years of education protective_against major depressive disorder

Subject: years of education
Relation: protective_against
Object: major depressive disorder
p-value: 2.3e-06

Evidence from: primary | all sources

Evidence (2 sources)

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. (2018) PMID:29700475 cited

0.84-fold decrease in major depression per standard deviation of EDY (PGSMR=2.3×10−6)

confidence: 0.90

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. (2018) PMID:29700475 cited

significant negative genetic correlations with years of education ... MR analysis results are consistent with years of education being causal ... indicating a protective effect against major depression

confidence: 0.86