high-fat diet risk_factor_for glucose intolerance

In response to glucose challenge, the HFD-fed cyp2a5−/− mice exhibited a more severe glucose intolerance than the HFD-fed cyp2a5+/+ mice did.

HFD feeding worsen the glucose intolerance in P+A- mice but HFD had no effect on glucose intolerance in P-A- mice and P-A+ mice