EDTA drug

Aliases

1 mM EDTA, ethylenediaminetetraacetic acid

External links

DrugBank · PubChem

Related entities (8)

Mentioned in (179)

Papers in which this entity is mentioned.

• Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models. (2026)
• Single-cell exon deletion profiling reveals splicing events that shape gene expression and cell state dynamics. (2026)
• LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development. (2025)
• Nanopore-based cell-free DNA fragmentation and methylation profiles from the cerebral spinal fluid of patients with lung cancer brain metastases. (2025)
• Tumour-wide RNA splicing aberrations generate actionable public neoantigens. (2025)
• Rapid brain tumor classification from sparse epigenomic data. (2025)
• Microfluidic purification of genomic DNA. (2025)
• Single cell and spatial alternative splicing analysis with Nanopore long read sequencing. (2025)
• Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders. (2024)
• Global impact of unproductive splicing on human gene expression. (2024)
• Machine-guided design of cell-type-targeting cis-regulatory elements. (2024)
• Sequence modeling and design from molecular to genome scale with Evo. (2024)
• Detection and analysis of complex structural variation in human genomes across populations and in brains of donors with psychiatric disorders. (2024)
• Combined low-pass whole genome and targeted sequencing in liquid biopsies for pediatric solid tumors. (2023)
• Alcohol blunts pregnancy-mediated insulin resistance and reduces fetal brain glucose despite elevated fetal gluconeogenesis, and these changes associate with fetal weight outcomes. (2023)
• Single-molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing. (2023)
• Nanopore sequencing of RNA and cDNA molecules in . (2022)
• Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids. (2022)
• GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate. (2022)
• Activation of the anterior cingulate cortex ameliorates anxiety in a preclinical model of fetal alcohol spectrum disorders. (2022)
• Circulating Tumor DNA Is Associated with Response and Survival in Patients with Advanced Leiomyosarcoma. (2022)
• Integrated analysis of multimodal single-cell data. (2021)
• Integrated Genomic Analysis Identifies Driver Genes and Cisplatin-Resistant Progenitor Phenotype in Pediatric Liver Cancer. (2021)
• Joint single-cell measurements of nuclear proteins and RNA in vivo. (2021)
• Detection and characterization of lung cancer using cell-free DNA fragmentomes. (2021)
• Infant circulating MicroRNAs as biomarkers of effect in fetal alcohol spectrum disorders. (2021)
• Accurate detection of circulating tumor DNA using nanopore consensus sequencing. (2021)
• Simultaneous single cell measurements of intranuclear proteins and gene expression (2021)
• Choline metabolome response to prenatal choline supplementation across pregnancy: A randomized controlled trial. (2021)
• Simultaneous epigenetic perturbation and genome imaging reveal distinct roles of H3K9me3 in chromatin architecture and transcription. (2020)
• Immune network dysregulation associated with child neurodevelopmental delay: modulatory role of prenatal alcohol exposure. (2020)
• Altered Maternal Plasma Fatty Acid Composition by Alcohol Consumption and Smoking during Pregnancy and Associations with Fetal Alcohol Spectrum Disorders. (2020)
• Nanopore sequencing and the Shasta toolkit enable efficient de novo assembly of eleven human genomes. (2020)
• Folding Keratin Gene Clusters during Skin Regional Specification. (2020)
• An interaction between fetal sex and placental weight and efficiency predicts intrauterine growth in response to maternal protein insufficiency and gestational exposure window in a mouse model of FASD. (2020)
• PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome. (2020)
• Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity. (2019)
• Cannabinoids Exacerbate Alcohol Teratogenesis by a CB1-Hedgehog Interaction. (2019)
• Genetic compensation triggered by mutant mRNA degradation. (2019)
• Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. (2019)
• Effects of nicotine exposure on murine mandibular development. (2019)
• Programmed increases in LXRα induced by paternal alcohol use enhance offspring metabolic adaptation to high-fat diet induced obesity. (2019)
• Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways. (2019)
• Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells. (2019)
• CUT&RUNTools: a flexible pipeline for CUT&RUN processing and footprint analysis. (2019)
• RNA-Seq Signatures Normalized by mRNA Abundance Allow Absolute Deconvolution of Human Immune Cell Types. (2019)
• Genome-wide cell-free DNA fragmentation in patients with cancer. (2019)
• Persistent Changes in Stress-Regulatory Genes in Pregnant Women or Children Exposed Prenatally to Alcohol. (2019)
• A Compendium of Mutational Signatures of Environmental Agents. (2019)
• Alcohol metabolism contributes to brain histone acetylation. (2019)
• Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. (2018)
• Sequence, Structure, and Context Preferences of Human RNA Binding Proteins. (2018)
• Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmission. (2018)
• Implications of altered maternal cytokine concentrations on infant outcomes in children with prenatal alcohol exposure. (2018)
• Oxytocin Receptor Gene Variant Interacts with Intervention Delivery Format in Predicting Intervention Outcomes for Youth with Conduct Problems. (2018)
• Positively selected enhancer elements endow osteosarcoma cells with metastatic competence. (2018)
• Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex. (2018)
• Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain. (2018)
• Nanopore sequencing and assembly of a human genome with ultra-long reads. (2018)
• Tumor fraction in cell-free DNA as a biomarker in prostate cancer. (2018)
• Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication. (2018)
• EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma. (2018)
• Vitamin D Deficiency in Pregnant Ukrainian Women: Effects of Alcohol Consumption on Vitamin D Status. (2017)
• An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues. (2017)
• The acute effect of cannabis on plasma, liver and brain ammonia dynamics, a translational study. (2017)
• Maternal choline supplementation during murine pregnancy modulates placental markers of inflammation, apoptosis and vascularization in a fetal sex-dependent manner. (2017)
• Assembly of functionally integrated human forebrain spheroids. (2017)
• A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. (2017)
• Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome. (2017)
• Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice. (2017)
• Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain. (2017)
• Ethanol itself is a holoprosencephaly-inducing teratogen. (2017)
• Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors. (2017)
• Impact of cytosine methylation on DNA binding specificities of human transcription factors. (2017)
• PGBD5 promotes site-specific oncogenic mutations in human tumors. (2017)
• Single-Cell Profiling of an In Vitro Model of Human Interneuron Development Reveals Temporal Dynamics of Cell Type Production and Maturation. (2017)
• Comprehensive Analysis of Hypermutation in Human Cancer. (2017)
• Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. (2017)
• Evidence for an immune signature of prenatal alcohol exposure in female rats. (2016)
• Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium. (2016)
• Musculocontractural Ehlers-Danlos syndrome and neurocristopathies: dermatan sulfate is required for Xenopus neural crest cells to migrate and adhere to fibronectin. (2016)
• Inhibition of Mammary Cancer Progression in Fetal Alcohol Exposed Rats by β-Endorphin Neurons. (2016)
• Fragment Length of Circulating Tumor DNA. (2016)
• Sustained synchronized neuronal network activity in a human astrocyte co-culture system. (2016)
• Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR(mt). (2016)
• Alteration of Gene Expression, DNA Methylation, and Histone Methylation in Free Radical Scavenging Networks in Adult Mouse Hippocampus following Fetal Alcohol Exposure. (2016)
• Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. (2016)
• Comprehensive analyses of tumor immunity: implications for cancer immunotherapy. (2016)
• Development and clinical application of an integrative genomic approach to personalized cancer therapy. (2016)
• Increasing the GluN2A/GluN2B Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace. (2016)
• Direct Transcriptional Effects of Apolipoprotein E. (2016)
• Prenatal Alcohol Exposure and Pair Feeding Differentially Impact Puberty and Reproductive Development in Female Rats: Role of the Kisspeptin System. (2016)
• Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors. (2015)
• EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions. (2015)
• Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects. (2015)
• A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis. (2015)
• Spatial reconstruction of single-cell gene expression data. (2015)
• Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood. (2015)
• Prenatal arsenic exposure alters the programming of the glucocorticoid signaling system during embryonic development. (2015)
• BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells. (2015)
• Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats. (2015)
• CtBP2 is an independent prognostic marker that promotes GLI1 induced epithelial-mesenchymal transition in hepatocellular carcinoma. (2015)
• RNA imaging. Spatially resolved, highly multiplexed RNA profiling in single cells. (2015)
• A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation. (2014)
• Condensins are Required for Maintenance of Nuclear Architecture. (2014)
• Effect of lipid raft disruption on ethanol inhibition of l1 adhesion. (2014)
• Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain. (2014)
• Maternal and neonatal plasma microRNA biomarkers for fetal alcohol exposure in an ovine model. (2014)
• PVT1 dependence in cancer with MYC copy-number increase. (2014)
• Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis. (2014)
• Choline partially prevents the impact of ethanol on the lipid raft dependent functions of l1 cell adhesion molecule. (2014)
• Gestational choline supplementation normalized fetal alcohol-induced alterations in histone modifications, DNA methylation, and proopiomelanocortin (POMC) gene expression in β-endorphin-producing POMC neurons of the hypothalamus. (2013)
• The role of cortisol in chronic binge alcohol-induced cerebellar injury: Ovine model. (2013)
• ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice. (2013)
• Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder. (2013)
• LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype. (2013)
• Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition. (2013)
• Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. (2013)
• Combined analysis of circulating β-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects. (2013)
• Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1. (2013)
• Basal regulation of HPA and dopamine systems is altered differentially in males and females by prenatal alcohol exposure and chronic variable stress. (2013)
• Dysregulation of the long non-coding RNA transcriptome in a Rett syndrome mouse model. (2013)
• Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (2013)
• Alcohol exposure during development: Impact on the epigenome. (2013)
• LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7. (2013)
• Strain dependent gene expression and neurochemical levels in the brain of zebrafish: focus on a few alcohol related targets. (2012)
• Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. (2012)
• Chronic shift-lag alters the circadian clock of NK cells and promotes lung cancer growth in rats. (2012)
• Plasma cytokine levels in children with autistic disorder and unrelated siblings. (2012)
• Chronic cocaine exposure during pregnancy increases postpartum neuroendocrine stress responses. (2012)
• Prenatal alcohol exposure alters the course and severity of adjuvant-induced arthritis in female rats. (2012)
• Cdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in mice. (2012)
• Association among SNAP-25 gene DdeI and MnlI polymorphisms and hemodynamic changes during methylphenidate use: a functional near-infrared spectroscopy study. (2011)
• Spatial organization of RYRs and BK channels underlying the activation of STOCs by Ca(2+) sparks in airway myocytes. (2011)
• CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. (2011)
• Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyces cerevisiae. (2011)
• The role of zinc in the modulation of neuronal proliferation and apoptosis. (2010)
• Phosphatidylinositol 3-kinase/protein kinase Cdelta activation induces close homolog of adhesion molecule L1 (CHL1) expression in cultured astrocytes. (2010)
• Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation. (2010)
• Sonic hedgehog signaling confers ventral telencephalic progenitors with distinct cortical interneuron fates. (2010)
• A cross-species analysis of Satb2 expression suggests deep conservation across vertebrate lineages. (2010)
• Histone methylation regulates memory formation. (2010)
• Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. (2010)
• Prenatal alcohol exposure triggers ceramide-induced apoptosis in neural crest-derived tissues concurrent with defective cranial development. (2010)
• Genetics and beyond--the transcriptome of human monocytes and disease susceptibility. (2010)
• Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort. (2010)
• Rapid, low-input, low-bias construction of shotgun fragment libraries by high-density in vitro transposition. (2010)
• Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction. (2010)
• Conserved role of intragenic DNA methylation in regulating alternative promoters. (2010)
• The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles. (2009)
• Ethanol inhibits L1 cell adhesion molecule tyrosine phosphorylation and dephosphorylation and activation of pp60(src). (2009)
• Splicing factor SFRS1 recognizes a functionally diverse landscape of RNA transcripts. (2009)
• Effects of prenatal ethanol exposure on hypothalamic-pituitary-adrenal function across the estrous cycle. (2009)
• Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation. (2009)
• Activity-dependent neuroprotective protein-derived peptide, NAP, preventing alcohol-induced apoptosis in fetal brain of C57BL/6 mouse. (2009)
• Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease. (2009)
• An alcohol binding site on the neural cell adhesion molecule L1. (2008)
• Modeling the impact of alcohol on cortical development in a dish: strategies from mapping neural stem cell fate. (2008)
• Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state. (2008)
• Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans. (2008)
• Mechanism of alcohol-induced oxidative stress and neuronal injury. (2008)
• The role of cytoplasmic serine residues of the cell adhesion molecule L1 in neurite outgrowth, endocytosis, and cell migration. (2007)
• Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes. (2007)
• Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system. (2007)
• PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis. (2007)
• Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. (2007)
• Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion. (2006)
• Dynamic reprogramming of DNA methylation at an epigenetically sensitive allele in mice. (2006)
• Nicotinamide protects against ethanol-induced apoptotic neurodegeneration in the developing mouse brain. (2006)
• Origin of oligodendrocytes in the subventricular zone of the adult brain. (2006)
• Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms. (2003)
• Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death. (2002)
• Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. (2002)
• Myelination is altered in insulin-like growth factor-I null mutant mice. (2002)
• Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain. (2001)
• Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner. (2001)
• In utero cocaine-induced dysfunction of dopamine D1 receptor signaling and abnormal differentiation of cerebral cortical neurons. (2000)
• Biochemical and morphometric analyses show that myelination in the insulin-like growth factor 1 null brain is proportionate to its neuronal composition. (1998)
• Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor. (1997)

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