DNA damage phenotype
Evidence from:
primary |
all sources
Related entities (5)
| Subject | Relation | Object | p-value | Evidence |
|---|---|---|---|---|
| acetaldehyde | risk_factor_for | DNA damage | — | 1 |
| aging | risk_factor_for | DNA damage | — | 1 |
| ALDH2 | protective_against | DNA damage | — | 1 |
| DNA damage | associated_with | TP53 | — | 1 |
| ethanol group | risk_factor_for | DNA damage | — | 1 |
Mentioned in (67)
Papers in which this entity is mentioned.
- Comprehensive repertoire of the chromosomal alteration and mutational signatures across 16 cancer types. (2026)
- FET fusion oncoproteins disrupt physiologic DNA repair and create a targetable opportunity for ATR inhibitor therapy. (2025)
- Multigenerational cell tracking of DNA replication and heritable DNA damage. (2025)
- Chromosomal instability as a driver of cancer progression. (2025)
- Transcription start sites experience a high influx of heritable variants fueled by early development. (2025)
- Gastrulation-stage alcohol exposure induces similar rates of craniofacial malformations in male and female C57BL/6J mice. (2024)
- ENPP1 Immunobiology as a Therapeutic Target. (2023)
- Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers. (2023)
- Towards understandings of serine/arginine-rich splicing factors. (2023)
- Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking. (2022)
- Transcriptomic analyses of gastrulation-stage mouse embryos with differential susceptibility to alcohol. (2021)
- Loss of tumor protein 53 protects against alcohol-induced facial malformations in mice and zebrafish. (2021)
- Macrophage Polarization States in the Tumor Microenvironment. (2021)
- Best practices for variant calling in clinical sequencing. (2020)
- DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers. (2020)
- Neonatal Alcohol Exposure in Mice Induces Select Differentiation- and Apoptosis-Related Chromatin Changes Both Independent of and Dependent on Sex. (2020)
- Emerging Roles of SRSF3 as a Therapeutic Target for Cancer. (2020)
- Modification of stem cell states by alcohol and acetaldehyde. (2020)
- Designing combination therapies with modeling chaperoned machine learning. (2019)
- RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues. (2019)
- A Compendium of Mutational Signatures of Environmental Agents. (2019)
- Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. (2018)
- The Cancer Spliceome: Reprograming of Alternative Splicing in Cancer. (2018)
- MutationalPatterns: comprehensive genome-wide analysis of mutational processes. (2018)
- EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma. (2018)
- HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. (2017)
- Gene-environment interactions in development and disease. (2017)
- Copy-number signatures and mutational processes in ovarian carcinoma (2017)
- Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin. (2016)
- New insights into the generation and role of de novo mutations in health and disease. (2016)
- Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors. (2016)
- Alteration of Gene Expression, DNA Methylation, and Histone Methylation in Free Radical Scavenging Networks in Adult Mouse Hippocampus following Fetal Alcohol Exposure. (2016)
- Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes. (2016)
- Oxidative stress signaling to chromatin in health and disease. (2016)
- Evolutionary Insights into RNA trans-Splicing in Vertebrates. (2016)
- The Genetics of Fetal Alcohol Spectrum Disorders. (2016)
- What is the DNA repair defect underlying Fanconi anemia? (2015)
- Post-translational modifications of histones that influence nucleosome dynamics. (2015)
- Spontaneous ATM Gene Reversion in A-T iPSC to Produce an Isogenic Cell Line. (2015)
- A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation. (2014)
- Break-induced replication is a source of mutation clusters underlying kataegis. (2014)
- Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. (2014)
- Gene-ethanol interactions underlying fetal alcohol spectrum disorders. (2014)
- Molecular pathways underpinning ethanol-induced neurodegeneration. (2014)
- Involvement of p53 in the repair of DNA double strand breaks: multifaceted Roles of p53 in homologous recombination repair (HRR) and non-homologous end joining (NHEJ). (2014)
- Ewing sarcoma protein: a key player in human cancer. (2013)
- RNA splicing: a new player in the DNA damage response. (2013)
- Associations between maternal genotypes and metabolites implicated in congenital heart defects. (2012)
- Mutational processes molding the genomes of 21 breast cancers. (2012)
- Detectable clonal mosaicism from birth to old age and its relationship to cancer. (2012)
- Massive genomic rearrangement acquired in a single catastrophic event during cancer development. (2011)
- BRCA1 and BRCA2: different roles in a common pathway of genome protection. (2011)
- Regulation of chromatin by histone modifications. (2011)
- Functional consequences of developmentally regulated alternative splicing. (2011)
- Molecular mechanisms of long noncoding RNAs. (2011)
- Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyces cerevisiae. (2011)
- Linking functional decline of telomeres, mitochondria and stem cells during ageing. (2010)
- Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells. (2010)
- Role of microglia in ethanol's apoptotic action on hypothalamic neuronal cells in primary cultures. (2010)
- The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles. (2009)
- Choline: an essential nutrient for public health. (2009)
- Neurotoxic effects and biomarkers of lead exposure: a review. (2009)
- Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF). (2009)
- 3' end mRNA processing: molecular mechanisms and implications for health and disease. (2008)
- MDM2 and MDM4: p53 regulators as targets in anticancer therapy. (2007)
- Maternal immune activation alters fetal brain development through interleukin-6. (2007)
- Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. (2005)
Merged raw entities (2)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| dna damage | phenotype | 67 | 138 |
| dna damage by aldehydes and alcohol | phenotype | — | — |