Mapt gene
Evidence from:
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all sources
Related entities (19)
| Subject | Relation | Object | p-value | Evidence |
|---|---|---|---|---|
| hyperphosphorylated tau | regulates | Mapt | — | 1 |
| Mapt | associated_with | alcohol | — | 1 |
| Mapt | associated_with | Alzheimer's disease | — | 2 |
| Mapt | biomarker_for | Alzheimer's disease | — | 1 |
| Mapt | associated_with | Alzheimer’s disease | — | 1 |
| Mapt | associated_with | AUDIT | 1.07e-06 | 1 |
| Mapt | associated_with | AUDIT-C | — | 1 |
| Mapt | expressed_in | cerebellum | — | 1 |
| Mapt | risk_factor_for | dementia | — | 1 |
| Mapt | regulates | human brain | — | 1 |
| Mapt | expressed_in | NAc | — | 1 |
| Mapt | risk_factor_for | neurodegeneration | — | 1 |
| Mapt | expressed_in | neurofibrillary tangles | — | 1 |
| Mapt | expressed_in | neurons | — | 1 |
| Mapt | associated_with | neuroticism | — | 1 |
| Mapt | associated_with | Parkinson’s disease | — | 1 |
| Mapt | biomarker_for | phosphorylated tau | — | 1 |
| Mapt | risk_factor_for | Post-Traumatic Stress Disorder | — | 1 |
| Mapt | associated_with | pulmonary fibrosis | — | 1 |
Mentioned in (53)
Papers in which this entity is mentioned.
- Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder. (2024)
- Impact of alcohol exposure on neural development and network formation in human cortical organoids. (2023)
- Human 3D brain organoids: steering the demolecularization of brain and neurological diseases. (2023)
- Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals. (2023)
- Towards understandings of serine/arginine-rich splicing factors. (2023)
- Epigenetics in Alzheimer's Disease. (2022)
- Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts. (2022)
- Gene-based polygenic risk scores analysis of alcohol use disorder in African Americans. (2022)
- Alternative splicing: Human disease and quantitative analysis from high-throughput sequencing. (2021)
- A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. (2021)
- Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease. (2021)
- TGF-β/Smad3 Signalling Modulates GABA Neurotransmission: Implications in Parkinson's Disease. (2020)
- A review on neuroimaging studies of genetic and environmental influences on early brain development. (2019)
- Identification of common genetic risk variants for autism spectrum disorder. (2019)
- Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. (2019)
- Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility. (2018)
- Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. (2018)
- Long-term ethanol exposure: Temporal pattern of microRNA expression and associated mRNA gene networks in mouse brain. (2018)
- ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease. (2017)
- Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations. (2017)
- Novel genetic loci underlying human intracranial volume identified through genome-wide association. (2016)
- Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells. (2016)
- Prenatal Exposure to Arsenic Impairs Behavioral Flexibility and Cortical Structure in Mice. (2016)
- Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes. (2016)
- Oxidative stress signaling to chromatin in health and disease. (2016)
- Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. (2015)
- Induced neuronal reprogramming. (2014)
- Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice. (2014)
- Physical exercise-induced adult neurogenesis: a good strategy to prevent cognitive decline in neurodegenerative diseases? (2014)
- G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain. (2013)
- ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice. (2013)
- Long-lasting neural circuit dysfunction following developmental ethanol exposure. (2013)
- Common inversion polymorphism at 17q21.31 affects expression of multiple genes in tissue-specific manner. (2012)
- Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. (2012)
- Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. (2011)
- Spatio-temporal transcriptome of the human brain. (2011)
- Role of ubiquitin-proteasome-mediated proteolysis in nervous system disease. (2011)
- Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies. (2011)
- The role of DYRK1A in neurodegenerative diseases. (2011)
- Down syndrome: searching for the genetic culprits. (2011)
- Apolipoprotein E: from lipid transport to neurobiology. (2011)
- S100B and APP promote a gliocentric shift and impaired neurogenesis in Down syndrome neural progenitors. (2011)
- Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging. (2011)
- Transgenic mouse models of Alzheimer's disease. (2010)
- Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. (2010)
- A syndrome of short stature, microcephaly and speech delay is associated with duplications reciprocal to the common Sotos syndrome deletion. (2010)
- Dyrk1A overexpression inhibits proliferation and induces premature neuronal differentiation of neural progenitor cells. (2010)
- Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease. (2010)
- Down syndrome--recent progress and future prospects. (2009)
- Genomewide association studies and human disease. (2009)
- Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling. (2008)
- HITS-CLIP yields genome-wide insights into brain alternative RNA processing. (2008)
- Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis. (1995)
Merged raw entities (10)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| mapt | gene | 51 | 118 |
| tau | gene | 7 | 8 |
| at180 | gene | 1 | 1 |
| at8 | gene | 1 | 1 |
| microtubule associated protein tau | gene | — | — |
| microtubule-associated protein tau | gene | — | — |
| tau5 | gene | — | — |
| tau gene | gene | — | — |
| tau protein | gene | — | — |
| total-tau | gene | — | — |