rs16969968 risk_factor_for lung cancer
Evidence from:
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Evidence (8 sources)
high-risk rs16969968-AA genotype was associated with a 4-year earlier median age of lung cancer diagnosis
confidence: 0.93
The Asn398 allele ... increased susceptibility to develop lung cancer.
confidence: 0.90
Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC.
(2011)
PMID:21862624
cited
Both rs16969968 (OR=1.31, 95%CI 1.16-1.48, P<0.001) ... were associated with risk ...
confidence: 0.96
Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC.
(2011)
PMID:21862624
cited
In current smokers rs16969968 increased lung cancer risk (OR=1.39, P<0.001) and in former smokers (OR=1.31, P=0.01).
confidence: 0.95
Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.
(2010)
PMID:19896728
cited
The variant CHRNA5 (D398N), which greatly increases the risk for ... lung cancer ...
confidence: 0.96
Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.
(2010)
PMID:19896728
cited
the polymorphism likely has a direct role in the etiology of lung cancer
confidence: 0.90
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
(2009)
PMID:19706762
cited
Genome-wide studies of lung cancer report strong association with rs16969968 ...
confidence: 0.95
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
(2009)
PMID:19706762
cited
rs16969968 ... is clearly implicated in risk for ... lung cancer in individuals of European descent
confidence: 0.95