γ-secretase drug
Evidence from:
primary |
all sources
Related entities (10)
| Subject | Relation | Object | p-value | Evidence |
|---|---|---|---|---|
| APP | interacts_with | γ-secretase | — | 1 |
| compound E | targets | γ-secretase | — | 3 |
| hypoxia | regulates | γ-secretase | — | 1 |
| PSEN1 | regulates | γ-secretase | — | 1 |
| γ-secretase | associated_with | Amyloid beta | — | 1 |
| γ-secretase | regulates | Amyloid beta | — | 1 |
| γ-secretase | interacts_with | APP | — | 1 |
| γ-secretase | targets | APP | — | 1 |
| γ-secretase | regulates | APP | — | 1 |
| γ-secretase | regulates | Aβ production | — | 1 |
Mentioned in (14)
Papers in which this entity is mentioned.
- TGF-β/Smad3 Signalling Modulates GABA Neurotransmission: Implications in Parkinson's Disease. (2020)
- Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. (2018)
- Slit-Robo signalling in heart development. (2018)
- An Update on Non-CB, Non-CB Cannabinoid Related G-Protein-Coupled Receptors. (2017)
- Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations. (2017)
- Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells. (2016)
- Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes. (2016)
- Low Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell Function. (2016)
- New therapeutic approaches for Alzheimer's disease and cerebral amyloid angiopathy. (2014)
- Physical exercise-induced adult neurogenesis: a good strategy to prevent cognitive decline in neurodegenerative diseases? (2014)
- Low density lipoprotein receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes. (2013)
- Transgenic mouse models of Alzheimer's disease. (2010)
- Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease. (2009)
- Neuregulin 1 in neural development, synaptic plasticity and schizophrenia. (2008)
Merged raw entities (4)
All extracted name/type variants the normalize job merged into this entity. Use this to spot wrong merges, or aliases that should be split off.
| Raw name | Type | Papers | Mentions |
|---|---|---|---|
| γ-secretase | drug | 12 | 26 |
| γ-secretase | gene | 4 | 4 |
| gamma-secretase | drug | 2 | 3 |
| gamma secretase | drug | — | — |