PI3K gene
Evidence from:
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all sources
Related entities (9)
| Subject | Relation | Object | p-value | Evidence |
|---|---|---|---|---|
| ERBB4 | interacts_with | PI3K | — | 1 |
| LY294002 | targets | PI3K | — | 2 |
| LY294002 | regulates | PI3K | — | 1 |
| LY294002 | interacts_with | PI3K | — | 1 |
| PI3K | regulates | Akt | — | 1 |
| PI3K | interacts_with | AKT1 | — | 1 |
| PI3K | risk_factor_for | schizophrenia | — | 1 |
| Ras | regulates | PI3K | — | 1 |
| serotonin | regulates | PI3K | — | 1 |
Mentioned in (72)
Papers in which this entity is mentioned.
- Nanopore-based cell-free DNA fragmentation and methylation profiles from the cerebral spinal fluid of patients with lung cancer brain metastases. (2025)
- The landscape of drug sensitivity and resistance in sarcoma. (2024)
- Osteoclasts in Osteosarcoma: Mechanisms, Interactions, and Therapeutic Prospects. (2023)
- Alcohol blunts pregnancy-mediated insulin resistance and reduces fetal brain glucose despite elevated fetal gluconeogenesis, and these changes associate with fetal weight outcomes. (2023)
- Explainable multiview framework for dissecting spatial relationships from highly multiplexed data. (2022)
- Loss of tumor protein 53 protects against alcohol-induced facial malformations in mice and zebrafish. (2021)
- Choline Kinase: An Unexpected Journey for a Precision Medicine Strategy in Human Diseases. (2021)
- Macrophage Polarization States in the Tumor Microenvironment. (2021)
- Immuno-genomic landscape of osteosarcoma. (2020)
- Murine Models for the Study of Fetal Alcohol Spectrum Disorders: An Overview. (2020)
- Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors. (2020)
- Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group. (2019)
- Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy. (2019)
- Clinical presentation, diagnosis, and management of fetal alcohol spectrum disorder. (2019)
- Prenatal Environment That Affects Neuronal Migration. (2019)
- Pan-cancer whole-genome analyses of metastatic solid tumours. (2019)
- Detection of Somatic Structural Variants Enables Quantification and Characterization of Circulating Tumor DNA in Children With Solid Tumors. (2018)
- PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions. (2018)
- Diving into the world of alcohol teratogenesis: a review of zebrafish models of fetal alcohol spectrum disorder. (2018)
- Copy number signatures and mutational processes in ovarian carcinoma. (2018)
- Demystifying the cytokine network: Mathematical models point the way. (2017)
- OncoKB: A Precision Oncology Knowledge Base. (2017)
- Patient-derived xenografts undergo mouse-specific tumor evolution. (2017)
- Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors. (2017)
- Gene-environment interactions in development and disease. (2017)
- A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. (2017)
- ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease. (2017)
- Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma. (2017)
- Interaction of glycosphingolipids GD3 and GD2 with growth factor receptors maintains breast cancer stem cell phenotype. (2017)
- Copy-number signatures and mutational processes in ovarian carcinoma (2017)
- Pdgfra and Pdgfrb genetically interact during craniofacial development. (2016)
- Development and clinical application of an integrative genomic approach to personalized cancer therapy. (2016)
- Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia. (2016)
- The Genetics of Fetal Alcohol Spectrum Disorders. (2016)
- Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. (2016)
- Recent genetic findings in schizophrenia and their therapeutic relevance. (2015)
- Integrative clinical genomics of advanced prostate cancer. (2015)
- Regulation of mTORC1 by PI3K signaling. (2015)
- Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance. (2015)
- Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies. (2014)
- SRF regulates craniofacial development through selective recruitment of MRTF cofactors by PDGF signaling. (2014)
- The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease. (2014)
- Gene-ethanol interactions underlying fetal alcohol spectrum disorders. (2014)
- Cancer genome landscapes. (2013)
- A critical role for PDGFRα signaling in medial nasal process development. (2013)
- Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD. (2013)
- Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas. (2013)
- Emerging landscape of oncogenic signatures across human cancers. (2013)
- Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. (2013)
- The genomic landscape of hypodiploid acute lymphoblastic leukemia. (2013)
- Growth cone travel in space and time: the cellular ensemble of cytoskeleton, adhesion, and membrane. (2012)
- Patient-derived tumour xenografts as models for oncology drug development. (2012)
- Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging. (2011)
- Phosphatidylinositol 3-kinase/protein kinase Cdelta activation induces close homolog of adhesion molecule L1 (CHL1) expression in cultured astrocytes. (2010)
- PDGF function in diverse neural crest cell populations. (2010)
- Linking functional decline of telomeres, mitochondria and stem cells during ageing. (2010)
- Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation. (2010)
- Cellular metabolic stress: considering how cells respond to nutrient excess. (2010)
- Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation. (2009)
- Effects of ethanol and ipsapirone on the expression of genes encoding anti-apoptotic proteins and an antioxidant enzyme in ethanol-treated neurons. (2009)
- Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. (2008)
- Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling. (2008)
- Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. (2008)
- The role of cytoplasmic serine residues of the cell adhesion molecule L1 in neurite outgrowth, endocytosis, and cell migration. (2007)
- Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity. (2005)
- Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes. (2004)
- Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms. (2003)
- Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development. (2003)
- Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner. (2001)
- Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways. (2000)
- Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis. (1995)
- Transient IGF-I gene expression during the maturation of functionally related central projection neurons. (1991)
Merged raw entities (6)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| pi3k | gene | 59 | 137 |
| pi3k | drug | 35 | 81 |
| phosphatidylinositol 3-kinase | gene | 1 | 1 |
| phosphoinositide 3-kinase | gene | 1 | 1 |
| p100δ isoform of catalytic subunit of pi3k | gene | — | — |
| pi(3)k | gene | — | — |