GABA targets GABAA receptor

Subject: GABA
Relation: targets
Object: GABAA receptor
p-value: —

Evidence from: primary | all sources

Evidence (7 sources)

GABRA2 markers moderate the subjective effects of alcohol. (2013) PMID:22501025 cited

The actions of GABA are mediated by receptors belonging to two major classes, termed GABAA and GABAB.

confidence: 0.94

Pilot study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro. (2012) PMID:22486492 cited

A 50µM GABA puff produced an inward current response, indicating activation of GABAA receptors.

confidence: 0.94

How inhibition shapes cortical activity. (2011) PMID:22017986 cited

GABA evokes fast inhibition via anion ... permeable GABAA receptor-mediated conductances

confidence: 0.96

The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. (2009) PMID:19455309 cited

The neurotransmitter GABA binds to these receptors, changing their conformation state

confidence: 0.95

GABA A receptors: subtypes provide diversity of function and pharmacology. (2009) PMID:18760291 cited

GABA ... mediates rapid inhibition via GABAA receptors

confidence: 0.95

GABA A receptors: subtypes provide diversity of function and pharmacology. (2009) PMID:18760291 cited

Binding of drugs into any one of these sites could either stabilize or induce conformational changes of the receptor and thus, enhance or reduce GABA‑induced chloride flux.

confidence: 0.90

GABA A receptors: subtypes provide diversity of function and pharmacology. (2009) PMID:18760291 cited

the two pockets at the β/α interfaces form the 2 GABA binding sites

confidence: 0.97