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ondansetron protective_against opioid withdrawal

Subject
ondansetron
Relation
protective_against
Object
opioid withdrawal
p-value
0.0313
Evidence from: primary | all sources

Evidence (4 sources)

From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics. (2009) PMID:19214139 cited
Ondansetron reduced naloxone-precipitated withdrawal
confidence: 0.90
From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics. (2009) PMID:19214139 cited
simultaneous administration of ondansetron ... diminished the naloxone-precipitated withdrawal response
confidence: 0.95
From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics. (2009) PMID:19214139 cited
Ondansetron pretreatment caused a substantial (76.4%±22.6) and statistically significant (P=0.0313) decrease in mean OOWS score.
confidence: 0.90
From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics. (2009) PMID:19214139 cited
a 5-HT3 receptor antagonist reduced two distinct manifestations of opioid withdrawal in mice
confidence: 0.95