PPARα regulates Fgf21

PPARα regulates lipid metabolism through FGF21

PPARα regulates interaction ... through the liver released FGF21

FGF21 mRNA was used as a measure of PPARα activity and was strictly PPARα dependent.

fasting-induced FGF21 expression/production was strictly dependent on PPARα hepatic activity

PPARα regulates the expression of the fibroblast growth factor 21 (FGF21) during starvation.

These include PPARα/γ ... that are involved in metabolic stress responses regulate FGF21 expression.

In response to fasting or a ketogenic diet, FGF21 expression is induced primarily in the liver through the action of PPARα