apoE4 gene
Evidence from:
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Related entities (25)
| Subject | Relation | Object | p-value | Evidence |
|---|---|---|---|---|
| apoE4 | risk_factor_for | Alzheimer's disease | — | 1 |
| apoE4 | regulates | Amyloid beta | — | 1 |
| apoE4 | risk_factor_for | Amyloid beta | — | 1 |
| apoE4 | associated_with | Amyloid beta | — | 1 |
| apoE4 | associated_with | apoE | — | 1 |
| apoE4 | regulates | APP | — | 1 |
| apoE4 | associated_with | axonal degeneration | — | 1 |
| apoE4 | regulates | Aβ production | — | 1 |
| apoE4 | risk_factor_for | brain | — | 1 |
| apoE4 | expressed_in | brain | — | 1 |
| apoE4 | regulates | Caspase-3 | — | 1 |
| apoE4 | expressed_in | cerebrospinal fluid | — | 1 |
| apoE4 | expressed_in | endoplasmic reticulum | — | 1 |
| apoE4 | expressed_in | GABA | — | 1 |
| apoE4 | risk_factor_for | GABA | — | 1 |
| apoE4 | regulates | GABA | — | 1 |
| apoE4 | expressed_in | hiPSC-derived neurons | — | 1 |
| apoE4 | expressed_in | knock-in mice | — | 1 |
| apoE4 | regulates | phosphorylated tau | — | 1 |
| apoE4 | associated_with | p-tau | — | 1 |
| apoE4 | risk_factor_for | p-tau | — | 1 |
| apoE4 | regulates | p-tau | — | 1 |
| apoE4 | associated_with | tau pathology | — | 1 |
| apoE4 | regulates | tau phosphorylation | — | 1 |
| apoE4 | expressed_in | transgenic mice | — | 1 |
Mentioned in (25)
Papers in which this entity is mentioned.
- Human 3D brain organoids: steering the demolecularization of brain and neurological diseases. (2023)
- Apolipoprotein E intersects with amyloid-β within neurons. (2023)
- Large-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity. (2021)
- Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration. (2021)
- Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease. (2021)
- Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity. (2020)
- Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. (2018)
- ApoE Regulates the Development of Adult Newborn Hippocampal Neurons. (2018)
- ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease. (2017)
- The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease. (2017)
- Gray matter maturation and cognition in children with different APOE ε genotypes. (2016)
- Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice. (2016)
- Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation. (2016)
- Direct Transcriptional Effects of Apolipoprotein E. (2016)
- An introductory review of parallel independent component analysis (p-ICA) and a guide to applying p-ICA to genetic data and imaging phenotypes to identify disease-associated biological pathways and systems in common complex disorders. (2015)
- The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. (2014)
- ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice. (2013)
- Bridging animal and human models of exercise-induced brain plasticity. (2013)
- In vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-β pathology. (2013)
- Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator-activated receptor-γ agonists. (2011)
- Apolipoprotein E: from lipid transport to neurobiology. (2011)
- Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. (2010)
- Obesity is linked with lower brain volume in 700 AD and MCI patients. (2010)
- COG1410, an apolipoprotein E-based peptide, improves cognitive performance and reduces cortical loss following moderate fluid percussion injury in the rat. (2010)
- Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain. (2001)
Merged raw entities (4)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| apoe4 | variant | 24 | 301 |
| apoe4 | gene | 3 | 8 |
| apoe4/4 genotype | gene | — | — |
| apolipoprotein e epsilon 4 allele | gene | — | — |