rs16969968 interacts_with nicotinic agonist

Subject: rs16969968
Relation: interacts_with
Object: nicotinic agonist
p-value: 0.0001

Evidence from: primary | all sources

Evidence (1 sources)

A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy. (2009) PMID:19429911 cited

The minor allele of the missense polymorphism ... rs16969968 ... conferred a reduced response to a nicotinic agonist in vitro (P < 0.0001).

confidence: 0.95