DNA drug

Aliases

DNA, DNA (>1000 bps), DNA molecules, DNA samples, DNA sequence, Genomic DNA, deoxyribonucleic acid, double-stranded DNA, dsDNA, genomic DNA, high molecular weight DNA, immunoprecipitated DNA, input DNA, saliva DNA sample

External links

DrugBank · PubChem

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Mentioned in (177)

Papers in which this entity is mentioned.

• Integrative epigenetics and transcriptomics identify aging genes in human blood. (2026)
• Genome modelling and design across all domains of life with Evo 2. (2026)
• A guide to transcriptomic deconvolution in cancer. (2026)
• Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models. (2026)
• Whole-genome landscapes of 1,364 breast cancers. (2026)
• LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development. (2025)
• Annotating the genome at single-nucleotide resolution with DNA foundation models. (2025)
• Enhancer activation from transposable elements in extrachromosomal DNA. (2025)
• Stratified Medicine Pediatrics: Cell-Free DNA and Serial Tumor Sequencing Identifies Subtype-Specific Cancer Evolution and Epigenetic States. (2025)
• Connectome-seq: High-throughput Mapping of Neuronal Connectivity at Single-Synapse Resolution via Barcode Sequencing. (2025)
• ChromoGen: Diffusion model predicts single-cell chromatin conformations. (2025)
• Rapid brain tumor classification from sparse epigenomic data. (2025)
• Microfluidic purification of genomic DNA. (2025)
• Chromosomal instability as a driver of cancer progression. (2025)
• Efficient and accurate search in petabase-scale sequence repositories. (2025)
• Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders. (2025)
• Functional analysis of cancer-associated germline risk variants. (2025)
• Three-dimensional genome landscape of primary human cancers. (2025)
• Single cell and spatial alternative splicing analysis with Nanopore long read sequencing. (2025)
• Nucleotide Transformer: building and evaluating robust foundation models for human genomics. (2025)
• Alcohol Exposure May Increase Prenatal Choline Needs Through Redirection of Choline into Lipid Synthesis Rather than Methyl Donation. (2025)
• Foundation models in bioinformatics. (2025)
• Transcription start sites experience a high influx of heritable variants fueled by early development. (2025)
• DNA breathing integration with deep learning foundational model advances genome-wide binding prediction of human transcription factors. (2024)
• Yield of genetic association signals from genomes, exomes and imputation in the UK Biobank. (2024)
• Sequence modeling and design from molecular to genome scale with Evo. (2024)
• Transient loss of Polycomb components induces an epigenetic cancer fate. (2024)
• Alternative splicing of transcript mediates the response of circadian clocks to temperature changes. (2024)
• Nanopore sequencing with unique molecular identifiers enables accurate mutation analysis and haplotyping in the complex lipoprotein(a) KIV-2 VNTR. (2024)
• Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology. (2024)
• The Application of Long-Read Sequencing to Cancer. (2024)
• ENPP1 Immunobiology as a Therapeutic Target. (2023)
• Cell-Free DNA Fragmentomics: The Novel Promising Biomarker. (2023)
• A DNA methylation atlas of normal human cell types. (2023)
• Single-molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing. (2023)
• GenSLMs: Genome-scale language models reveal SARS-CoV-2 evolutionary dynamics. (2022)
• At the dawn: cell-free DNA fragmentomics and gene regulation. (2022)
• Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking. (2022)
• Epigenetic analysis of cell-free DNA by fragmentomic profiling. (2022)
• Nanopore sequencing of RNA and cDNA molecules in . (2022)
• Human Retrotransposons and Effective Computational Detection Methods for Next-Generation Sequencing Data. (2022)
• Massively parallel reporter perturbation assays uncover temporal regulatory architecture during neural differentiation. (2022)
• Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression. (2022)
• Sequence aligners can guarantee accuracy in almost <i>O</i> ( <i>m</i> log <i>n</i> ) time: a rigorous average-case analysis of the seed-chain-extend heuristic (2022)
• Inferring gene expression from cell-free DNA fragmentation profiles. (2022)
• Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers. (2022)
• Nanopore sequencing technology, bioinformatics and applications. (2021)
• Integrated Genomic Analysis Identifies Driver Genes and Cisplatin-Resistant Progenitor Phenotype in Pediatric Liver Cancer. (2021)
• Application of third-generation sequencing in cancer research. (2021)
• A practical guide to cancer subclonal reconstruction from DNA sequencing. (2021)
• A Comprehensive Circulating Tumor DNA Assay for Detection of Translocation and Copy-Number Changes in Pediatric Sarcomas. (2021)
• Whole-genome analysis reveals the contribution of non-coding de novo transposon insertions to autism spectrum disorder. (2021)
• Accurate detection of circulating tumor DNA using nanopore consensus sequencing. (2021)
• Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes. (2021)
• NUP98-NSD1 Driven MDS/MPN in Childhood Masquerading as JMML. (2021)
• Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X. (2020)
• Structural variation in the sequencing era. (2020)
• UMI-linked consensus sequencing enables phylogenetic analysis of directed evolution. (2020)
• Inferring structural variant cancer cell fraction. (2020)
• Nanopore sequencing and the Shasta toolkit enable efficient de novo assembly of eleven human genomes. (2020)
• AmpliconReconstructor integrates NGS and optical mapping to resolve the complex structures of focal amplifications. (2020)
• FQSqueezer: k-mer-based compression of sequencing data. (2020)
• Comprehensive analysis of structural variants in breast cancer genomes using single-molecule sequencing. (2020)
• Establishing guidelines to harmonize tumor mutational burden (TMB): in silico assessment of variation in TMB quantification across diagnostic platforms: phase I of the Friends of Cancer Research TMB Harmonization Project. (2020)
• Data structures based on <i>k</i> -mers for querying large collections of sequencing datasets (2019)
• Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity. (2019)
• Polygenic prediction via Bayesian regression and continuous shrinkage priors. (2019)
• Hypermethylation of Proopiomelanocortin and Period 2 Genes in Blood Are Associated with Greater Subjective and Behavioral Motivation for Alcohol in Humans. (2019)
• Ploidy- and Purity-Adjusted Allele-Specific DNA Analysis Using CLONETv2. (2019)
• Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. (2019)
• Whole-genome sequencing of triple-negative breast cancers in a population-based clinical study. (2019)
• CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis. (2019)
• Genome-Informed Targeted Therapy for Osteosarcoma. (2019)
• Genome-wide cell-free DNA fragmentation in patients with cancer. (2019)
• RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues. (2019)
• Persistent Changes in Stress-Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol. (2019)
• Best practices for bioinformatic characterization of neoantigens for clinical utility. (2019)
• Pan-cancer whole-genome analyses of metastatic solid tumours. (2019)
• Circular DNA elements of chromosomal origin are common in healthy human somatic tissue. (2018)
• A SNP panel for identification of DNA and RNA specimens. (2018)
• Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours. (2018)
• Quantification of subclonal selection in cancer from bulk sequencing data. (2018)
• The Human Transcription Factors. (2018)
• The Immune Landscape of Cancer. (2018)
• Nanopore sequencing and assembly of a human genome with ultra-long reads. (2018)
• Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome. (2018)
• Molecular profiling and sequential somatic mutation shift in hypermutator tumours harbouring POLE mutations. (2018)
• PDGFRA gene, maternal binge drinking and obstructive heart defects. (2018)
• Picky comprehensively detects high-resolution structural variants in nanopore long reads. (2018)
• Nanopore Sequencing Reveals High-Resolution Structural Variation in the Cancer Genome (2017)
• GAVIN: Gene-Aware Variant INterpretation for medical sequencing. (2017)
• HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. (2017)
• Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. (2017)
• A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies. (2017)
• Patient-derived xenografts undergo mouse-specific tumor evolution. (2017)
• The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies. (2017)
• GRIDSS: sensitive and specific genomic rearrangement detection using positional de Bruijn graph assembly. (2017)
• Who's Who? Detecting and Resolving Sample Anomalies in Human DNA Sequencing Studies with Peddy. (2017)
• Mapping and phasing of structural variation in patient genomes using nanopore sequencing. (2017)
• A method to reduce ancestry related germline false positives in tumor only somatic variant calling. (2017)
• Epigenetics studies of fetal alcohol spectrum disorder: where are we now? (2017)
• ReMixT: clone-specific genomic structure estimation in cancer. (2017)
• Copy-number signatures and mutational processes in ovarian carcinoma (2017)
• Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. (2017)
• An open access pilot freely sharing cancer genomic data from participants in Texas. (2016)
• Statistical modeling for sensitive detection of low-frequency single nucleotide variants. (2016)
• New insights into the generation and role of de novo mutations in health and disease. (2016)
• Integrated digital error suppression for improved detection of circulating tumor DNA. (2016)
• GeneiASE: Detection of condition-dependent and static allele-specific expression from RNA-seq data without haplotype information. (2016)
• Somatic cancer variant curation and harmonization through consensus minimum variant level data. (2016)
• Fragment Length of Circulating Tumor DNA. (2016)
• Global analysis of somatic structural genomic alterations and their impact on gene expression in diverse human cancers. (2016)
• Landscape of somatic mutations in 560 breast cancer whole-genome sequences. (2016)
• Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. (2016)
• A genomic case study of desmoplastic small round cell tumor: comprehensive analysis reveals insights into potential therapeutic targets and development of a monitoring tool for a rare and aggressive disease. (2016)
• Three decades of nanopore sequencing. (2016)
• Parasail: SIMD C library for global, semi-global, and local pairwise sequence alignments. (2016)
• Development and clinical application of an integrative genomic approach to personalized cancer therapy. (2016)
• Tools and best practices for data processing in allelic expression analysis. (2015)
• EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions. (2015)
• Sequenza: allele-specific copy number and mutation profiles from tumor sequencing data. (2015)
• Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia. (2015)
• ENVE: a novel computational framework characterizes copy-number mutational landscapes in colorectal cancers from African American patients. (2015)
• Spatial reconstruction of single-cell gene expression data. (2015)
• Systematic pan-cancer analysis of tumour purity. (2015)
• Comprehensive genomic profiles of small cell lung cancer. (2015)
• MBASED: allele-specific expression detection in cancer tissues and cell lines. (2014)
• RADIA: RNA and DNA integrated analysis for somatic mutation detection. (2014)
• MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens. (2014)
• Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine. (2014)
• Inference of high resolution HLA types using genome-wide RNA or DNA sequencing reads. (2014)
• Clonal evolution in hematological malignancies and therapeutic implications. (2014)
• Diminishing return for increased Mappability with longer sequencing reads: implications of the k-mer distributions in the human genome. (2014)
• PyClone: statistical inference of clonal population structure in cancer. (2014)
• Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer. (2013)
• Cancer genome landscapes. (2013)
• THetA: inferring intra-tumor heterogeneity from high-throughput DNA sequencing data. (2013)
• Ewing sarcoma protein: a key player in human cancer. (2013)
• A simple consensus approach improves somatic mutation prediction accuracy. (2013)
• Rapid genome mapping in nanochannel arrays for highly complete and accurate de novo sequence assembly of the complex Aegilops tauschii genome. (2013)
• ACMG clinical laboratory standards for next-generation sequencing. (2013)
• Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. (2013)
• Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. (2013)
• The genomic landscape of hypodiploid acute lymphoblastic leukemia. (2013)
• The Genotype-Tissue Expression (GTEx) project. (2013)
• Characterizing and measuring bias in sequence data. (2013)
• ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia. (2012)
• Absolute quantification of somatic DNA alterations in human cancer. (2012)
• An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia. (2012)
• Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions. (2012)
• The future of DNA sequence archiving. (2012)
• A cross-sample statistical model for SNP detection in short-read sequencing data. (2012)
• Ultrasensitive detection of rare mutations using next-generation targeted resequencing. (2012)
• Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations. (2012)
• The Pediatric Cancer Genome Project. (2012)
• Summarizing and correcting the GC content bias in high-throughput sequencing. (2012)
• HLA typing from RNA-Seq sequence reads. (2012)
• Massive genomic rearrangement acquired in a single catastrophic event during cancer development. (2011)
• BRCA1 and BRCA2: different roles in a common pathway of genome protection. (2011)
• Effects of ethanol and NAP on cerebellar expression of the neural cell adhesion molecule L1. (2011)
• Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion. (2011)
• ViennaRNA Package 2.0. (2011)
• An integrated ChIP-seq analysis platform with customizable workflows. (2011)
• Allele-specific copy number analysis of tumors. (2010)
• DNA copy number, including telomeres and mitochondria, assayed using next-generation sequencing. (2010)
• Rapid, low-input, low-bias construction of shotgun fragment libraries by high-density in vitro transposition. (2010)
• The Sanger FASTQ file format for sequences with quality scores, and the Solexa/Illumina FASTQ variants. (2010)
• BreakDancer: an algorithm for high-resolution mapping of genomic structural variation. (2009)
• Genomic copy number determination in cancer cells from single nucleotide polymorphism microarrays based on quantitative genotyping corrected for aneuploidy. (2009)
• Recurring mutations found by sequencing an acute myeloid leukemia genome. (2009)
• High-resolution mapping of copy-number alterations with massively parallel sequencing. (2009)
• Copy-number-variation and copy-number-alteration region detection by cumulative plots. (2009)
• Computation for ChIP-seq and RNA-seq studies. (2009)
• Rapid SNP discovery and genetic mapping using sequenced RAD markers. (2008)
• Accurate and reliable high-throughput detection of copy number variation in the human genome. (2006)
• Taverna: a tool for building and running workflows of services. (2006)
• Rapid Sex Determination Using PCR Technique Compared to Classic Cytogenetics - PMC

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