alternative splicing drug

Aliases: AS, PSI, alternative splicing events, percent spliced in
External links: DrugBank · PubChem

Evidence from: primary | all sources

Related entities (28)

Subject	Relation	Object	p-value	Evidence
African-Americans	associated_with	alternative splicing	—	1
age	associated_with	alternative splicing	—	1
alcohol	interacts_with	alternative splicing	—	1
alternative splicing	interacts_with	additive genetic influences	—	1
alternative splicing	associated_with	Alzheimer’s disease	—	1
alternative splicing	expressed_in	brain	—	1
alternative splicing	risk_factor_for	cannabis use	—	1
alternative splicing	associated_with	cigarettes	—	1
alternative splicing	associated_with	cocaine	—	1
alternative splicing	expressed_in	cortex	—	1
alternative splicing	associated_with	crack cocaine	—	1
alternative splicing	associated_with	drinks per week	—	1
alternative splicing	associated_with	hashish	—	1
alternative splicing	associated_with	heavy drinking	—	1
alternative splicing	associated_with	inhalants	—	1
alternative splicing	associated_with	marijuana	—	1
alternative splicing	associated_with	neuritic plaques	—	1
alternative splicing	associated_with	neurofibrillary tangles	—	1
alternative splicing	risk_factor_for	regular alcohol use	—	1
alternative splicing	risk_factor_for	regular smoking	—	1
alternative splicing	interacts_with	shared environmental influence	—	1
alternative splicing	associated_with	smokeless tobacco	—	1
alternative splicing	interacts_with	unique environmental influences	—	1
drug dependence	interacts_with	alternative splicing	—	1
peer substance use	associated_with	alternative splicing	—	1
shared environmental influence	associated_with	alternative splicing	—	1
Twin cohort	associated_with	alternative splicing	—	1
Twin cohort	expressed_in	alternative splicing	—	1

Mentioned in (37)

Papers in which this entity is mentioned.

Single-cell exon deletion profiling reveals splicing events that shape gene expression and cell state dynamics. (2026)
Single cell and spatial alternative splicing analysis with Nanopore long read sequencing. (2025)
Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy. (2024)
Global impact of unproductive splicing on human gene expression. (2024)
Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases. (2024)
ESPRESSO: Robust discovery and quantification of transcript isoforms from error-prone long-read RNA-seq data. (2023)
RNA splicing dysregulation and the hallmarks of cancer. (2023)
Application of third-generation sequencing in cancer research. (2021)
Alternative splicing: Human disease and quantitative analysis from high-throughput sequencing. (2021)
Transcriptomic signatures across human tissues identify functional rare genetic variation. (2020)
Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish. (2019)
The Cancer Spliceome: Reprograming of Alternative Splicing in Cancer. (2018)
Sequence, Structure, and Context Preferences of Human RNA Binding Proteins. (2018)
Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. (2018)
Annotation-free quantification of RNA splicing using LeafCutter. (2018)
Effects of selection for ethanol preference on gene expression in the nucleus accumbens of HS-CC mice. (2017)
Evolutionary Insights into RNA trans-Splicing in Vertebrates. (2016)
Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing. (2015)
RNA-binding protein RBM20 represses splicing to orchestrate cardiac pre-mRNA processing. (2014)
Transcriptome sequencing of a large human family identifies the impact of rare noncoding variants. (2014)
rMATS: robust and flexible detection of differential alternative splicing from replicate RNA-Seq data. (2014)
Exon identity crisis: disease-causing mutations that disrupt the splicing code. (2014)
RNA in unexpected places: long non-coding RNA functions in diverse cellular contexts. (2013)
Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges. (2013)
Ewing sarcoma protein: a key player in human cancer. (2013)
Gene expression in the human brain: the current state of the study of specificity and spatiotemporal dynamics. (2013)
RNA splicing: a new player in the DNA damage response. (2013)
Alt Event Finder: a tool for extracting alternative splicing events from RNA-seq data. (2012)
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. (2012)
Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. (2011)
Functional consequences of developmentally regulated alternative splicing. (2011)
Mechanisms and consequences of alternative polyadenylation. (2011)
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. (2011)
Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcripts. (2009)
An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. (2009)
Evolution of the neocortex: a perspective from developmental biology. (2009)
FASTSNP: an always up-to-date and extendable service for SNP function analysis and prioritization. (2006)

Merged raw entities (6)

All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.

Raw name	Type	Papers	Mentions
alternative splicing	phenotype	33	48
alternative splicing	drug	10	10
alternative splicing events	drug	—	—
as	drug	—	—
percent spliced in	drug	—	—
psi	drug	—	—