PSEN1 gene
Evidence from:
primary |
all sources
Related entities (18)
| Subject | Relation | Object | p-value | Evidence |
|---|---|---|---|---|
| PSEN1 | associated_with | AD subjects | — | 1 |
| PSEN1 | associated_with | alcohol preference | — | 1 |
| PSEN1 | risk_factor_for | Alzheimer's disease | — | 2 |
| PSEN1 | risk_factor_for | Alzheimer’s disease | — | 1 |
| PSEN1 | associated_with | Aβ42/Aβ40 ratio | — | 1 |
| PSEN1 | regulates | CDH2 | — | 1 |
| PSEN1 | risk_factor_for | dementia | — | 1 |
| PSEN1 | risk_factor_for | Early-onset Alzheimer’s disease | — | 1 |
| PSEN1 | risk_factor_for | fAD | — | 1 |
| PSEN1 | risk_factor_for | neurodegeneration | — | 1 |
| PSEN1 | regulates | neurogenesis | — | 1 |
| PSEN1 | associated_with | neuronal loss | — | 1 |
| PSEN1 | regulates | Notch | — | 1 |
| PSEN1 | protective_against | plaque | — | 1 |
| PSEN1 | risk_factor_for | plaque | — | 1 |
| PSEN1 | regulates | proliferative cells | — | 1 |
| PSEN1 | regulates | Sdc3 | — | 1 |
| PSEN1 | regulates | γ-secretase | — | 1 |
Mentioned in (26)
Papers in which this entity is mentioned.
- Human 3D brain organoids: steering the demolecularization of brain and neurological diseases. (2023)
- Apolipoprotein E intersects with amyloid-β within neurons. (2023)
- Pitfalls of predicting age-related traits by polygenic risk scores. (2023)
- Epigenetics in Alzheimer's Disease. (2022)
- A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. (2021)
- Interpretation of risk loci from genome-wide association studies of Alzheimer's disease. (2020)
- Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice. (2017)
- ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease. (2017)
- Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations. (2017)
- Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells. (2016)
- Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes. (2016)
- Direct Transcriptional Effects of Apolipoprotein E. (2016)
- Evaluating historical candidate genes for schizophrenia. (2015)
- New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy. (2014)
- Physical exercise-induced adult neurogenesis: a good strategy to prevent cognitive decline in neurodegenerative diseases? (2014)
- In vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-β pathology. (2013)
- Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. (2012)
- A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories. (2011)
- Role of ubiquitin-proteasome-mediated proteolysis in nervous system disease. (2011)
- Apolipoprotein E: from lipid transport to neurobiology. (2011)
- Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging. (2011)
- Transgenic mouse models of Alzheimer's disease. (2010)
- Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease. (2009)
- Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. (2008)
- Network analysis of intrinsic functional brain connectivity in Alzheimer's disease. (2008)
- Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium. (2007)
Merged raw entities (6)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| psen1 | gene | 26 | 68 |
| psen1 mutation | variant | 2 | 2 |
| presenilin 1 | gene | 1 | 1 |
| presenilin-1 | gene | 1 | 1 |
| mutant psen1 | gene | — | — |
| psen1 mutation | gene | — | — |