Chrm1 interacts_with phospholipase C

Subject: Chrm1
Relation: interacts_with
Object: phospholipase C
p-value: —

Evidence from: primary | all sources

Evidence (2 sources)

Cholinergic modulation of synaptic integration and dendritic excitability in the striatum. (2011) PMID:21550798 cited

M1 receptor activation ... via phospholipase C (PLC) ... pathway.

confidence: 0.80

Cholinergic modulation of synaptic integration and dendritic excitability in the striatum. (2011) PMID:21550798 cited

M1 receptor activation reduces channel opening by activating PLC and lowering membrane PtdIns(4,5)P2 (PIP2) levels.

confidence: 0.90