Amyloid beta drug

Aliases: Aβ, Aβ oligomers, oligomeric Aβ
External links: DrugBank · PubChem

Evidence from: primary | all sources

Related entities (49)

Subject	Relation	Object	p-value	Evidence
aging	risk_factor_for	Amyloid beta	—	1
agonist	regulates	Amyloid beta	—	1
Amyloid beta	associated_with	Alzheimer's disease	—	3
Amyloid beta	biomarker_for	Alzheimer's disease	—	3
Amyloid beta	risk_factor_for	Alzheimer’s disease	—	1
Amyloid beta	associated_with	Alzheimer’s disease	—	1
Amyloid beta	expressed_in	APP-transgenic mice	—	1
Amyloid beta	associated_with	blood-brain barrier	—	1
Amyloid beta	expressed_in	brain	—	1
Amyloid beta	risk_factor_for	brain volume	—	1
Amyloid beta	expressed_in	hippocampus	—	1
Amyloid beta	interacts_with	MAP2	—	1
Amyloid beta	expressed_in	neocortex	—	1
Amyloid beta	regulates	neuroinflammation	—	1
Amyloid beta	risk_factor_for	neuronal loss	—	1
Amyloid beta	risk_factor_for	phosphorylated tau	—	1
Amyloid beta	associated_with	plaque	—	1
Amyloid-beta	interacts_with	Amyloid beta	—	1
apoE	interacts_with	Amyloid beta	—	2
apoE4	risk_factor_for	Amyloid beta	—	1
apoE4	regulates	Amyloid beta	—	1
apoE4	associated_with	Amyloid beta	—	1
APP	regulates	Amyloid beta	—	3
APP	associated_with	Amyloid beta	—	1
bexarotene	regulates	Amyloid beta	—	2
drug	regulates	Amyloid beta	—	1
fAD	associated_with	Amyloid beta	—	1
IDE	interacts_with	Amyloid beta	—	1
IDE	protective_against	Amyloid beta	—	1
IDE	targets	Amyloid beta	—	1
IL-1β	protective_against	Amyloid beta	—	1
IL-6	protective_against	Amyloid beta	—	1
inflammation	regulates	Amyloid beta	—	1
interferon gamma	protective_against	Amyloid beta	—	1
interferon gamma	regulates	Amyloid beta	—	1
lipopolysaccharide	protective_against	Amyloid beta	—	1
lipopolysaccharide	regulates	Amyloid beta	—	1
LRP1	interacts_with	Amyloid beta	—	2
microglia	interacts_with	Amyloid beta	—	1
MMP9	interacts_with	Amyloid beta	—	1
neuroinflammation	regulates	Amyloid beta	—	1
neuronal activity	regulates	Amyloid beta	—	1
protein kinase A	protective_against	Amyloid beta	—	1
TGFβ	interacts_with	Amyloid beta	—	1
TNFα	protective_against	Amyloid beta	—	1
TNFα	regulates	Amyloid beta	—	1
β-secretase	regulates	Amyloid beta	—	2
γ-secretase	associated_with	Amyloid beta	—	1
γ-secretase	regulates	Amyloid beta	—	1

Mentioned in (38)

Papers in which this entity is mentioned.

Human 3D brain organoids: steering the demolecularization of brain and neurological diseases. (2023)
Altered dendritic morphology in dorsolateral prefrontal cortex of nonhuman primates prenatally exposed to maternal immune activation. (2023)
Apolipoprotein E intersects with amyloid-β within neurons. (2023)
Epigenetics in Alzheimer's Disease. (2022)
Transcriptomic analyses of gastrulation-stage mouse embryos with differential susceptibility to alcohol. (2021)
A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and cognitive decline. (2021)
Cotinine: Pharmacologically Active Metabolite of Nicotine and Neural Mechanisms for Its Actions. (2021)
Transient Potassium Channels: Therapeutic Targets for Brain Disorders. (2019)
Cerebrospinal fluid and the early brain development of autism. (2018)
Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex. (2018)
Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. (2018)
PI3K Signaling in Neurons: A Central Node for the Control of Multiple Functions. (2018)
ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease. (2017)
Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations. (2017)
H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus. (2016)
Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells. (2016)
Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes. (2016)
Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice. (2016)
Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation. (2016)
Direct Transcriptional Effects of Apolipoprotein E. (2016)
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. (2014)
Brain differences in infants at differential genetic risk for late-onset Alzheimer disease: a cross-sectional imaging study. (2014)
New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy. (2014)
Physical exercise-induced adult neurogenesis: a good strategy to prevent cognitive decline in neurodegenerative diseases? (2014)
ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice. (2013)
In vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-β pathology. (2013)
Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. (2012)
Temporal order memory assessed during spatiotemporal navigation as a behavioral cognitive marker for differential Alzheimer's disease diagnosis. (2012)
Role of ubiquitin-proteasome-mediated proteolysis in nervous system disease. (2011)
The role of DYRK1A in neurodegenerative diseases. (2011)
Down syndrome: searching for the genetic culprits. (2011)
Apolipoprotein E: from lipid transport to neurobiology. (2011)
S100B and APP promote a gliocentric shift and impaired neurogenesis in Down syndrome neural progenitors. (2011)
Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging. (2011)
Transgenic mouse models of Alzheimer's disease. (2010)
Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. (2010)
Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease. (2009)
Associative learning elicits the formation of multiple-synapse boutons. (2001)

Merged raw entities (5)

All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.

Raw name	Type	Papers	Mentions
aβ	drug	27	117
amyloid beta	drug	26	42
aβ oligomers	drug	5	5
amyloid beta	phenotype	4	4
oligomeric aβ	drug	2	2