies. | Cรกceres Ide C et al. | โ | 2012 | โ |
| Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against ฮฒ-amyloid toxicity in transgenic Caenorhabditis elegans. | Sangha JS et al. | โ | 2012 | โ |
| Matching experiments across species using expression values and textual information. | Wise A et al. | โ | 2012 | โ |
| Meta-Analysis of Global Transcriptomics Suggests that Conserved Genetic Pathways are Responsible for Quercetin and Tannic Acid Mediated Longevity in C. elegans. | Pietsch K et al. | โ | 2012 | โ |
| Monascin from red mold dioscorea as a novel antidiabetic and antioxidative stress agent in rats and Caenorhabditis elegans. | Shi YC et al. | โ | 2012 | โ |
| Monascus-fermented dioscorea enhances oxidative stress resistance via DAF-16/FOXO in Caenorhabditis elegans. | Shi YC et al. | โ | 2012 | โ |
| Novel structural arrangement of nematode cystathionine ฮฒ-synthases: characterization of Caenorhabditis elegans CBS-1. | Vozdek R et al. | โ | 2012 | โ |
| Role of the ubiquitin-proteasome system in nervous system function and disease: using C. elegans as a dissecting tool. | Baptista MS et al. | โ | 2012 | โ |
| Serotonin circuits and anxiety: what can invertebrates teach us? | Curran KP et al. | โ | 2012 | โ |
| Studies toward the unique pederin family member psymberin: structure-activity relationships, biochemical studies, and genetics identify the mode-of-action of psymberin. | Wu CY et al. | โ | 2012 | โ |
| The Caenorhabditis elegans DAF-12 nuclear receptor: structure, dynamics, and interaction with ligands. | Alvarez LD et al. | โ | 2012 | โ |
| The Caenorhabiditis elegans model as a reliable tool in neurotoxicology. | Avila D et al. | โ | 2012 | โ |
| The role of mycelium production and a MAPK-mediated immune response in the C. elegans-Fusarium model system. | Muhammed M et al. | โ | 2012 | โ |
| WormScan: a technique for high-throughput phenotypic analysis of Caenorhabditis elegans. | Mathew MD et al. | โ | 2012 | โ |
| Anti-biofilm compounds derived from marine sponges. | Stowe SD et al. | โ | 2011 | โ |
| Biosafety assessment of Gd@C82(OH)22 nanoparticles on Caenorhabditis elegans. | Zhang W et al. | โ | 2011 | โ |
| Cell biology. Yeast informs Alzheimer's disease. | McGurk L et al. | โ | 2011 | โ |
| Chemistry and the worm: Caenorhabditis elegans as a platform for integrating chemical and biological research. | Hulme SE et al. | โ | 2011 | โ |
| Comparative toxicology of mercurials in Caenorhabditis elegans. | McElwee MK et al. | โ | 2011 | โ |
| Discovering the targets of drugs via computational systems biology. | Chua HN et al. | โ | 2011 | โ |
| Dissection of genetic pathways in C. elegans. | Wang Z et al. | โ | 2011 | โ |
| Effects of O-methylated metabolites of quercetin on oxidative stress, thermotolerance, lifespan and bioavailability on Caenorhabditis elegans. | Surco-Laos F et al. | โ | 2011 | โ |
| Expanding the genetic code of an animal. | Greiss S et al. | โ | 2011 | โ |
| Full assessment of fate and physiological behavior of quantum dots utilizing Caenorhabditis elegans as a model organism. | Qu Y et al. | โ | 2011 | โ |
| Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases. | Martinez-Finley EJ et al. | โ | 2011 | โ |
| Lens-free optical tomographic microscope with a large imaging volume on a chip. | Isikman SO et al. | โ | 2011 | โ |
| Measuring Caenorhabditis elegans life span in 96 well microtiter plates. | Solis GM et al. | โ | 2011 | โ |
| Microfluidic chamber arrays for whole-organism behavior-based chemical screening. | Chung K et al. | โ | 2011 | โ |
| Nematode and snail metallothioneins. | Hรถckner M et al. | โ | 2011 | โ |
| Oral fatty acid signaling and intestinal lipid processing: support and supposition. | Mattes RD | โ | 2011 | โ |
| Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms. | Martinez-Finley EJ et al. | โ | 2011 | โ |
| Screening for microbial metabolites affecting phenotype of Caenorhabditis elegans. | Yamamuro D et al. | โ | 2011 | โ |
| Supplemental cellular protection by a carotenoid extends lifespan via Ins/IGF-1 signaling in Caenorhabditis elegans. | Yazaki K et al. | โ | 2011 | โ |
| Tasco(ยฎ), a product of Ascophyllum nodosum, imparts thermal stress tolerance in Caenorhabditis elegans. | Kandasamy S et al. | โ | 2011 | โ |
| The ameliorative and toxic effects of selenite on Caenorhabditis elegans. | Li WH et al. | โ | 2011 | โ |
| The Phosphobase Methylation Pathway in <i>Caernorhabditis elegans</i>: A New Route to Phospholipids in Animals. | Lee SG et al. | โ | 2011 | โ |
| Thermodynamic evaluation of ligand binding in the plant-like phosphoethanolamine methyltransferases of the parasitic nematode Haemonchus contortus. | Lee SG et al. | โ | 2011 | โ |
| Using C. elegans for antimicrobial drug discovery. | Desalermos A et al. | โ | 2011 | โ |
| A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. | Yen K et al. | โ | 2010 | โ |
| A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay. | Boyd WA et al. | โ | 2010 | โ |
| Antipsychotic drugs activate the C. elegans akt pathway via the DAF-2 insulin/IGF-1 receptor. | Weeks KR et al. | โ | 2010 | โ |
| A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans. | Burns AR et al. | โ | 2010 | โ |
| ASNA-1 activity modulates sensitivity to cisplatin. | Hemmingsson O et al. | โ | 2010 | โ |
| Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin ฮฑ1-antitrypsin Z. | Gosai SJ et al. | โ | 2010 | โ |
| Automatic identification of Caenorhabditis elegans in population images by shape energy features. | Ochoa D et al. | โ | 2010 | โ |
| A worm rich in protein: Quantitative, differential, and global proteomics in Caenorhabditis elegans. | Schrimpf SP et al. | โ | 2010 | โ |
| Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities. | Allard P et al. | โ | 2010 | โ |
| Caenorhabditis elegans generates biologically relevant levels of genotoxic metabolites from aflatoxin B1 but not benzo[a]pyrene in vivo. | Leung MC et al. | โ | 2010 | โ |
| Chemical enhancement of torsinA function in cell and animal models of torsion dystonia. | Cao S et al. | โ | 2010 | โ |
| Color and monochrome lensless on-chip imaging of Caenorhabditis elegans over a wide field-of-view. | Isikman SO et al. | โ | 2010 | โ |
| Electrotaxis of Caenorhabditis elegans in a microfluidic environment. | Rezai P et al. | โ | 2010 | โ |
| Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. | Keowkase R et al. | โ | 2010 | โ |
| Gene-environment interactions: neurodegeneration in non-mammals and mammals. | Aschner M et al. | โ | 2010 | โ |
| High-throughput screening and small animal models, where are we? | Giacomotto J et al. | โ | 2010 | โ |
| In vivo RNAi: today and tomorrow. | Perrimon N et al. | โ | 2010 | โ |
| Label-free quantitative analysis of lipid metabolism in living Caenorhabditis elegans. | Le TT et al. | โ | 2010 | โ |
| Medium- and high-throughput screening of neurotoxicants using C. elegans. | Boyd WA et al. | โ | 2010 | โ |
| Natural product mode of action (MOA) studies: a link between natural and synthetic worlds. | La Clair JJ | โ | 2010 | โ |
| Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans. | Keowkase R et al. | โ | 2010 | โ |
| Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology. | Chaudhaery SS et al. | โ | 2010 | โ |
| Quantitative proteomics by metabolic labeling of model organisms. | Gouw JW et al. | โ | 2010 | โ |
| Resveratrol attenuates radiation damage in Caenorhabditis elegans by preventing oxidative stress. | Ye K et al. | โ | 2010 | โ |
| Revealing and avoiding bias in semantic similarity scores for protein pairs. | Wang J et al. | โ | 2010 | โ |
| Shedding new light on lipid biology with coherent anti-Stokes Raman scattering microscopy. | Le TT et al. | โ | 2010 | โ |
| Utility of Caenorhabditis elegans in high throughput neurotoxicological research. | Helmcke KJ et al. | โ | 2010 | โ |
| Animal models for Alzheimer's disease and frontotemporal dementia: a perspective. | Gรถtz J et al. | โ | 2009 | โ |
| A shortcut to identifying small molecule signals that regulate behavior and development in Caenorhabditis elegans. | Pungaliya C et al. | โ | 2009 | โ |
| A transfer-less, multi-well liquid culture feeding system for screening small molecules that affect the longevity of Caenorhabditis elegans. | Fitzgerald V et al. | โ | 2009 | โ |
| Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy. | Giacomotto J et al. | โ | 2009 | โ |
| Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay. | Okoli I et al. | โ | 2009 | โ |
| In Caenorhabditis elegans nanoparticle-bio-interactions become transparent: silica-nanoparticles induce reproductive senescence. | Pluskota A et al. | โ | 2009 | โ |
| Non-Linear Optical Imaging of Obesity-Related Health Risks: Review. | Le TT et al. | โ | 2009 | โ |
| Synthesis and biological activity of the (25R)-cholesten-26-oic acids--ligands for the hormonal receptor DAF-12 in Caenorhabditis elegans. | Martin R et al. | โ | 2009 | โ |
| The use of gene array technology and proteomics in the search of new targets of diseases for therapeutics. | Ferrer-Alcรณn M et al. | โ | 2009 | โ |
| A C. elegans-based, whole animal, in vivo screen for the identification of antifungal compounds. | Tampakakis E et al. | โ | 2008 | โ |
| Beyond induced mutants: using worms to study natural variation in genetic pathways. | Kammenga JE et al. | โ | 2008 | โ |
| Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. | Leung MC et al. | โ | 2008 | โ |
| Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? | Dobson PD et al. | โ | 2008 | โ |
| Evolutionary conservation of drug action on lipoprotein metabolism-related targets. | Hihi AK et al. | โ | 2008 | โ |
| <i>Caenorhabditis elegans</i> as a Biological Model for Multilevel Biomarker Analysis in Environmental Toxicology and Risk Assessment. | Choi J | โ | 2008 | โ |
| Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. | Kampkรถtter A et al. | โ | 2008 | โ |
| Label-free cell-based assay using localized surface plasmon resonance biosensor. | Endo T et al. | โ | 2008 | โ |
| Neurovascular signalling defects in neurodegeneration. | Zacchigna S et al. | โ | 2008 | โ |
| Tyrosine phosphoproteomics and identification of substrates of protein tyrosine phosphatase dPTP61F in Drosophila S2 cells by mass spectrometry-based substrate trapping strategy. | Chang YC et al. | โ | 2008 | โ |
| Use of non-mammalian alternative models for neurotoxicological study. | Peterson RT et al. | โ | 2008 | โ |
| Visualization of protein interactions in living Caenorhabditis elegans using bimolecular fluorescence complementation analysis. | Shyu YJ et al. | โ | 2008 | โ |
| A computational model for C. elegans locomotory behavior: application to multiworm tracking. | Roussel N et al. | โ | 2007 | โ |
| Caenorhabditis elegans as a model system for Parkinson's disease. | Schmidt E et al. | โ | 2007 | โ |
| Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans. | Balamurugan K et al. | โ | 2007 | โ |
| Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans. | Kampkรถtter A et al. | โ | 2007 | โ |
| Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans. | Kampkรถtter A et al. | โ | 2007 | โ |
| Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal. | Ayyadevara S et al. | โ | 2007 | โ |
| Metabotyping of Caenorhabditis elegans reveals latent phenotypes. | Blaise BJ et al. | โ | 2007 | โ |
| Microfluidic system for on-chip high-throughput whole-animal sorting and screening at subcellular resolution. | Rohde CB et al. | โ | 2007 | โ |
| Non-developmentally programmed cell death in Caenorhabditis elegans. | Kourtis N et al. | โ | 2007 | โ |
| Phosphoethanolamine N-methyltransferase (PMT-1) catalyses the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans. | Brendza KM et al. | โ | 2007 | โ |
| Recent progress in the development of RNA interference for plant parasitic nematodes. | Lilley CJ et al. | โ | 2007 | โ |
| The Concept Paper on the Helminth Drug Initiative. Onchocerciasis/lymphatic filariasis and schistosomiasis: opportunities and challenges for the discovery of new drugs/diagnostics. | Hudson A et al. | โ | 2007 | โ |
| Universal strategies in research and drug discovery based on protein-fragment complementation assays. | Michnick SW et al. | โ | 2007 | โ |
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