naltrexone protective_against craving

twelve weeks of NTX treatment relative to placebo was associated with reductions in craving for alcohol

G allele carriers were less likely to crave alcohol when treated with NTX relative to placebo (p < 0.05)

Over time patients experience reduced levels of craving for alcohol.

greater naltrexone‑induced blunting of alcohol craving as compared to G‑allele homozygotes

naltrexone ... attenuated alcohol craving

Both antagonists reduce drinking and craving in alcoholic individuals in treatment and also in heavy drinkers.

craving ... are blunted by naltrexone, particularly for those with the G allele