de novo variant risk_factor_for schizophrenia
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Evidence (6 sources)
Copy number variation: what is it and what has it told us about child psychiatric disorders?
(2013)
PMID:23880486
cited
Such mutations are associated with risk of ... schizophrenia
confidence: 0.95
Rate ... comparable to the rate we observed in schizophrenia (4.5%) using the same methods.
confidence: 0.94
In the first systematic study of de novo CNVs in schizophrenia, Xu et al. observed a high rate ... Subsequent studies ... also observed a high rate of de novo CNVs in schizophrenia.
confidence: 0.95
overall contribution of de novo CNVs ... to disease risk could be substantial ... for BD and SCZ.
confidence: 0.85
de novo CNVs occur at a significantly increased rate in individuals with schizophrenia
confidence: 0.94
De novo CNVs have consistently shown the strongest association with risk for ... schizophrenia ... with a 5- to 10-fold enrichment in patients.
confidence: 0.95