Tris-HCl drug

Aliases

Tris hydrochloride, Tris-HCl (pH 7.6), Tris–HCl

External links

DrugBank · PubChem

Related entities (8)

Mentioned in (97)

Papers in which this entity is mentioned.

• Single-cell exon deletion profiling reveals splicing events that shape gene expression and cell state dynamics. (2026)
• LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development. (2025)
• Nanopore-based cell-free DNA fragmentation and methylation profiles from the cerebral spinal fluid of patients with lung cancer brain metastases. (2025)
• FET fusion oncoproteins disrupt physiologic DNA repair and create a targetable opportunity for ATR inhibitor therapy. (2025)
• Connectome-seq: High-throughput Mapping of Neuronal Connectivity at Single-Synapse Resolution via Barcode Sequencing. (2025)
• Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder. (2025)
• Integrated single-cell multiomic profiling of caudate nucleus suggests key mechanisms in alcohol use disorder. (2025)
• Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. (2025)
• Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders. (2024)
• Sequence modeling and design from molecular to genome scale with Evo. (2024)
• Detection and analysis of complex structural variation in human genomes across populations and in brains of donors with psychiatric disorders. (2024)
• Integrated Single-Cell Multiomic Profiling of Caudate Nucleus Suggests Key Mechanisms in Alcohol Use Disorder. (2024)
• Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells. (2024)
• Alcohol blunts pregnancy-mediated insulin resistance and reduces fetal brain glucose despite elevated fetal gluconeogenesis, and these changes associate with fetal weight outcomes. (2023)
• Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking. (2022)
• Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids. (2022)
• Integrated Genomic Analysis Identifies Driver Genes and Cisplatin-Resistant Progenitor Phenotype in Pediatric Liver Cancer. (2021)
• Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease. (2021)
• Simultaneous epigenetic perturbation and genome imaging reveal distinct roles of H3K9me3 in chromatin architecture and transcription. (2020)
• UMI-linked consensus sequencing enables phylogenetic analysis of directed evolution. (2020)
• ABHD4-dependent developmental anoikis safeguards the embryonic brain. (2020)
• Nanopore sequencing and the Shasta toolkit enable efficient de novo assembly of eleven human genomes. (2020)
• Folding Keratin Gene Clusters during Skin Regional Specification. (2020)
• An interaction between fetal sex and placental weight and efficiency predicts intrauterine growth in response to maternal protein insufficiency and gestational exposure window in a mouse model of FASD. (2020)
• Reciprocal monoallelic expression of ASAR lncRNA genes controls replication timing of human chromosome 6. (2020)
• Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals. (2019)
• Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. (2019)
• Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways. (2019)
• Alcohol metabolism contributes to brain histone acetylation. (2019)
• Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. (2018)
• Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3β Are Modulators of Anxiety and Glutamatergic Neurotransmission. (2018)
• Oxytocin Receptor Gene Variant Interacts with Intervention Delivery Format in Predicting Intervention Outcomes for Youth with Conduct Problems. (2018)
• Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication. (2018)
• An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues. (2017)
• The acute effect of cannabis on plasma, liver and brain ammonia dynamics, a translational study. (2017)
• Maternal choline supplementation during murine pregnancy modulates placental markers of inflammation, apoptosis and vascularization in a fetal sex-dependent manner. (2017)
• A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. (2017)
• Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain. (2017)
• Ethanol itself is a holoprosencephaly-inducing teratogen. (2017)
• Impact of cytosine methylation on DNA binding specificities of human transcription factors. (2017)
• PGBD5 promotes site-specific oncogenic mutations in human tumors. (2017)
• Musculocontractural Ehlers-Danlos syndrome and neurocristopathies: dermatan sulfate is required for Xenopus neural crest cells to migrate and adhere to fibronectin. (2016)
• Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress. (2016)
• Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice. (2016)
• Increasing the GluN2A/GluN2B Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace. (2016)
• Establishment of human iPSC-based models for the study and targeting of glioma initiating cells. (2016)
• Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors. (2015)
• EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions. (2015)
• Two distinct modes for propagation of histone PTMs across the cell cycle. (2015)
• Spatial reconstruction of single-cell gene expression data. (2015)
• Prenatal arsenic exposure alters the programming of the glucocorticoid signaling system during embryonic development. (2015)
• BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells. (2015)
• CtBP2 is an independent prognostic marker that promotes GLI1 induced epithelial-mesenchymal transition in hepatocellular carcinoma. (2015)
• A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation. (2014)
• Brain region- and sex-specific alterations in DAMGO-stimulated [(35) S]GTPγS binding in mice with Oprm1 A112G. (2014)
• PVT1 dependence in cancer with MYC copy-number increase. (2014)
• Fate analysis of adult hippocampal progenitors in a murine model of fetal alcohol spectrum disorder (FASD). (2013)
• LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype. (2013)
• Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas. (2013)
• Dysregulation of the long non-coding RNA transcriptome in a Rett syndrome mouse model. (2013)
• Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. (2013)
• Oncostatin M decreases interleukin-1 β secretion by human synovial fibroblasts and attenuates an acute inflammatory reaction in vivo. (2012)
• In vivo genome editing using a high-efficiency TALEN system. (2012)
• Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. (2012)
• A limited access mouse model of prenatal alcohol exposure that produces long-lasting deficits in hippocampal-dependent learning and memory. (2012)
• miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. (2012)
• Cdon mutation and fetal ethanol exposure synergize to produce midline signaling defects and holoprosencephaly spectrum disorders in mice. (2012)
• CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. (2011)
• The serotonin transporter gene and startle response during nicotine deprivation. (2011)
• The role of zinc in the modulation of neuronal proliferation and apoptosis. (2010)
• Phosphatidylinositol 3-kinase/protein kinase Cdelta activation induces close homolog of adhesion molecule L1 (CHL1) expression in cultured astrocytes. (2010)
• Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. (2010)
• Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. (2010)
• The role of NOX enzymes in ethanol-induced oxidative stress and apoptosis in mouse embryos. (2010)
• Conserved role of intragenic DNA methylation in regulating alternative promoters. (2010)
• The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. (2009)
• The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation are linked to IRAK-M in human monocytes. (2009)
• Sonic hedgehog ligand partners with caveolin-1 for intracellular transport. (2009)
• Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation. (2009)
• Novel neuroprotective mechanisms of memantine: increase in neurotrophic factor release from astroglia and anti-inflammation by preventing microglial activation. (2009)
• Effects of ethanol and ipsapirone on the expression of genes encoding anti-apoptotic proteins and an antioxidant enzyme in ethanol-treated neurons. (2009)
• Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state. (2008)
• Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans. (2008)
• Mechanism of alcohol-induced oxidative stress and neuronal injury. (2008)
• Perinatal choline deficiency produces abnormal sensory inhibition in Sprague-Dawley rats. (2008)
• Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system. (2007)
• Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. (2007)
• Nicotinamide protects against ethanol-induced apoptotic neurodegeneration in the developing mouse brain. (2006)
• Origin of oligodendrocytes in the subventricular zone of the adult brain. (2006)
• Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. (2005)
• Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2. (2003)
• Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death. (2002)
• Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain. (2001)
• In utero cocaine-induced dysfunction of dopamine D1 receptor signaling and abnormal differentiation of cerebral cortical neurons. (2000)
• Biochemical and morphometric analyses show that myelination in the insulin-like growth factor 1 null brain is proportionate to its neuronal composition. (1998)
• EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes. (1998)
• Gestational exposure to ethanol suppresses msx2 expression in developing mouse embryos. (1997)

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