β-secretase drug
Evidence from:
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all sources
Related entities (13)
| Subject | Relation | Object | p-value | Evidence |
|---|---|---|---|---|
| APP | interacts_with | β-secretase | — | 2 |
| hypoxia | regulates | β-secretase | — | 1 |
| β-secretase | regulates | Amyloid beta | — | 2 |
| β-secretase | interacts_with | APP | — | 1 |
| β-secretase | targets | APP | — | 1 |
| β-secretase | regulates | APP | — | 1 |
| β-secretase | regulates | Aβ production | — | 1 |
| β-secretase | associated_with | high line | — | 1 |
| β-secretase | expressed_in | neurons | — | 1 |
| β-secretase | expressed_in | nucleus accumbens shell | — | 1 |
| β-secretase | expressed_in | prelimbic cortex | — | 1 |
| β-secretase | regulates | β-amyloid | — | 1 |
| β-secretase inhibitor | targets | β-secretase | — | 1 |
Mentioned in (6)
Papers in which this entity is mentioned.
- Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. (2018)
- Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations. (2017)
- New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy. (2014)
- Transgenic mouse models of Alzheimer's disease. (2010)
- Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease. (2009)
- The long-term stability of new hippocampal place fields requires new protein synthesis. (2004)
Merged raw entities (3)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| β-secretase | drug | 4 | 6 |
| beta-secretase | drug | 2 | 2 |
| bace1 | drug | — | — |