rs563649 regulates OPRM1
Evidence from:
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Evidence (3 sources)
rs563649 is located within a structurally conserved IRES in the 5′ UTR of a novel exon 13 in an OPRM1 isoform and affects mRNA levels and translation efficiency.
confidence: 0.96
Expansion of the human mu-opioid receptor gene architecture: novel functional variants.
(2009)
PMID:19103668
cited
the exact molecular mechanism by which rs563649 regulates OPRM1 function and pain signaling requires further studies
confidence: 0.95
Expansion of the human mu-opioid receptor gene architecture: novel functional variants.
(2009)
PMID:19103668
cited
SNP rs563649 is located within the 5′-UTR of MOR-1K transcripts, suggesting it can affect expression or function of the MOR-1K isoforms (OPRM1).
confidence: 0.95