APP gene
Evidence from:
primary |
all sources
Related entities (35)
Mentioned in (55)
Papers in which this entity is mentioned.
- Human 3D brain organoids: steering the demolecularization of brain and neurological diseases. (2023)
- Apolipoprotein E intersects with amyloid-β within neurons. (2023)
- Pitfalls of predicting age-related traits by polygenic risk scores. (2023)
- Epigenetics in Alzheimer's Disease. (2022)
- A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. (2021)
- Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration. (2021)
- Interpretation of risk loci from genome-wide association studies of Alzheimer's disease. (2020)
- HSP70 and HSP90 in neurodegenerative diseases. (2020)
- Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. (2018)
- Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex. (2018)
- Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. (2018)
- Human Brain Abnormalities Associated With Prenatal Alcohol Exposure and Fetal Alcohol Spectrum Disorder. (2017)
- Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome. (2017)
- ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease. (2017)
- Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations. (2017)
- Nuclear organization and 3D chromatin architecture in cognition and neuropsychiatric disorders. (2016)
- Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells. (2016)
- Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes. (2016)
- Direct Transcriptional Effects of Apolipoprotein E. (2016)
- Low Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell Function. (2016)
- CTCF as a multifunctional protein in genome regulation and gene expression. (2015)
- A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis. (2015)
- Evaluating historical candidate genes for schizophrenia. (2015)
- The Effects of Arsenic Exposure on Neurological and Cognitive Dysfunction in Human and Rodent Studies: A Review. (2014)
- Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. (2014)
- Heritability and genomics of gene expression in peripheral blood. (2014)
- New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy. (2014)
- Physical exercise-induced adult neurogenesis: a good strategy to prevent cognitive decline in neurodegenerative diseases? (2014)
- Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure. (2013)
- ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice. (2013)
- Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice. (2013)
- In vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-β pathology. (2013)
- Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. (2012)
- Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. (2012)
- DISC1 at 10: connecting psychiatric genetics and neuroscience. (2011)
- Role of ubiquitin-proteasome-mediated proteolysis in nervous system disease. (2011)
- The role of DYRK1A in neurodegenerative diseases. (2011)
- Down syndrome: searching for the genetic culprits. (2011)
- Apolipoprotein E: from lipid transport to neurobiology. (2011)
- S100B and APP promote a gliocentric shift and impaired neurogenesis in Down syndrome neural progenitors. (2011)
- Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging. (2011)
- Transgenic mouse models of Alzheimer's disease. (2010)
- Integrative analysis of the melanoma transcriptome. (2010)
- Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. (2010)
- Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells. (2010)
- Down syndrome--recent progress and future prospects. (2009)
- Neurotoxic effects and biomarkers of lead exposure: a review. (2009)
- Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease. (2009)
- The power of comparative and developmental studies for mouse models of Down syndrome. (2007)
- Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. (2007)
- Origin of oligodendrocytes in the subventricular zone of the adult brain. (2006)
- COGA phenotypes and linkages on chromosome 2. (2005)
- Relationship between availability of NMDA receptor subunits and their expression at the synapse. (2002)
- Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain. (2001)
- Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse. (2000)
Merged raw entities (5)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| app | gene | 53 | 261 |
| amyloid precursor protein | gene | 6 | 6 |
| aβ precursor protein | gene | — | — |
| human app | gene | — | — |
| soluble app | gene | — | — |