CB1 receptor associated_with GAD1

Subject: CB1 receptor
Relation: associated_with
Object: GAD1
p-value: 0.001

Evidence from: primary | all sources

Evidence (2 sources)

Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia. (2012) PMID:22036037 cited

alterations in CB1R and GAD67 mRNA expression in schizophrenia are strongly correlated (r=0.64; p=0.001)

confidence: 0.95

Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia. (2012) PMID:22036037 cited

lower density of CB1Rs could be an adaptation that partially compensates for upstream reductions in GAD67-mediated GABA synthesis

confidence: 0.90