HEPES drug

Aliases

HEPES, HEPES (pH 7.6), HEPES buffer, HEPES-based recording solution, N-[2-hydroxyethyl]piperazine-N′-[2-ethanesulfonic acid]

External links

DrugBank · PubChem

Related entities (5)

Mentioned in (104)

Papers in which this entity is mentioned.

• LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development. (2025)
• Multigenerational cell tracking of DNA replication and heritable DNA damage. (2025)
• Multi-omic quantitative trait loci link tandem repeat size variation to gene regulation in human brain. (2025)
• MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC. (2025)
• Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders. (2024)
• Global impact of unproductive splicing on human gene expression. (2024)
• Graded mesoderm assembly governs cell fate and morphogenesis of the early mammalian heart. (2023)
• Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids. (2022)
• Single-cell genomic variation induced by mutational processes in cancer. (2022)
• FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors. (2021)
• Joint single-cell measurements of nuclear proteins and RNA in vivo. (2021)
• Neurotoxic reactive astrocytes induce cell death via saturated lipids. (2021)
• Simultaneous single cell measurements of intranuclear proteins and gene expression (2021)
• Simultaneous epigenetic perturbation and genome imaging reveal distinct roles of H3K9me3 in chromatin architecture and transcription. (2020)
• Development of a high-throughput arrayed neural circuitry platform using human induced neurons for drug screening applications. (2020)
• Kcnn2 blockade reverses learning deficits in a mouse model of fetal alcohol spectrum disorders. (2020)
• PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome. (2020)
• Comprehensive analysis of structural variants in breast cancer genomes using single-molecule sequencing. (2020)
• Differential sensitivity of human neurons carrying μ opioid receptor (MOR) N40D variants in response to ethanol. (2020)
• Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. (2019)
• Programmed increases in LXRα induced by paternal alcohol use enhance offspring metabolic adaptation to high-fat diet induced obesity. (2019)
• Canonical Wnt5b Signaling Directs Outlying Nkx2.5+ Mesoderm into Pacemaker Cardiomyocytes. (2019)
• Maternal circulating miRNAs that predict infant FASD outcomes influence placental maturation. (2019)
• Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells. (2019)
• Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmission. (2018)
• Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain. (2018)
• Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication. (2018)
• EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma. (2018)
• Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish. (2017)
• Assembly of functionally integrated human forebrain spheroids. (2017)
• Alternative Polyadenylation Directs Tissue-Specific miRNA Targeting in Somatic Tissues. (2017)
• Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain. (2017)
• Impact of cytosine methylation on DNA binding specificities of human transcription factors. (2017)
• Single-Cell Profiling of an In Vitro Model of Human Interneuron Development Reveals Temporal Dynamics of Cell Type Production and Maturation. (2017)
• Musculocontractural Ehlers-Danlos syndrome and neurocristopathies: dermatan sulfate is required for Xenopus neural crest cells to migrate and adhere to fibronectin. (2016)
• H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus. (2016)
• Sustained synchronized neuronal network activity in a human astrocyte co-culture system. (2016)
• Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR(mt). (2016)
• Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. (2016)
• Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice. (2016)
• Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells. (2016)
• Increasing the GluN2A/GluN2B Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace. (2016)
• Direct Transcriptional Effects of Apolipoprotein E. (2016)
• Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors. (2015)
• Effects of ethanol exposure in utero on Cajal-Retzius cells in the developing cortex. (2015)
• Two distinct modes for propagation of histone PTMs across the cell cycle. (2015)
• Dose-dependent alcohol-induced alterations in chromatin structure persist beyond the window of exposure and correlate with fetal alcohol syndrome birth defects. (2015)
• Third trimester-equivalent ethanol exposure increases anxiety-like behavior and glutamatergic transmission in the basolateral amygdala. (2015)
• Spatial reconstruction of single-cell gene expression data. (2015)
• Moderate prenatal alcohol exposure enhances GluN2B containing NMDA receptor binding and ifenprodil sensitivity in rat agranular insular cortex. (2015)
• A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation. (2014)
• Condensins are Required for Maintenance of Nuclear Architecture. (2014)
• Simultaneous high-resolution detection of multiple transcripts combined with localization of proteins in whole-mount embryos. (2014)
• Direct functional consequences of ZRS enhancer mutation combine with secondary long range SHH signalling effects to cause preaxial polydactyly. (2014)
• Choline partially prevents the impact of ethanol on the lipid raft dependent functions of l1 cell adhesion molecule. (2014)
• ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice. (2013)
• Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. (2013)
• Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model. (2013)
• Intrinsic properties of larval zebrafish neurons in ethanol. (2013)
• In vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-β pathology. (2013)
• Dysregulation of the long non-coding RNA transcriptome in a Rett syndrome mouse model. (2013)
• Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (2013)
• Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors. (2013)
• Alcohol exposure during development: Impact on the epigenome. (2013)
• Nitric oxide rescues thalidomide mediated teratogenicity. (2012)
• Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity. (2012)
• Early exposure to alcohol leads to permanent impairment of dendritic excitability in neocortical pyramidal neurons. (2012)
• Pilot study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro. (2012)
• Ethanol metabolism and osmolarity modify behavioral responses to ethanol in C. elegans. (2012)
• Multiple dynamic representations in the motor cortex during sensorimotor learning. (2012)
• Prenatal alcohol exposure alters the course and severity of adjuvant-induced arthritis in female rats. (2012)
• Effects of ethanol and NAP on cerebellar expression of the neural cell adhesion molecule L1. (2011)
• Ethanol causes the redistribution of L1 cell adhesion molecule in lipid rafts. (2011)
• Spatial organization of RYRs and BK channels underlying the activation of STOCs by Ca(2+) sparks in airway myocytes. (2011)
• AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. (2011)
• The role of zinc in the modulation of neuronal proliferation and apoptosis. (2010)
• Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. (2010)
• Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. (2010)
• Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. (2010)
• Low concentrations of alcohol inhibit BDNF-dependent GABAergic plasticity via L-type Ca2+ channel inhibition in developing CA3 hippocampal pyramidal neurons. (2010)
• Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction. (2010)
• Cocaine exposure modulates dopamine and adenosine signaling in the fetal brain. (2010)
• The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. (2009)
• Arsenic transport by zebrafish aquaglyceroporins. (2009)
• The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. (2009)
• A novel and universal method for microRNA RT-qPCR data normalization. (2009)
• The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles. (2009)
• Ethanol inhibits L1 cell adhesion molecule tyrosine phosphorylation and dephosphorylation and activation of pp60(src). (2009)
• Repeated homotypic stress elevates 2-arachidonoylglycerol levels and enhances short-term endocannabinoid signaling at inhibitory synapses in basolateral amygdala. (2009)
• Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha. (2009)
• Activity-dependent neuroprotective protein-derived peptide, NAP, preventing alcohol-induced apoptosis in fetal brain of C57BL/6 mouse. (2009)
• The embryonic preoptic area is a novel source of cortical GABAergic interneurons. (2009)
• Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans. (2008)
• The incentive salience of alcohol: translating the effects of genetic variant in CNR1. (2008)
• Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neurons. (2008)
• Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system. (2007)
• PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis. (2007)
• Nicotinamide protects against ethanol-induced apoptotic neurodegeneration in the developing mouse brain. (2006)
• Sexually dimorphic synaptic organization of the medial amygdala. (2005)
• Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity. (2005)
• Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. (2003)
• Relationship between availability of NMDA receptor subunits and their expression at the synapse. (2002)
• Coupled and uncoupled proton movement by amino acid transport system N. (2001)
• In utero cocaine-induced dysfunction of dopamine D1 receptor signaling and abnormal differentiation of cerebral cortical neurons. (2000)

Merged raw entities (4)

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