PKA regulates GABAA receptor

Chronic activation of PKA in cerebellar granule cells increases cell surface expression of GABAA receptor α1 subunit

PKA phosphorylation of GABAA receptors decreases receptor activation

Several protein kinases, including ... PKA, have consensus sites on GABAA receptor subunits and can phosphorylate these subunits

effects of these protein kinases on other ion channels interfere with therapeutic strategies for modulation of GABAA receptors.

PKA has been shown to alter GABAA receptor function