CASP3 gene

Aliases

Caspase-3, activated caspase-3, caspase-3, cleaved Caspase-3, cleaved caspase-3

External links

NCBI Gene · Ensembl · GeneCards · UniProt

Related entities (2)

Mentioned in (78)

Papers in which this entity is mentioned.

• Nanopore-based cell-free DNA fragmentation and methylation profiles from the cerebral spinal fluid of patients with lung cancer brain metastases. (2025)
• FET fusion oncoproteins disrupt physiologic DNA repair and create a targetable opportunity for ATR inhibitor therapy. (2025)
• Chronic oligodendrocyte injury in central nervous system pathologies. (2022)
• Prenatal alcohol exposure contributes to negative pregnancy outcomes by altering fetal vascular dynamics and the placental transcriptome. (2022)
• Explainable multiview framework for dissecting spatial relationships from highly multiplexed data. (2022)
• Beneficial Effects of Betaine: A Comprehensive Review. (2021)
• Neurotoxic reactive astrocytes induce cell death via saturated lipids. (2021)
• Tead transcription factors differentially regulate cortical development. (2020)
• ABHD4-dependent developmental anoikis safeguards the embryonic brain. (2020)
• Murine Models for the Study of Fetal Alcohol Spectrum Disorders: An Overview. (2020)
• Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish. (2019)
• Designing combination therapies with modeling chaperoned machine learning. (2019)
• Genome-Informed Targeted Therapy for Osteosarcoma. (2019)
• Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. (2018)
• Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. (2018)
• Orthotopic patient-derived xenografts of paediatric solid tumours. (2017)
• Epigenetics studies of fetal alcohol spectrum disorder: where are we now? (2017)
• Lipids and Oxidative Stress Associated with Ethanol-Induced Neurological Damage. (2016)
• Alteration of Gene Expression, DNA Methylation, and Histone Methylation in Free Radical Scavenging Networks in Adult Mouse Hippocampus following Fetal Alcohol Exposure. (2016)
• Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes. (2016)
• Pdgfra and Pdgfrb genetically interact during craniofacial development. (2016)
• Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse. (2016)
• CB1-receptor knockout neonatal mice are protected against ethanol-induced impairments of DNMT1, DNMT3A, and DNA methylation. (2015)
• BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells. (2015)
• MiR-125b protects against ethanol-induced apoptosis in neural crest cells and mouse embryos by targeting Bak 1 and PUMA. (2015)
• Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing. (2015)
• Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation. (2014)
• Pre-administration of G9a/GLP inhibitor during synaptogenesis prevents postnatal ethanol-induced LTP deficits and neurobehavioral abnormalities in adult mice. (2014)
• Low-dose maternal alcohol consumption: effects in the hearts of offspring in early life and adulthood. (2014)
• Ethanol exposure induces neonatal neurodegeneration by enhancing CB1R Exon1 histone H4K8 acetylation and up-regulating CB1R function causing neurobehavioral abnormalities in adult mice. (2014)
• Fetal alcohol programming of hypothalamic proopiomelanocortin system by epigenetic mechanisms and later life vulnerability to stress. (2014)
• Molecular pathways underpinning ethanol-induced neurodegeneration. (2014)
• Long-term genomic and epigenomic dysregulation as a consequence of prenatal alcohol exposure: a model for fetal alcohol spectrum disorders. (2014)
• Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice. (2014)
• Effects of one- and three-day binge alcohol exposure in neonatal C57BL/6 mice on spatial learning and memory in adolescence and adulthood. (2014)
• Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure. (2013)
• G9a-mediated histone methylation regulates ethanol-induced neurodegeneration in the neonatal mouse brain. (2013)
• Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD. (2013)
• Commonality in Down and fetal alcohol syndromes. (2013)
• Long-lasting neural circuit dysfunction following developmental ethanol exposure. (2013)
• Alcohol-induced apoptosis of oligodendrocytes in the fetal macaque brain. (2013)
• Different patterns of regional Purkinje cell loss in the cerebellar vermis as a function of the timing of prenatal ethanol exposure in an ovine model. (2013)
• Over-expression of Nrf2 diminishes ethanol-induced oxidative stress and apoptosis in neural crest cells by inducing an antioxidant response. (2013)
• Nitric oxide rescues thalidomide mediated teratogenicity. (2012)
• Distinct spatiotemporal roles of hedgehog signalling during chick and mouse cranial base and axial skeleton development. (2012)
• Does moderate drinking harm the fetal brain? Insights from animal models. (2012)
• Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. (2012)
• Early exposure to alcohol leads to permanent impairment of dendritic excitability in neocortical pyramidal neurons. (2012)
• Mutations in Hedgehog acyltransferase (Hhat) perturb Hedgehog signaling, resulting in severe acrania-holoprosencephaly-agnathia craniofacial defects. (2012)
• Postnatal day 7 ethanol treatment causes persistent reductions in adult mouse brain volume and cortical neurons with sex specific effects on neurogenesis. (2012)
• Receptor heteromerization expands the repertoire of cannabinoid signaling in rodent neurons. (2012)
• A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories. (2011)
• Strain differences in developmental vulnerability to alcohol exposure via embryo culture in mice. (2011)
• MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors. (2011)
• Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice. (2011)
• Local and regional network function in behaviorally relevant cortical circuits of adult mice following postnatal alcohol exposure. (2011)
• Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome. (2010)
• The role of zinc in the modulation of neuronal proliferation and apoptosis. (2010)
• Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. (2010)
• High-throughput caveolar proteomic signature profile for maternal binge alcohol consumption. (2010)
• The role of NOX enzymes in ethanol-induced oxidative stress and apoptosis in mouse embryos. (2010)
• Prenatal alcohol exposure triggers ceramide-induced apoptosis in neural crest-derived tissues concurrent with defective cranial development. (2010)
• The plausibility of maternal nutritional status being a contributing factor to the risk for fetal alcohol spectrum disorders: the potential influence of zinc status as an example. (2010)
• Sexual dimorphism in the white matter of rodents. (2009)
• An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. (2009)
• Evolution of the neocortex: a perspective from developmental biology. (2009)
• Effects of ethanol and ipsapirone on the expression of genes encoding anti-apoptotic proteins and an antioxidant enzyme in ethanol-treated neurons. (2009)
• Activity-dependent neuroprotective protein-derived peptide, NAP, preventing alcohol-induced apoptosis in fetal brain of C57BL/6 mouse. (2009)
• Modeling the impact of alcohol on cortical development in a dish: strategies from mapping neural stem cell fate. (2008)
• Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium. (2007)
• The proneural gene Mash1 specifies an early population of telencephalic oligodendrocytes. (2007)
• Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. (2007)
• Nicotinamide protects against ethanol-induced apoptotic neurodegeneration in the developing mouse brain. (2006)
• Macrophage-derived tumor necrosis factor alpha, an early developmental signal for motoneuron death. (2004)
• Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death. (2002)
• Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner. (2001)
• Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse. (2000)
• Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: the involvement of intracellular calcium and RNA synthesis. (1995)

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