Dopamine D2 receptor drug

Aliases: D2, D2 receptor, D2R, DRD2
External links: DrugBank · PubChem

Evidence from: primary | all sources

Related entities (125)

Subject	Relation	Object	p-value	Evidence
alcohol	regulates	Dopamine D2 receptor	—	1
alcohol dependence	regulates	Dopamine D2 receptor	—	1
ANKK1	interacts_with	Dopamine D2 receptor	—	1
ANKK1	associated_with	Dopamine D2 receptor	—	2
antipsychotics	targets	Dopamine D2 receptor	—	3
CB1 receptor	interacts_with	Dopamine D2 receptor	—	1
c-fos	expressed_in	Dopamine D2 receptor	—	1
cigarettes	associated_with	Dopamine D2 receptor	—	1
cocaine	regulates	Dopamine D2 receptor	—	1
dopamine	interacts_with	Dopamine D2 receptor	—	2
Dopamine D2 receptor	associated_with	addiction	—	1
Dopamine D2 receptor	risk_factor_for	addiction	—	1
Dopamine D2 receptor	associated_with	addiction phenotypes	—	1
Dopamine D2 receptor	associated_with	ADHD	0.001	1
Dopamine D2 receptor	associated_with	adolescent alcohol use	—	1
Dopamine D2 receptor	targets	ALC	—	1
Dopamine D2 receptor	associated_with	alcohol dependence	—	1
Dopamine D2 receptor	risk_factor_for	alcohol dependence	—	3
Dopamine D2 receptor	risk_factor_for	alcoholism	—	1
Dopamine D2 receptor	associated_with	alcoholism	—	3
Dopamine D2 receptor	risk_factor_for	alcohol-related problems	—	1
Dopamine D2 receptor	biomarker_for	Alcohol Use Disorder	—	1
Dopamine D2 receptor	associated_with	Alcohol Use Disorder	—	1
Dopamine D2 receptor	associated_with	anhedonia	—	1
Dopamine D2 receptor	interacts_with	antipsychotics	—	1
Dopamine D2 receptor	associated_with	associated SNPs	—	1
Dopamine D2 receptor	risk_factor_for	AUD	—	1
Dopamine D2 receptor	associated_with	AUDIT	—	1
Dopamine D2 receptor	biomarker_for	AUDIT	—	1
Dopamine D2 receptor	associated_with	auditory	—	1
Dopamine D2 receptor	risk_factor_for	auditory	—	1
Dopamine D2 receptor	risk_factor_for	borderline personality disorder	—	1
Dopamine D2 receptor	expressed_in	brain	—	1
Dopamine D2 receptor	expressed_in	brain tissue	—	1
Dopamine D2 receptor	expressed_in	caudate nucleus	—	2
Dopamine D2 receptor	expressed_in	CeA	—	1
Dopamine D2 receptor	expressed_in	cerebellar hemisphere	—	1
Dopamine D2 receptor	expressed_in	CNS	—	1
Dopamine D2 receptor	associated_with	cocaine	—	2
Dopamine D2 receptor	biomarker_for	cocaine	—	2
Dopamine D2 receptor	associated_with	consumption	—	1
Dopamine D2 receptor	risk_factor_for	delay discounting	—	1
Dopamine D2 receptor	associated_with	depression	—	1
Dopamine D2 receptor	associated_with	disinhibition	—	1
Dopamine D2 receptor	regulates	dopamine	—	1
Dopamine D2 receptor	regulates	Dopaminergic system	—	1
Dopamine D2 receptor	expressed_in	dorsal striatum	—	1
Dopamine D2 receptor	interacts_with	dorsolateral prefrontal cortex	—	1
Dopamine D2 receptor	interacts_with	DRD4	0.01	1
Dopamine D2 receptor	associated_with	drinking	—	1
Dopamine D2 receptor	associated_with	drug dependence	—	1
Dopamine D2 receptor	interacts_with	drugs	—	1
Dopamine D2 receptor	protective_against	drug-seeking behavior	—	1
Dopamine D2 receptor	interacts_with	ethanol group	—	1
Dopamine D2 receptor	regulates	ethanol preference	—	1
Dopamine D2 receptor	associated_with	heavy drinking	—	1
Dopamine D2 receptor	risk_factor_for	human alcoholics	—	1
Dopamine D2 receptor	expressed_in	hypothalamus	—	1
Dopamine D2 receptor	risk_factor_for	impulsive phenotype	—	1
Dopamine D2 receptor	associated_with	impulsivity	—	3
Dopamine D2 receptor	risk_factor_for	impulsivity	—	1
Dopamine D2 receptor	associated_with	major depressive disorder	—	1
Dopamine D2 receptor	expressed_in	medium spiny neuron	—	1
Dopamine D2 receptor	expressed_in	medium spiny neurons	—	2
Dopamine D2 receptor	interacts_with	morphine	—	1
Dopamine D2 receptor	interacts_with	naloxone	—	1
Dopamine D2 receptor	interacts_with	NCS1	—	1
Dopamine D2 receptor	associated_with	nicotine	—	1
Dopamine D2 receptor	risk_factor_for	nicotine	—	2
Dopamine D2 receptor	risk_factor_for	nicotine addiction	—	1
Dopamine D2 receptor	associated_with	novelty seeking	—	2
Dopamine D2 receptor	expressed_in	nucleus accumbens	1.87e-20	3
Dopamine D2 receptor	expressed_in	nucleus accumbens shell	—	1
Dopamine D2 receptor	associated_with	obesity	—	1
Dopamine D2 receptor	risk_factor_for	opioid dependence	—	1
Dopamine D2 receptor	risk_factor_for	pair bonding	—	1
Dopamine D2 receptor	risk_factor_for	PAU	—	2
Dopamine D2 receptor	biomarker_for	PAU	—	1
Dopamine D2 receptor	associated_with	PAU	2.64e-06	2
Dopamine D2 receptor	regulates	PKC	—	1
Dopamine D2 receptor	associated_with	Post-Traumatic Stress Disorder	—	2
Dopamine D2 receptor	expressed_in	prefrontal cortex	—	2
Dopamine D2 receptor	associated_with	problems	—	1
Dopamine D2 receptor	expressed_in	putamen	—	1
Dopamine D2 receptor	associated_with	reinforcement learning	—	1
Dopamine D2 receptor	associated_with	response inhibition	—	1
Dopamine D2 receptor	biomarker_for	reversal learning	—	1
Dopamine D2 receptor	risk_factor_for	schizophrenia	—	1
Dopamine D2 receptor	associated_with	schizophrenia	—	2
Dopamine D2 receptor	associated_with	smoking	—	2
Dopamine D2 receptor	associated_with	smoking behaviour	—	1
Dopamine D2 receptor	biomarker_for	smoking cessation	—	1
Dopamine D2 receptor	expressed_in	striatum	—	10
Dopamine D2 receptor	risk_factor_for	substance abuse	—	1
Dopamine D2 receptor	associated_with	substance abuse	—	1
Dopamine D2 receptor	risk_factor_for	substance use	—	3
Dopamine D2 receptor	associated_with	TS	—	1
Dopamine D2 receptor	associated_with	UKB	—	1
Dopamine D2 receptor	biomarker_for	UKB	—	1
Dopamine D2 receptor	expressed_in	ventral striatum	—	1
Dopamine D2 receptor	expressed_in	VS	—	1
Dopamine D2 receptor	regulates	working memory	—	1
Dopamine D2 receptor	interacts_with	Δ9-THC	—	1
DRD1	interacts_with	Dopamine D2 receptor	—	1
DRD4 VNTR	interacts_with	Dopamine D2 receptor	—	1
drug dependence	regulates	Dopamine D2 receptor	—	1
ethanol consumption	regulates	Dopamine D2 receptor	—	1
ethanol group	regulates	Dopamine D2 receptor	—	2
NCS1	regulates	Dopamine D2 receptor	—	1
NCS1	interacts_with	Dopamine D2 receptor	—	1
nicotine	targets	Dopamine D2 receptor	—	1
Oxytocin receptor	regulates	Dopamine D2 receptor	—	1
Oxytocin receptor	interacts_with	Dopamine D2 receptor	—	1
PKC	regulates	Dopamine D2 receptor	—	1
Prenatal nicotine exposure	regulates	Dopamine D2 receptor	—	1
rs1076560	regulates	Dopamine D2 receptor	—	2
rs1076560	associated_with	Dopamine D2 receptor	—	1
rs1800497	associated_with	Dopamine D2 receptor	—	2
rs1800497	regulates	Dopamine D2 receptor	—	1
rs2283265	associated_with	Dopamine D2 receptor	—	1
rs2283265	regulates	Dopamine D2 receptor	—	1
sex	interacts_with	Dopamine D2 receptor	—	1
TAC3	interacts_with	Dopamine D2 receptor	—	1
Taq1A allele	associated_with	Dopamine D2 receptor	—	1
Val158Met	interacts_with	Dopamine D2 receptor	—	1

Mentioned in (17)

Papers in which this entity is mentioned.

The role of oxytocin in alcohol and drug abuse. (2020)
TGF-β/Smad3 Signalling Modulates GABA Neurotransmission: Implications in Parkinson's Disease. (2020)
mTORC2 in the dorsomedial striatum of mice contributes to alcohol-dependent F-Actin polymerization, structural modifications, and consumption. (2018)
Effect of Neuroinflammation on Synaptic Organization and Function in the Developing Brain: Implications for Neurodevelopmental and Neurodegenerative Disorders. (2017)
CB1 cannabinoid receptor-mediated increases in cyclic AMP accumulation are correlated with reduced Gi/o function. (2016)
Common liability to addiction and "gateway hypothesis": theoretical, empirical and evolutionary perspective. (2012)
The neural effects of psychotropic medications in children and adolescents. (2012)
Cholinergic modulation of synaptic integration and dendritic excitability in the striatum. (2011)
Developmental trajectories during adolescence in males and females: a cross-species understanding of underlying brain changes. (2011)
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. (2011)
AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. (2011)
Adolescent development of the reward system. (2010)
Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition. (2010)
Protein kinases and addiction. (2008)
fMRI reveals alteration of spatial working memory networks across adolescence. (2005)
In utero cocaine-induced dysfunction of dopamine D1 receptor signaling and abnormal differentiation of cerebral cortical neurons. (2000)
Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor. (1997)

Merged raw entities (6)

All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.

Raw name	Type	Papers	Mentions
d2 receptor	drug	10	16
dopamine d2 receptor	drug	6	7
dopamine d2 receptor	gene	2	2
d2	drug	—	—
d2r	drug	—	—
drd2	drug	—	—