SH2B1 risk_factor_for obesity
Evidence from:
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Evidence (4 sources)
Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity.
(2013)
PMID:23554873
cited
haploinsufficiency of SH2B1 is the primary cause of obesity in these individuals
confidence: 0.90
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
(2010)
PMID:20935630
cited
Each of these genes has been tied to obesity... SH2B1 ... lead to severe obesity.
confidence: 0.96
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
(2009)
PMID:19079261
cited
alteration in SH2B1 function as the causal mechanism for influencing obesity
confidence: 0.90
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
(2009)
PMID:19079261
cited
Disruption in mice of Sh2b1 ... results in ... obesity
confidence: 0.85