CYP2A6 associated_with NMR

four characterized reduced-activity variants (CYP2A6*2, CYP2A6*4, CYP2A6*9, and CYP2A6*12) ... accounted for ... variance in NMR

Variance in NMR explained by the known CYP2A6 alleles was estimated using linear regression models.

Four characterized reduced-activity variants (including CYP2A6*12) accounted for 15–20% of variance in NMR

strong effect of CYP2A6 ... on NMR

population-attributable effect ... greater than that of the four functional variants frequently genotyped in Caucasians (CYP2A6*2, *4, *9, and *12)