choline drug
Evidence from:
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all sources
Related entities (11)
| Subject | Relation | Object | p-value | Evidence |
|---|---|---|---|---|
| choline | protective_against | Fetal Alcohol Spectrum Disorder | — | 1 |
| choline | expressed_in | gray matter | — | 1 |
| choline | biomarker_for | hepatic encephalopathy | — | 1 |
| choline | regulates | hippocampus | — | 1 |
| choline | protective_against | memory | — | 1 |
| choline | associated_with | normal aging | — | 1 |
| choline | regulates | prefrontal cortex | — | 1 |
| choline | expressed_in | thalamus | — | 1 |
| choline | biomarker_for | Wernicke's encephalopathy | — | 1 |
| choline | expressed_in | white matter | — | 2 |
| thiamine | regulates | choline | — | 1 |
Mentioned in (177)
Papers in which this entity is mentioned.
- Regional cerebellum volume anomalies and associated cognitive function in children with fetal alcohol spectrum disorders. (2026)
- Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure. (2025)
- Alcohol Exposure May Increase Prenatal Choline Needs Through Redirection of Choline into Lipid Synthesis Rather than Methyl Donation. (2025)
- Predicting fetal alcohol spectrum disorders in preschool-aged children from early life factors. (2024)
- Evidence and Perspectives for Choline Supplementation during Parenteral Nutrition-A Narrative Review. (2024)
- Oral supplementation of choline attenuates the development of alcohol-related liver disease (ALD). (2024)
- Early moderate prenatal alcohol exposure and maternal diet impact offspring DNA methylation across species. (2024)
- Choline-An Underappreciated Component of a Mother-to-Be's Diet. (2024)
- A Narrative Review on Maternal Choline Intake and Liver Function of the Fetus and the Infant; Implications for Research, Policy, and Practice. (2024)
- The ameliorative effects of choline on ethanol-induced cell death in the neural tube of susceptible BXD strains of mice. (2023)
- Neurodevelopment among children exposed to HIV and uninfected in sub-Saharan Africa. (2023)
- Alcohol blunts pregnancy-mediated insulin resistance and reduces fetal brain glucose despite elevated fetal gluconeogenesis, and these changes associate with fetal weight outcomes. (2023)
- Current considerations for fetal alcohol spectrum disorders: identification to intervention. (2023)
- The effects of gestational choline supplementation on cerebellar Purkinje cell number in the sheep model of binge alcohol exposure during the first trimester-equivalent. (2022)
- Untargeted Metabolome Analysis of Alcohol-Exposed Pregnancies Reveals Metabolite Differences That Are Associated with Infant Birth Outcomes. (2022)
- Untargeted Metabolome Analysis Reveals Reductions in Maternal Hepatic Glucose and Amino Acid Content That Correlate with Fetal Organ Weights in a Mouse Model of Fetal Alcohol Spectrum Disorders. (2022)
- The impact of micronutrient supplementation in alcohol-exposed pregnancies on reaction time responses of preschoolers in Ukraine. (2022)
- Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes. (2022)
- Fetal Alcohol Spectrum Disorders: Awareness to Insight in Just 50 Years. (2022)
- Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies. (2022)
- Beneficial Effects of Betaine: A Comprehensive Review. (2021)
- Prenatal choline supplementation during mouse pregnancy has differential effects in alcohol-exposed fetal organs. (2021)
- Partner influence as a factor in maternal alcohol consumption and depressive symptoms, and maternal effects on infant neurodevelopmental outcomes. (2021)
- Maternal choline supplementation mitigates alcohol exposure effects on neonatal brain volumes. (2021)
- Early-life nicotine or cotinine exposure produces long-lasting sleep alterations and downregulation of hippocampal corticosteroid receptors in adult mice. (2021)
- Executive and Social Functioning Across Development in Children and Adolescents With Prenatal Alcohol Exposure. (2021)
- Choline Kinase: An Unexpected Journey for a Precision Medicine Strategy in Human Diseases. (2021)
- Measurement of neurodevelopmental effects of prenatal alcohol exposure in Ukrainian preschool children. (2021)
- Choline metabolome response to prenatal choline supplementation across pregnancy: A randomized controlled trial. (2021)
- Multifactorial Genetic and Environmental Hedgehog Pathway Disruption Sensitizes Embryos to Alcohol-Induced Craniofacial Defects. (2020)
- Alterations in the whole brain network organization after prenatal ethanol exposure. (2020)
- Altered Maternal Plasma Fatty Acid Composition by Alcohol Consumption and Smoking during Pregnancy and Associations with Fetal Alcohol Spectrum Disorders. (2020)
- Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days. (2020)
- Murine Models for the Study of Fetal Alcohol Spectrum Disorders: An Overview. (2020)
- Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder. (2020)
- Prenatal Developmental Origins of Future Psychopathology: Mechanisms and Pathways. (2019)
- Functional Connectivity and Metabolic Alterations in Medial Prefrontal Cortex in a Rat Model of Fetal Alcohol Spectrum Disorder: A Resting-State Functional Magnetic Resonance Imaging and in vivo Proton Magnetic Resonance Spectroscopy Study. (2019)
- Gestational age and socioeconomic status as mediators for the impact of prenatal alcohol exposure on development at 6 months. (2019)
- Clinical presentation, diagnosis, and management of fetal alcohol spectrum disorder. (2019)
- Maternal choline supplementation mitigates alcohol-induced fetal cranio-facial abnormalities detected using an ultrasonographic examination in a sheep model. (2019)
- Challenges in pediatric neuroimaging. (2019)
- Persistent Changes in Stress-Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol. (2019)
- Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. (2018)
- Imaging of Concussion in Young Athletes. (2018)
- Epigenetic mechanisms in alcohol- and adversity-induced developmental origins of neurobehavioral functioning. (2018)
- Effects of prenatal alcohol exposure (PAE): insights into FASD using mouse models of PAE. (2018)
- Implications of altered maternal cytokine concentrations on infant outcomes in children with prenatal alcohol exposure. (2018)
- Perinatal HIV Infection or Exposure Is Associated With Low -Acetylaspartate and Glutamate in Basal Ganglia at Age 9 but Not 7 Years. (2018)
- Altered brain morphometry in 7-year old HIV-infected children on early ART. (2018)
- Vitamin D Deficiency in Pregnant Ukrainian Women: Effects of Alcohol Consumption on Vitamin D Status. (2017)
- One-Carbon Metabolism in Health and Disease. (2017)
- Maternal choline supplementation during murine pregnancy modulates placental markers of inflammation, apoptosis and vascularization in a fetal sex-dependent manner. (2017)
- Facial Curvature Detects and Explicates Ethnic Differences in Effects of Prenatal Alcohol Exposure. (2017)
- Alcohol's Effects on the Brain: Neuroimaging Results in Humans and Animal Models. (2017)
- Postnatal choline supplementation selectively attenuates hippocampal microRNA alterations associated with developmental alcohol exposure. (2017)
- Epigenetics studies of fetal alcohol spectrum disorder: where are we now? (2017)
- Choline and Working Memory Training Improve Cognitive Deficits Caused by Prenatal Exposure to Ethanol. (2017)
- Usual Choline Intakes Are Associated with Egg and Protein Food Consumption in the United States. (2017)
- Dietary choline levels modify the effects of prenatal alcohol exposure in rats. (2017)
- Maternal choline supplementation in a sheep model of first trimester binge alcohol fails to protect against brain volume reductions in peripubertal lambs. (2016)
- Maternal nutritional status as a contributing factor for the risk of fetal alcohol spectrum disorders. (2016)
- Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. (2016)
- Assessing the Independent and Joint Effects of Unmedicated Prenatal Depressive Symptoms and Alcohol Consumption in Pregnancy and Infant Neurodevelopmental Outcomes. (2016)
- Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis. (2016)
- Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR(mt). (2016)
- Randomized, double-blind, placebo-controlled clinical trial of choline supplementation in school-aged children with fetal alcohol spectrum disorders. (2016)
- The Placenta as a Mediator of Stress Effects on Neurodevelopmental Reprogramming. (2016)
- Maternal dietary intake of choline in mice regulates development of the cerebral cortex in the offspring. (2016)
- Dietary Nutrient Intake in School-Aged Children With Heavy Prenatal Alcohol Exposure. (2016)
- Antenatal depression, treatment with selective serotonin reuptake inhibitors, and neonatal brain structure: A propensity-matched cohort study. (2016)
- Increasing the GluN2A/GluN2B Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace. (2016)
- Cardiac Orienting Responses Differentiate the Impact of Prenatal Alcohol Exposure in Ukrainian Toddlers. (2016)
- Adolescent Choline Supplementation Attenuates Working Memory Deficits in Rats Exposed to Alcohol During the Third Trimester Equivalent. (2016)
- Effects of Ethanol on the Cerebellum: Advances and Prospects. (2015)
- Eyeblink Classical Conditioning in Alcoholism and Fetal Alcohol Spectrum Disorders. (2015)
- Dose and Timing of Prenatal Alcohol Exposure and Maternal Nutritional Supplements: Developmental Effects on 6-Month-Old Infants. (2015)
- The impact of micronutrient supplementation in alcohol-exposed pregnancies on information processing skills in Ukrainian infants. (2015)
- Formate metabolism in fetal and neonatal sheep. (2015)
- Zebrafish retinal defects induced by ethanol exposure are rescued by retinoic acid and folic acid supplement. (2015)
- Advances in Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: From Animal Models to Human Studies. (2015)
- Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial. (2015)
- Inappropriate feeding behaviors and dietary intakes in children with fetal alcohol spectrum disorder or probable prenatal alcohol exposure. (2014)
- An in vivo 1H magnetic resonance spectroscopy study of the deep cerebellar nuclei in children with fetal alcohol spectrum disorders. (2014)
- A comparison of spectral quality in magnetic resonance spectroscopy data acquired with and without a novel EPI-navigated PRESS sequence in school-aged children with fetal alcohol spectrum disorders. (2014)
- The Effects of Arsenic Exposure on Neurological and Cognitive Dysfunction in Human and Rodent Studies: A Review. (2014)
- Quality of 186 child brain spectra using motion and B0 shim navigated single voxel spectroscopy. (2014)
- Dietary intake, nutrition, and fetal alcohol spectrum disorders in the Western Cape Province of South Africa. (2014)
- Supplemental choline does not attenuate the effects of neonatal ethanol administration on habituation of the heart rate orienting response in rats. (2014)
- Exercise and environment as an intervention for neonatal alcohol effects on hippocampal adult neurogenesis and learning. (2014)
- Genetic influences on brain developmental trajectories on neuroimaging studies: from infancy to young adulthood. (2014)
- The impact of environmental factors in severe psychiatric disorders. (2014)
- Fetal alcohol spectrum disorders and their transmission through genetic and epigenetic mechanisms. (2014)
- Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice. (2014)
- Development of thalamocortical connectivity during infancy and its cognitive correlations. (2014)
- Choline partially prevents the impact of ethanol on the lipid raft dependent functions of l1 cell adhesion molecule. (2014)
- Gestational choline supplementation normalized fetal alcohol-induced alterations in histone modifications, DNA methylation, and proopiomelanocortin (POMC) gene expression in β-endorphin-producing POMC neurons of the hypothalamus. (2013)
- Inadequate intake of nutrients essential for neurodevelopment in children with fetal alcohol spectrum disorders (FASD). (2013)
- Nutrition in pregnancy: the argument for including a source of choline. (2013)
- Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice. (2013)
- Associations between multivitamin supplement use and alcohol consumption before pregnancy: Pregnancy Risk Assessment Monitoring System, 2004 to 2008. (2013)
- The role of nutrition in children's neurocognitive development, from pregnancy through childhood. (2013)
- Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women. (2013)
- DNA methylation program in developing hippocampus and its alteration by alcohol. (2013)
- Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. (2013)
- Fetal alcohol-related growth restriction from birth through young adulthood and moderating effects of maternal prepregnancy weight. (2013)
- Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study. (2013)
- Choline intake during pregnancy and child cognition at age 7 years. (2013)
- Epigenetic medicine and fetal alcohol spectrum disorders. (2013)
- Neuroprotective actions of perinatal choline nutrition. (2013)
- Alcohol exposure during development: Impact on the epigenome. (2013)
- Choline supplementation mitigates trace, but not delay, eyeblink conditioning deficits in rats exposed to alcohol during development. (2012)
- Adequacy of maternal iron status protects against behavioral, neuroanatomical, and growth deficits in fetal alcohol spectrum disorders. (2012)
- Early second trimester maternal plasma choline and betaine are related to measures of early cognitive development in term infants. (2012)
- Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial. (2012)
- Maternal intake of methyl-donor nutrients and child cognition at 3 years of age. (2012)
- Choline supplementation and DNA methylation in the hippocampus and prefrontal cortex of rats exposed to alcohol during development. (2012)
- The effects of perinatal choline supplementation on hippocampal cholinergic development in rats exposed to alcohol during the brain growth spurt. (2012)
- The neural effects of psychotropic medications in children and adolescents. (2012)
- Maternal nutritional status, C(1) metabolism and offspring DNA methylation: a review of current evidence in human subjects. (2012)
- Fetal alcohol spectrum disorders: experimental treatments and strategies for intervention. (2011)
- Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction. (2011)
- Fetal alcohol spectrum disorders: research challenges and opportunities. (2011)
- What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders. (2011)
- Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood. (2011)
- Magnetic resonance-based imaging in animal models of fetal alcohol spectrum disorder. (2011)
- Subtle decreases in DNA methylation and gene expression at the mouse Igf2 locus following prenatal alcohol exposure: effects of a methyl-supplemented diet. (2011)
- Fetal alcohol spectrum disorders and abnormal neuronal plasticity. (2011)
- Maternal risk factors for fetal alcohol spectrum disorders: not as simple as it might seem. (2011)
- Focus on: magnetic resonance-based studies of fetal alcohol spectrum disorders in animal models. (2011)
- Focus on: epigenetics and fetal alcohol spectrum disorders. (2011)
- Focus on: structural and functional brain abnormalities in fetal alcohol spectrum disorders. (2011)
- Does lack of multinutrient supplementation during early pregnancy increase vulnerability to alcohol-related preterm or small-for-gestational-age births? (2011)
- Focus on: the use of animal models for the study of fetal alcohol spectrum disorders. (2011)
- Contributions of studies on alcohol use disorders to understanding cerebellar function. (2010)
- Normal development of brain circuits. (2010)
- Short echo time proton magnetic resonance spectroscopy in Alzheimer's disease: a longitudinal multiple time point study. (2010)
- Fetal alcohol spectrum disorders: from research to policy. (2010)
- Cingulate gyrus morphology in children and adolescents with fetal alcohol spectrum disorders. (2010)
- Prospective motion correction for single-voxel 1H MR spectroscopy. (2010)
- Prenatal alcohol exposure triggers ceramide-induced apoptosis in neural crest-derived tissues concurrent with defective cranial development. (2010)
- Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats. (2010)
- In vivo magnetic resonance spectroscopy: basic methodology and clinical applications. (2010)
- Structural, metabolic, and functional brain abnormalities as a result of prenatal exposure to drugs of abuse: evidence from neuroimaging. (2010)
- The plausibility of maternal nutritional status being a contributing factor to the risk for fetal alcohol spectrum disorders: the potential influence of zinc status as an example. (2010)
- Prenatal choline supplementation mitigates the adverse effects of prenatal alcohol exposure on development in rats. (2009)
- Choline: an essential nutrient for public health. (2009)
- Magnetic resonance spectroscopy outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders. (2009)
- Altered neurometabolites and motor integration in children exposed to methamphetamine in utero. (2009)
- Functional magnetic resonance imaging outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders. (2009)
- Neuroimaging of children following prenatal drug exposure. (2009)
- Animal models of fetal alcohol spectrum disorders: impact of the social environment. (2009)
- Neuroimaging of children following prenatal drug exposure. (2009)
- Magnetic resonance imaging outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders. (2009)
- Neuropyschological and behavioral outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders. (2009)
- Characterization of white matter microstructure in fetal alcohol spectrum disorders. (2009)
- Protein kinases and addiction. (2008)
- Choline supplementation attenuates learning deficits associated with neonatal alcohol exposure in the rat: effects of varying the timing of choline administration. (2008)
- Choline concentrations in human maternal and cord blood and intelligence at 5 y of age. (2008)
- Neuroimaging studies of normal brain development and their relevance for understanding childhood neuropsychiatric disorders. (2008)
- Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats. (2008)
- Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. (2007)
- Prenatal choline availability modulates hippocampal neurogenesis and neurogenic responses to enriching experiences in adult female rats. (2007)
- Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains. (2006)
- Choline: critical role during fetal development and dietary requirements in adults. (2006)
- Common genetic polymorphisms affect the human requirement for the nutrient choline. (2006)
- Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. (2006)
- Perinatal choline influences brain structure and function. (2006)
- The fetal origins of memory: the role of dietary choline in optimal brain development. (2006)
- alpha7 Nicotinic acetylcholine receptors and temporal memory: synergistic effects of combining prenatal choline and nicotine on reinforcement-induced resetting of an interval clock. (2006)
- Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans. (2005)
- Dietary intake of choline and plasma choline concentrations in pregnant women in Jamaica. (2005)
- Maternal dietary choline availability alters the balance of netrin-1 and DCC neuronal migration proteins in fetal mouse brain hippocampus. (2005)
- C-reactive protein: a critical update. (2003)
- Transposable elements: targets for early nutritional effects on epigenetic gene regulation. (2003)
- Prenatal choline supplementation protects against postnatal neurotoxicity. (2002)
- Coupled and uncoupled proton movement by amino acid transport system N. (2001)
- Protective effects of prenatal choline supplementation on seizure-induced memory impairment. (2000)
Merged raw entities (6)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| choline | drug | 173 | 1676 |
| phosphocholine | drug | 18 | 43 |
| glycerophosphocholine | drug | 10 | 18 |
| free choline | drug | 9 | 15 |
| choline-containing compounds | drug | 5 | 6 |
| methyl-donor choline | drug | — | — |