DISC1 gene

Aliases: DISC1 L, DISC1 L isoform, DISC1 locus, Disrupted in Schizophrenia 1, Disrupted in schizophrenia 1, Disrupted-in-Schizophrenia 1, TRAX/DISC1, disrupted in schizophrenia 1
External links: NCBI Gene · Ensembl · GeneCards · UniProt

Evidence from: primary | all sources

Related entities (29)

Subject	Relation	Object	p-value	Evidence
CCDC88A	interacts_with	DISC1	—	1
DISC1	associated_with	1000 Genomes Project	—	1
DISC1	risk_factor_for	alcohol dependence	—	1
DISC1	associated_with	anxiety	—	1
DISC1	regulates	ATF4	—	1
DISC1	associated_with	autism spectrum disorder	—	1
DISC1	associated_with	BD	—	1
DISC1	associated_with	bipolar disorder	—	2
DISC1	risk_factor_for	bipolar disorder	—	2
DISC1	risk_factor_for	cocaine	—	1
DISC1	associated_with	cognition	—	1
DISC1	associated_with	corpus callosum	—	1
DISC1	associated_with	depression	0.0092	1
DISC1	interacts_with	GSK3B	—	1
DISC1	biomarker_for	Lothian Birth Cohort 1936	—	1
DISC1	associated_with	major depressive disorder	—	2
DISC1	associated_with	nicotine	—	1
DISC1	risk_factor_for	opioid dependence	—	1
DISC1	associated_with	psychiatric disorders	—	2
DISC1	risk_factor_for	recurrent major depressive disorder	—	1
DISC1	associated_with	recurrent major depressive disorder	—	1
DISC1	risk_factor_for	schizophrenia	—	3
DISC1	associated_with	schizophrenia	—	4
DISC1	associated_with	substance use	—	1
DISC1	associated_with	SZ	—	1
t(1;11) translocation	associated_with	DISC1	—	1
t(1;11) translocation	interacts_with	DISC1	—	1
TSNAX	associated_with	DISC1	—	1
TSNAX	interacts_with	DISC1	—	1

Mentioned in (35)

Papers in which this entity is mentioned.

Effect of schizophrenia common variants on infant brain volumes: cross-sectional study in 207 term neonates in developing Human Connectome Project. (2023)
Human 3D brain organoids: steering the demolecularization of brain and neurological diseases. (2023)
Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders. (2023)
Virtual Ontogeny of Cortical Growth Preceding Mental Illness. (2022)
FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors. (2021)
Gene Expression in Patient-Derived Neural Progenitors Implicates WNT5A Signaling in the Etiology of Schizophrenia. (2020)
Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders. (2019)
A review on neuroimaging studies of genetic and environmental influences on early brain development. (2019)
De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies. (2019)
Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders. (2019)
Imaging structural and functional brain development in early childhood. (2018)
Effect of Neuroinflammation on Synaptic Organization and Function in the Developing Brain: Implications for Neurodevelopmental and Neurodegenerative Disorders. (2017)
Evolutionary Insights into RNA trans-Splicing in Vertebrates. (2016)
Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model. (2015)
Long Noncoding RNA-Directed Epigenetic Regulation of Gene Expression Is Associated With Anxiety-like Behavior in Mice. (2015)
Impact of prenatal environmental stress on cortical development. (2015)
Evaluating historical candidate genes for schizophrenia. (2015)
Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans. (2015)
708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits. (2014)
Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. (2014)
Heritability and genomics of gene expression in peripheral blood. (2014)
Genetic influences on brain developmental trajectories on neuroimaging studies: from infancy to young adulthood. (2014)
Common variants in psychiatric risk genes predict brain structure at birth. (2014)
Rethinking schizophrenia in the context of normal neurodevelopment. (2013)
Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders. (2012)
DISC1 at 10: connecting psychiatric genetics and neuroscience. (2011)
Strain differences in developmental vulnerability to alcohol exposure via embryo culture in mice. (2011)
The neuronal transporter gene SLC6A15 confers risk to major depression. (2011)
Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. (2010)
A 1q42 deletion involving DISC1, DISC2, and TSNAX in an autism spectrum disorder. (2009)
Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. (2009)
The embryonic preoptic area is a novel source of cortical GABAergic interneurons. (2009)
Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. (2008)
The changing impact of genes and environment on brain development during childhood and adolescence: initial findings from a neuroimaging study of pediatric twins. (2008)
Genetic and environmental factors in complex neurodevelopmental disorders. (2007)

Merged raw entities (7)

All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.

Raw name	Type	Papers	Mentions
disc1	gene	35	119
disc1 l	gene	—	—
disc1 l isoform	gene	—	—
disc1 locus	gene	—	—
disrupted in schizophrenia 1	gene	—	—
disrupted-in-schizophrenia 1	gene	—	—
trax/disc1	gene	—	—