PCLO risk_factor_for mood disorders
Evidence from:
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Evidence (7 sources)
Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
(2011)
PMID:20038947
cited
The strongest signal in the published GAIN-MDD GWAS was in PCLO (P = 7.7 × 10−7)...
confidence: 0.95
Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.
(2009)
PMID:19065144
cited
genetic variation in PCLO might be causal to the types of MDD seen in community samples
confidence: 0.90
Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.
(2009)
PMID:19065144
cited
PCLO ... clearly intersecting with a venerable hypothesis of the etiology of mood disorders
confidence: 0.60
Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.
(2009)
PMID:19065144
cited
did not reach the a priori criterion for replication evidence for the involvement of PCLO in the etiology of MDD.
confidence: 0.70
Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.
(2009)
PMID:19065144
cited
genetic variation in PCLO is etiologically causal to some subtypes of MDD
confidence: 0.80
Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.
(2009)
PMID:19065144
cited
plausibility of a role for PCLO in the etiology of MDD
confidence: 0.90
Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo.
(2009)
PMID:19065144
cited
involvement in monoamine neurotransmission, a venerable hypothesis of the etiology of MDD
confidence: 0.80