Clu risk_factor_for Alzheimer’s disease
Evidence from:
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Evidence (5 sources)
Interpretation of risk loci from genome-wide association studies of Alzheimer's disease.
(2020)
PMID:31986256
cited
identified common or rare functional variants in APOE, CR1, BIN1, TREM2, CLU, ...
confidence: 0.90
Interpretation of risk loci from genome-wide association studies of Alzheimer's disease.
(2020)
PMID:31986256
cited
Functional genomics studies further suggests ... CLU ... as the likely causal genes in their respective loci
confidence: 0.94
Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility.
(2018)
PMID:30297968
cited
The PTK2B/CLU locus shows independent co‑localized association for both GWAS and splicing effects in Alzheimer’s disease.
confidence: 0.90
Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility.
(2018)
PMID:30297968
cited
These analyses confirmed many of the known Alzheimer’s disease genes (i.e., CLU ...)
confidence: 0.96
Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility.
(2018)
PMID:30297968
cited
specific splicing mechanism for the Alzheimer’s disease risk alleles at CLU
confidence: 0.90