Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder.
paper
Cited
Public
Unavailable
- Authors
- Xie, Pingxing; Kranzler, Henry R; Poling, James; Stein, Murray B; Anton, Raymond F; Farrer, Lindsay A; Gelernter, Joel
- Year
- 2010
- Journal
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- PMID
- 20393453
- DOI
- 10.1038/npp.2010.37
- PMCID
- PMC2946626
FKBP5 regulates the cortisol-binding affinity and nuclear translocation of the glucocorticoid receptor. Polymorphisms at the FKBP5 locus have been associated with increased recurrence risk of depressive episodes and rapid response to antidepressant treatment. A recent study showed that FKBP5 genotypes moderated the risk of post-traumatic stress disorder (PTSD) symptoms associated with childhood maltreatment. One thousand one hundred forty-three European Americans (EAs) and 1284 African Americans (AAs) recruited for studies of the genetics of substance dependence were also screened for lifetime PTSD. Four single-nucleotide polymorphisms (SNPs) in FKBP5, rs3800373, rs9296158, rs1360780, and rs9470080, were genotyped on the complete sample. Logistic regression analyses were performed to explore the interactive effect of FKBP5 polymorphisms and childhood adversity on the risk for PTSD. After correction for multiple testing, childhood adversity significantly increased the risk for PTSD. FKBP5 genotypes were not associated with the development of the disorder. In AAs, one of the SNPs, rs9470080, moderated the risk of PTSD that was associated with childhood abuse. Without childhood adverse experiences, participants with the TT genotype of this SNP had the lowest risk for PTSD, whereas they had the highest risk for PTSD after childhood adversity exposure. In addition, in EAs, alcohol dependence was observed to interact with childhood adverse experiences, and also FKBP5 polymorphisms, to increase the risk for PTSD. This study provides further evidence of a gene x environment effect of FKBP5 and childhood abuse on the risk for PTSD in AAs. Further study is required in other populations.
Figure 1
Linkage disequilibrium plots of rs3800373, rs9296158, rs1360780, and rs9470080 in EA population (a) and AA population (b). The linkage disequilibrium is depicted as r2.
Figure 2
The genotype of rs9470080 interacted with childhood adversity to modify risk for posttraumatic stress disorder (PTSD) in AA individuals. The numbers of subjects with PTSD of the total numbers of participants in the group are shown. Results indicated that AAs homozygous for the T allele at rs9470080 had reduced risk of PTSD without exposure to childhood adversity, and greater risk of PTSD when exposed to childhood adversity, than the other two genotype groups.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Biological and neurocognitive correlates of comorbid post-traumatic stress disorder and alcohol use disorder: a systematic review. | Towers EE et al. | β | 2026 | β |
| Central amygdala <i>Fkbp5</i> expression correlates with faster submission and ethanol self-administration reacquisition: Benztropine reduces ethanol relapse-like reacquisition in stressed rats. | Bertotto LB et al. | β | 2026 | β |
| Unraveling Complex Interactions Mechanisms Linking PTSD and Chronic Diseases. | Muniz Gomes CC et al. | β | 2026 | β |
| An Update on the Psychiatric Genomics of Posttraumatic Stress Disorder (PTSD). | Norrholm SD | β | 2025 | β |
| Influence of genetic polymorphism and trauma on cortical structures and PTSD severity: Imaging genetics generalized structured component analysis. | Jin MJ et al. | β | 2025 | β |
| <i>FKBP5/</i>FKBP51-mediated signaling pathways in neuropsychiatric diseases: Insights for biomarker development and targeted therapies. | Liu Y et al. | β | 2025 | β |
| The relationship between childhood trauma, rs1360780 genotypes, <i>FKBP5</i> intron 7 methylation and posttraumatic stress disorder in women who have experienced rape. | NΓΆthling J et al. | β | 2025 | β |
| The rs1360780 Variant of <i>FKBP5</i>: Genetic Variation, Epigenetic Regulation, and Behavioral Phenotypes. | Arancibia M et al. | β | 2025 | β |
| Gene-environment interaction: why genetic enhancement might never be distributed fairly. | Prince S | β | 2024 | β |
| Serotonin Transporter (SLC6A4) and FK506-Binding Protein 5 (FKBP5) Genotype and Methylation Relationships with Response to Meditation in Veterans with PTSD. | Lee A et al. | β | 2024 | β |
| Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism. | Bordes J et al. | β | 2024 | β |
| Structure and function of the TPR-domain immunophilins FKBP51 and FKBP52 in normal physiology and disease. | Soto OB et al. | β | 2024 | β |
| An Expert-guided Hierarchical Graph Attention Network for Post-traumatic Stress Disorder Highly-associative Genetic Biomarkers Identification | Zhang Q et al. | β | 2023 | β |
| FKBP5 inhibitors modulate alcohol drinking and trauma-related behaviors in a model of comorbid post-traumatic stress and alcohol use disorder. | Cruz B et al. | β | 2023 | β |
| <i>FKBP5</i> genetic variants are associated with respiratory- and sleep-related parameters in Chinese patients with obstructive sleep apnea. | Wang A et al. | β | 2023 | β |
| Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma. | Fritz M et al. | β | 2023 | β |
| Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery. | Malekpour M et al. | β | 2023 | β |
| Sex-specific and opposed effects of FKBP51 in glutamatergic and GABAergic neurons: Implications for stress susceptibility and resilience. | van Doeselaar L et al. | β | 2023 | β |
| Trauma Matters: Integrating Genetic and Environmental Components of PTSD. | Marchese S et al. | β | 2023 | β |
| Childhood adversity patterns differentially cluster with mental disorders and socioeconomic indicators in a large Swiss community sample. | Xu Y et al. | β | 2022 | β |
| FKBP51 modulates hippocampal size and function in post-translational regulation of Parkin. | Qiu B et al. | β | 2022 | β |
| Methylation of genes and regulation of inflammatory processes on emotional response in young adults with alcoholic parents. | Scholl JL et al. | β | 2022 | β |
| Physiological Genomics Plays a Crucial Role in Response to Stressful Life Events, the Development of Aggressive Behaviours, and Post-Traumatic Stress Disorder (PTSD). | Magwai T et al. | β | 2022 | β |
| Analysis of the cerebellar molecular stress response led to first evidence of a role for FKBP51 in brain FKBP52 expression in mice and humans. | Herrmann L et al. | β | 2021 | β |
| Association of CRP genetic variation with symptomatology, cognitive function, and circulating proinflammatory markers in civilian women with PTSD. | Otsuka T et al. | β | 2021 | β |
| Hypothalamic stress systems in mood disorders. | Holsboer F et al. | β | 2021 | β |
| Maternal posttraumatic stress and FKBP5 Genotype interact to predict trauma-related symptoms in preschool-age offspring. | Pereira DMBP et al. | β | 2021 | β |
| Myelination defects in the medial prefrontal cortex of Fkbp5 knockout mice. | Choi K et al. | β | 2021 | β |
| The <i>ADCYAP1R1</i> Gene Is Correlated With Posttraumatic Stress Disorder Symptoms Through Diverse Epistases in a Traumatized Chinese Population. | Wang L et al. | β | 2021 | β |
| Three-way interaction effects of early life stress, positive parenting and FKBP5 in the development of depressive symptoms in a general population. | Keijser R et al. | β | 2021 | β |
| Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study. | Brandt J et al. | β | 2020 | β |
| Childhood Adversities and Salivary Cortisol Responses to the Trier Social Stress Test: A Systematic Review of Studies Using the Children Trauma Questionnaire (CTQ). | Lai CLJ et al. | β | 2020 | β |
| Correlation between hypothalamic-pituitary-adrenal axis gene polymorphisms and posttraumatic stress disorder symptoms. | Zhang K et al. | β | 2020 | β |
| Enduring neuroimmunological consequences of developmental experiences: From vulnerability to resilience. | Reddaway J et al. | β | 2020 | β |
| Impacts of FKBP5 variants on large-scale brain network connectivity in healthy adults. | Zhang H et al. | β | 2020 | β |
| Interpersonal childhood adversity and stress generation in adolescence: Moderation by HPA axis multilocus genetic variation. | Huang M et al. | β | 2020 | β |
| Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders. | Notaras M et al. | β | 2020 | β |
| Neuroimmunological effects of early life experiences. | Brydges NM et al. | β | 2020 | β |
| Neurophysiology and Psychopathology Underlying PTSD and Recent Insights into the PTSD Therapies-A Comprehensive Review. | Aliev G et al. | β | 2020 | β |
| The Pathways between Cortisol-Related Regulation Genes and PTSD Psychotherapy. | Castro-Vale I et al. | β | 2020 | β |
| Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism. | Kapoor M et al. | β | 2019 | β |
| Animal models of PTSD: a challenge to be met. | Richter-Levin G et al. | β | 2019 | β |
| A review of epigenetic contributions β¨to post-traumatic stress disorderβ©. | Howie H et al. | β | 2019 | β |
| Attachment style moderates effects of <i>FKBP5</i> polymorphisms and childhood abuse on post-traumatic stress symptoms: Results from the National Health and Resilience in Veterans Study. | Tamman AJF et al. | β | 2019 | β |
| FKBP5 Genotype Linked to Combined PTSD-Depression Symptom in Chinese Earthquake Survivors. | Li G et al. | β | 2019 | β |
| Genetics of Resilience: Gene-by-Environment Interaction Studies as a Tool to Dissect Mechanisms of Resilience. | Elbau IG et al. | β | 2019 | β |
| GxE effects of FKBP5 and traumatic life events on PTSD: A meta-analysis. | Hawn SE et al. | β | 2019 | β |
| Interactive effects of genetic polymorphisms and childhood adversity on brain morphologic changes in depression. | Kim YK et al. | β | 2019 | β |
| Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight. | Qiu B et al. | β | 2019 | β |
| The clinical applications and practical relevance of human conditioning paradigms for posttraumatic stress disorder. | Zuj DV et al. | β | 2019 | β |
| Biological alterations affecting risk of adult psychopathology following childhood trauma: A review of sex differences. | Tiwari A et al. | β | 2018 | β |
| Can't get it out of my mind: A systematic review of predictors of intrusive memories of distressing events. | Marks EH et al. | β | 2018 | β |
| Childhood adversity as a transdiagnostic risk factor for affective disorders in adulthood: A systematic review focusing on biopsychosocial moderating and mediating variables. | Hoppen TH et al. | β | 2018 | β |
| Effects of repeated long-term psychosocial stress and acute cannabinoid exposure on mouse corticostriatal circuitries: Implications for neuropsychiatric disorders. | Tomas-Roig J et al. | β | 2018 | β |
| FKBP5 Moderates the Association between Antenatal Maternal Depressive Symptoms and Neonatal Brain Morphology. | Wang C et al. | β | 2018 | β |
| Hsp90 and FKBP51: complex regulators of psychiatric diseases. | Criado-Marrero M et al. | β | 2018 | β |
| Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric Disease. | Baker JD et al. | β | 2018 | β |
| Hypothalamic-pituitary-adrenal axis variants and childhood trauma influence anxiety sensitivity in South African adolescents. | Womersley JS et al. | β | 2018 | β |
| Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: A systematic review and meta-analysis. | Wang Q et al. | β | 2018 | β |
| Interaction between FKBP5 variability and recent life events in the anxiety spectrum: Evidence for the differential susceptibility model. | PΓ©rez-PΓ©rez B et al. | β | 2018 | β |
| Neurocognitive Endophenotypes of Schizophrenia and Bipolar Disorder and Possible Associations with FKBP Variant rs3800373. | Memic A et al. | β | 2018 | β |
| Neurogenetic Approaches to Stress and Fear in Humans as Pathophysiological Mechanisms for Posttraumatic Stress Disorder. | Nees F et al. | β | 2018 | β |
| Positive metacognitions about alcohol mediate the relationship between <i>FKBP5</i> variability and problematic drinking in a sample of young women. | Dragan WΕ et al. | β | 2018 | β |
| The BDNF Val66Met polymorphism moderates the relationship between Posttraumatic Stress Disorder and fear extinction learning. | Felmingham KL et al. | β | 2018 | β |
| Diverse structures, functions and uses of FK506 binding proteins. | Bonner JM et al. | β | 2017 | β |
| Dynamic expression of FKBP5 in the medial prefrontal cortex regulates resiliency to conditioned fear. | Criado-Marrero M et al. | β | 2017 | β |
| FKBP5 genotype and early life stress exposure predict neurobehavioral outcomes for preterm infants. | D'Agata AL et al. | β | 2017 | β |
| FKBP5 polymorphisms influence pre-learning stress-induced alterations of learning and memory. | Zoladz PR et al. | β | 2017 | β |
| From child maltreatment to emerging adult problem drinking: Identification of a multilevel internalizing pathway among African American youth. | Handley ED et al. | β | 2017 | β |
| Genetic approaches for the study of PTSD: Advances and challenges. | Banerjee SB et al. | β | 2017 | β |
| Molecular and Cellular Effects of Traumatic Stress: Implications for PTSD. | Girgenti MJ et al. | β | 2017 | β |
| Neurobiological Development in the Context of Childhood Trauma. | Cross D et al. | β | 2017 | β |
| Neuroinflammatory genes associated with post-traumatic stress disorder: implications for comorbidity. | Zass LJ et al. | β | 2017 | β |
| Pharmacogenetics and Pharmacotherapy of Military Personnel Suffering from Post-traumatic Stress Disorder. | NaΓ J et al. | β | 2017 | β |
| Single-nucleotide polymorphisms in genes related to the hypothalamic-pituitary-adrenal axis as risk factors for posttraumatic stress disorder. | Carvalho CM et al. | β | 2017 | β |
| The interactive effects of child maltreatment and the FK506 binding protein 5 gene (FKBP5) on dissociative symptoms in adolescence. | Yaylaci FT et al. | β | 2017 | β |
| Toward a unified theory of childhood trauma and psychosis: A comprehensive review of epidemiological, clinical, neuropsychological and biological findings. | Misiak B et al. | β | 2017 | β |
| When social support is not enough: Trauma and PTSD symptoms in a risk-sample of adolescents. | Pinto RJ et al. | β | 2017 | β |
| Association of FKBP5 polymorphisms and resting-state activity in a frontotemporal-parietal network. | Bryant RA et al. | β | 2016 | β |
| Associations between the FKBP5 haplotype, exposure to violence and anxiety in females. | Isaksson J et al. | β | 2016 | β |
| Associations of childhood adversity and adulthood trauma with C-reactive protein: A cross-sectional population-based study. | Lin JE et al. | β | 2016 | β |
| Biological underpinnings of trauma and post-traumatic stress disorder: focusing on genetics and epigenetics. | Ryan J et al. | β | 2016 | β |
| Dexamethasone Treatment Leads to Enhanced Fear Extinction and Dynamic Fkbp5 Regulation in Amygdala. | Sawamura T et al. | β | 2016 | β |
| FK506 binding protein 51 integrates pathways of adaptation: FKBP51 shapes the reactivity to environmental change. | Rein T | β | 2016 | β |
| FKBP5 genotype interacts with early life trauma to predict heavy drinking in college students. | Lieberman R et al. | β | 2016 | β |
| FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: Results from the National Health and Resilience in Veterans Study. | Watkins LE et al. | β | 2016 | β |
| FKBP5 polymorphisms moderate the influence of adverse life events on the risk of anxiety and depressive disorders in preschool children. | Scheuer S et al. | β | 2016 | β |
| Gene Γ Environment Determinants of Stress- and Anxiety-Related Disorders. | Sharma S et al. | β | 2016 | β |
| Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications. | Zannas AS et al. | β | 2016 | β |
| Genetics of glucocorticoid regulation and posttraumatic stress disorder--What do we know? | Castro-Vale I et al. | β | 2016 | β |
| Influence of interactions between genes and childhood trauma on refractoriness in psychiatric disorders. | Kim JS et al. | β | 2016 | β |
| Neuroimaging genetic approaches to Posttraumatic Stress Disorder. | Lebois LAM et al. | β | 2016 | β |
| Paradise Lost: The Neurobiological and Clinical Consequences of Child Abuse and Neglect. | Nemeroff CB | β | 2016 | β |
| RDoC and translational perspectives on the genetics of trauma-related psychiatric disorders. | Montalvo-Ortiz JL et al. | β | 2016 | β |
| Stress response genes and the severity of nicotine withdrawal. | Jensen KP et al. | β | 2016 | β |
| Systematic Review on Post-Traumatic Stress Disorder Among Survivors of the Wenchuan Earthquake. | Hong C et al. | β | 2016 | β |
| The centrality of fear extinction in linking risk factors to PTSD: A narrative review. | Zuj DV et al. | β | 2016 | β |
| The Effect of Nicotine on HPA Axis Activity in Females is Modulated by the FKBP5 Genotype. | Koopmann A et al. | β | 2016 | β |
| The FKBP5 Gene Affects Alcohol Drinking in Knockout Mice and Is Implicated in Alcohol Drinking in Humans. | Qiu B et al. | β | 2016 | β |
| The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders. | Smoller JW | β | 2016 | β |
| The role of hypothalamus-pituitary-adrenal genes and childhood trauma in borderline personality disorder. | MartΓn-Blanco A et al. | β | 2016 | β |
| Amygdala functional connectivity, HPA axis genetic variation, and life stress in children and relations to anxiety and emotion regulation. | Pagliaccio D et al. | β | 2015 | β |
| Biological correlates of complex posttraumatic stress disorder-state of research and future directions. | Marinova Z et al. | β | 2015 | β |
| Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes. | Chen L et al. | β | 2015 | β |
| Co-occurring tobacco use and posttraumatic stress disorder: Smoking cessation treatment implications. | Kelly MM et al. | β | 2015 | β |
| Cross-cultural gene- environment interactions in depression, post-traumatic stress disorder, and the cortisol awakening response: FKBP5 polymorphisms and childhood trauma in South Asia. | Kohrt BA et al. | β | 2015 | β |
| Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress. | Licznerski P et al. | β | 2015 | β |
| Developmental pathways from child maltreatment to adolescent marijuana dependence: Examining moderation by FK506 binding protein 5 gene (FKBP5). | Handley ED et al. | β | 2015 | β |
| Do common genotypes of FK506 binding protein 5 (FKBP5) moderate the effects of childhood maltreatment on cognition in schizophrenia and healthy controls? | Green MJ et al. | β | 2015 | β |
| Early adversity disrupts the adult use of aversive prediction errors to reduce fear in uncertainty. | Wright KM et al. | β | 2015 | β |
| Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder. | Kimbrel NA et al. | β | 2015 | β |
| Epigenetic Alterations Associated with War Trauma and Childhood Maltreatment. | Ramo-FernΓ‘ndez L et al. | β | 2015 | β |
| Epigenetics of Posttraumatic Stress Disorder: Current Evidence, Challenges, and Future Directions. | Zannas AS et al. | β | 2015 | β |
| FKBP5 risk alleles and the development of intrusive memories. | Cheung J et al. | β | 2015 | β |
| FKBP5 variation is associated with the acute and chronic effects of nicotine. | Jensen KP et al. | β | 2015 | β |
| Glucocorticoids, epigenetic control and stress resilience. | Reul JM et al. | β | 2015 | β |
| Life course epidemiology of trauma and related psychopathology in civilian populations. | Fink DS et al. | β | 2015 | β |
| Preclinical perspectives on posttraumatic stress disorder criteria in DSM-5. | Tye S et al. | β | 2015 | β |
| Psychiatric symptoms in adolescents: FKBP5 genotype--early life adversity interaction effects. | Comasco E et al. | β | 2015 | β |
| Schizophrenia in the spectrum of gene-stress interactions: the FKBP5 example. | Daskalakis NP et al. | β | 2015 | β |
| The Research Domain Criteria (RDoC) Project and Studies of Risk and Resilience in Maltreated Children. | Kaufman J et al. | β | 2015 | β |
| What can HPA axis-linked genes tell us about anxiety disorders in adolescents? | Bortoluzzi A et al. | β | 2015 | β |
| Combat exposure severity as a moderator of genetic and environmental liability to post-traumatic stress disorder. | Wolf EJ et al. | β | 2014 | β |
| Correcting systematic inflation in genetic association tests that consider interaction effects: application to a genome-wide association study of posttraumatic stress disorder. | Almli LM et al. | β | 2014 | β |
| Depletion of FKBP51 in female mice shapes HPA axis activity. | Hoeijmakers L et al. | β | 2014 | β |
| Drug addiction and stress-response genetic variability: association study in African Americans. | Levran O et al. | β | 2014 | β |
| Early intervention following trauma may mitigate genetic risk for PTSD in civilians: a pilot prospective emergency department study. | Rothbaum BO et al. | β | 2014 | β |
| Effect of the common functional FKBP5 variant (rs1360780) on the hypothalamic-pituitary-adrenal axis and peripheral blood gene expression. | Fujii T et al. | β | 2014 | β |
| Environmental stressors and epigenetic control of the hypothalamic-pituitary-adrenal axis. | Lee RS et al. | β | 2014 | β |
| [Expert testimony in post-traumatic stress disorder with pain as the main symptom]. | Egle UT et al. | β | 2014 | β |
| FKBP5 genotype and structural integrity of the posterior cingulum. | Fani N et al. | β | 2014 | β |
| FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls. | HΓΆhne N et al. | β | 2014 | β |
| FKBP5 moderates alcohol withdrawal severity: human genetic association and functional validation in knockout mice. | Huang MC et al. | β | 2014 | β |
| Framing ethnic variations in alcohol outcomes from biological pathways to neighborhood context. | Chartier KG et al. | β | 2014 | β |
| Gene-environment interaction. | Manuck SB et al. | β | 2014 | β |
| Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism. | Zannas AS et al. | β | 2014 | β |
| Gene-environment interactions in common mental disorders: an update and strategy for a genome-wide search. | Uher R | β | 2014 | β |
| Genetic approaches to understanding post-traumatic stress disorder. | Almli LM et al. | β | 2014 | β |
| Inflammation and psychopathology: what we now know, and what we need to know. | Uddin M et al. | β | 2014 | β |
| Interaction between genetic variants and exposure to Hurricane Katrina on post-traumatic stress and post-traumatic growth: a prospective analysis of low income adults. | Dunn EC et al. | β | 2014 | β |
| Interplay between diet-induced obesity and chronic stress in mice: potential role of FKBP51. | Balsevich G et al. | β | 2014 | β |
| Longitudinal epigenetic variation of DNA methyltransferase genes is associated with vulnerability to post-traumatic stress disorder. | Sipahi L et al. | β | 2014 | β |
| Moderating role of FKBP5 genotype in the impact of childhood adversity on cortisol stress response during adulthood. | Buchmann AF et al. | β | 2014 | β |
| Neurobehavioral Mechanisms of Traumatic Stress in Post-traumatic Stress Disorder. | Lapiz-Bluhm MD et al. | β | 2014 | β |
| No man is an island: living in a disadvantaged neighborhood influences chronic pain development after motor vehicle collision. | Ulirsch JC et al. | β | 2014 | β |
| Placental FKBP5 genetic and epigenetic variation is associated with infant neurobehavioral outcomes in the RICHS cohort. | Paquette AG et al. | β | 2014 | β |
| Progress towards understanding the genetics of posttraumatic stress disorder. | Voisey J et al. | β | 2014 | β |
| PTSD risk associated with a functional DRD2 polymorphism in heroin-dependent cases and controls is limited to amphetamine-dependent individuals. | Nelson EC et al. | β | 2014 | β |
| Stress-related genes and heroin addiction: a role for a functional FKBP5 haplotype. | Levran O et al. | β | 2014 | β |
| The biological effects of childhood trauma. | De Bellis MD et al. | β | 2014 | β |
| The prevalence and psychosocial correlates of suicide attempts among inpatient adolescent offspring of Croatian PTSD male war veterans. | BoriΔeviΔ MarΕ‘aniΔ V et al. | β | 2014 | β |
| The role of FKBP5 genotype in moderating long-term effectiveness of exposure-based psychotherapy for posttraumatic stress disorder. | Wilker S et al. | β | 2014 | β |
| Transcriptomic analysis of the effects of a fish oil enriched diet on murine brains. | Hammamieh R et al. | β | 2014 | β |
| A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia. | Zayats T et al. | β | 2013 | β |
| Adcyap1r1 genotype, posttraumatic stress disorder, and depression among women exposed to childhood maltreatment. | Uddin M et al. | β | 2013 | β |
| Allele-specific epigenetic modification: a molecular mechanism for gene-environment interactions in stress-related psychiatric disorders? | Klengel T et al. | β | 2013 | β |
| Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. | Klengel T et al. | β | 2013 | β |
| Association among clinical response, hippocampal volume, and FKBP5 gene expression in individuals with posttraumatic stress disorder receiving cognitive behavioral therapy. | Levy-Gigi E et al. | β | 2013 | β |
| Beyond risk, resilience, and dysregulation: phenotypic plasticity and human development. | Belsky J et al. | β | 2013 | β |
| Childhood maltreatment and psychopathology: A case for ecophenotypic variants as clinically and neurobiologically distinct subtypes. | Teicher MH et al. | β | 2013 | β |
| Childhood trauma as a cause of psychosis: linking genes, psychology, and biology. | van Winkel R et al. | β | 2013 | β |
| Considering trauma exposure in the context of genetics studies of posttraumatic stress disorder: a systematic review. | Digangi J et al. | β | 2013 | β |
| Disorders and borders: psychiatric genetics and nosology. | Smoller JW | β | 2013 | β |
| Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD. | Yehuda R et al. | β | 2013 | β |
| Exploring epigenetic regulation of fear memory and biomarkers associated with post-traumatic stress disorder. | Maddox SA et al. | β | 2013 | β |
| FKBP5 and attention bias for threat: associations with hippocampal function and shape. | Fani N et al. | β | 2013 | β |
| FKBP5 as a possible moderator of the psychosis-inducing effects of childhood trauma. | Collip D et al. | β | 2013 | β |
| Gene-environment interaction of ApoE genotype and combat exposure on PTSD. | Lyons MJ et al. | β | 2013 | β |
| Gene-environment interactions in major depressive disorder. | Klengel T et al. | β | 2013 | β |
| Gene Γ environment interactions in the prediction of response to antidepressant treatment. | Klengel T et al. | β | 2013 | β |
| Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults. | Mahon PB et al. | β | 2013 | β |
| Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression. | Menke A et al. | β | 2013 | β |
| Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder. | Xie P et al. | β | 2013 | β |
| Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner. | Bourke CH et al. | β | 2013 | β |
| Increased hippocampal volume and gene expression following cognitive behavioral therapy in PTSD. | Moustafa AA | β | 2013 | β |
| Interindividual Variability in Stress Susceptibility: A Role for Epigenetic Mechanisms in PTSD. | Zovkic IB et al. | β | 2013 | β |
| Polymorphisms in the glucocorticoid receptor co-chaperone FKBP5 predict persistent musculoskeletal pain after traumatic stress exposure. | Bortsov AV et al. | β | 2013 | β |
| Postpartum depression: psychoneuroimmunological underpinnings and treatment. | Anderson G et al. | β | 2013 | β |
| Predicting PTSD: pre-existing vulnerabilities in glucocorticoid-signaling and implications for preventive interventions. | van Zuiden M et al. | β | 2013 | β |
| Pretrauma risk factors for posttraumatic stress disorder: a systematic review of the literature. | DiGangi JA et al. | β | 2013 | β |
| Prevalence of bullying victimisation amongst first-episode psychosis patients and unaffected controls. | Trotta A et al. | β | 2013 | β |
| Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls. | Zhang H et al. | β | 2013 | β |
| Rethinking our public health genetics research paradigm. | El-Sayed AM et al. | β | 2013 | β |
| Role of allelic variants of FK506-binding protein 51 (FKBP5) gene in the development of anxiety disorders. | Minelli A et al. | β | 2013 | β |
| The association of a novel haplotype in the dopamine transporter with preschool age posttraumatic stress disorder. | Drury SS et al. | β | 2013 | β |
| The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance. | O'Leary JC et al. | β | 2013 | β |
| Translational reciprocity: bridging the gap between preclinical studies and clinical treatment of stress effects on the adolescent brain. | Neigh GN et al. | β | 2013 | β |
| A consideration of select pre-trauma factors as key vulnerabilities in PTSD. | Bomyea J et al. | β | 2012 | β |
| BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects. | Gerritsen L et al. | β | 2012 | β |
| Behavioral genetics of affective and anxiety disorders. | Domschke K et al. | β | 2012 | β |
| Consumer perspectives on genetic testing for psychiatric disorders: the attitudes of veterans with posttraumatic stress disorder and their families. | Dedert EA et al. | β | 2012 | β |
| Early interventions for PTSD: a review. | Kearns MC et al. | β | 2012 | β |
| FKBP5 and emotional neglect interact to predict individual differences in amygdala reactivity. | White MG et al. | β | 2012 | β |
| Gene-environment interaction in major depression and antidepressant treatment response. | Keers R et al. | β | 2012 | β |
| Gene Γ environment vulnerability factors for PTSD: the HPA-axis. | Mehta D et al. | β | 2012 | β |
| Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5. | Yang X et al. | β | 2012 | β |
| Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: a prospective study. | van Zuiden M et al. | β | 2012 | β |
| Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric research and treatment. | Boscarino JA et al. | β | 2012 | β |
| Joint Effect of Childhood Abuse and Family History of Major Depressive Disorder on Rates of PTSD in People with Personality Disorders. | Flory JD et al. | β | 2012 | β |
| Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans. | Han S et al. | β | 2012 | β |
| Physical health conditions associated with posttraumatic stress disorder in U.S. older adults: results from wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions. | Pietrzak RH et al. | β | 2012 | β |
| [Posttraumatic stress disorder (PTSD) as a consequence of the interaction between an individual genetic susceptibility, a traumatogenic event and a social context]. | AuxΓ©mΓ©ry Y | β | 2012 | β |
| PTSD and gene variants: new pathways and new thinking. | Skelton K et al. | β | 2012 | β |
| Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51. | Galigniana NM et al. | β | 2012 | β |
| Resilience and measured gene-environment interactions. | Kim-Cohen J et al. | β | 2012 | β |
| Serotonin transporter 5-HTTLPR genotype moderates the effects of childhood adversity on posttraumatic stress disorder risk: a replication study. | Xie P et al. | β | 2012 | β |
| Symptom persistence and memory performance in posttraumatic stress disorder: a gene x environment pilot stud. | David AC et al. | β | 2012 | β |
| The prospect of FKBP51 as a drug target. | Schmidt MV et al. | β | 2012 | β |
| The role of limbic system irritability in linking history of childhood maltreatment and psychiatric outcomes in low-income, high-risk women: moderation by FK506 binding protein 5 haplotype. | Dackis MN et al. | β | 2012 | β |
| A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51. | O'Leary JC et al. | β | 2011 | β |
| Cortisol suppression by dexamethasone reduces exaggerated fear responses in posttraumatic stress disorder. | Jovanovic T et al. | β | 2011 | β |
| Expression and regulation of the Fkbp5 gene in the adult mouse brain. | Scharf SH et al. | β | 2011 | β |
| FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. | Touma C et al. | β | 2011 | β |
| FKBP51 and FKBP52 in signaling and disease. | Storer CL et al. | β | 2011 | β |
| Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study. | Zimmermann P et al. | β | 2011 | β |
| Medical comorbidity of full and partial posttraumatic stress disorder in US adults: results from Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions. | Pietrzak RH et al. | β | 2011 | β |
| Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population. | Appel K et al. | β | 2011 | β |
| Psychiatry: A molecular shield from trauma. | Stein MB | β | 2011 | β |
| Relationship between FKBP5 polymorphisms and depression symptoms among kidney transplant recipients. | Shinozaki G et al. | β | 2011 | β |
| Serotonin transporter gene polymorphisms and brain function during emotional distraction from cognitive processing in posttraumatic stress disorder. | Morey RA et al. | β | 2011 | β |
| Stress modulation of cognitive and affective processes. | Campeau S et al. | β | 2011 | β |
| Using gene-environment interactions to target personalized treatment in mood disorder. | Klengel T et al. | β | 2011 | β |
| Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies. | Mehta D et al. | β | 2011 | β |
| FKBP5 polymorphisms modify the effects of childhood trauma. | Koenen KC et al. | β | 2010 | β |
| Genetics of post-traumatic stress disorder: review and recommendations for genome-wide association studies. | Cornelis MC et al. | β | 2010 | β |
| Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD. | Yehuda R et al. | β | 2010 | β |