CLTCL1 risk_factor_for autism

Subject: CLTCL1
Relation: risk_factor_for
Object: autism
p-value: 0.042

Evidence from: primary | all sources

Evidence (2 sources)

Whole-exome sequencing and homozygosity analysis implicate depolarization-regulated neuronal genes in autism. (2012) PMID:22511880 cited

One gene, CLTCL1, especially stood out ... having 17 mutations in cases versus 6 mutations in controls (P = 0.042).

confidence: 0.95

Whole-exome sequencing and homozygosity analysis implicate depolarization-regulated neuronal genes in autism. (2012) PMID:22511880 cited

Regulation of expression of several potential recessive autism genes ... (UBE3B, CLTCL1, NCKAP5L, ZNF18) suggests they may lead to dysfunction in autism spectrum disorders.

confidence: 0.85