nicotine regulates dopamine

Subject: nicotine
Relation: regulates
Object: dopamine
p-value: 0.0001

Evidence from: primary | all sources

Evidence (6 sources)

A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism. (2015) PMID:26407342 cited

nicotine ... increases dopamine levels in the nucleus accumbens

confidence: 0.96

Maturation of the adolescent brain. (2013) PMID:23579318 cited

dopamine is increased by nicotine

confidence: 0.95

Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior. (2012) PMID:23040810 cited

increases release of DA from the midbrain projections to the NAc

confidence: 0.90

Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. (2012) PMID:22290489 cited

Nicotine stimulates release of dopamine in the mesoaccumbens reward pathway

confidence: 0.94

Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. (2011) PMID:20801430 cited

nicotine-induced increases of dopamine levels in the nucleus accumbens

confidence: 0.85

Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. (2011) PMID:20801430 cited

systemic injection of 0.4 mg/kg nicotine increased extracellular dopamine levels in the nucleus accumbens shell

confidence: 0.96