ADH1B risk_factor_for PAU
Evidence from:
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Evidence (4 sources)
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.
(2020)
PMID:32451486
primary
four significant alcohol dehydrogenase genes ... were associated with expression ... indicating functional consequences of PAU-risk-associated variation.
confidence: 0.70
Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits.
(2020)
PMID:32451486
primary
Ten variants were previously identified ... located in or near the following genes: ADH1B ... and a novel ADH1B variant rs75967634 is GWS for PAU.
confidence: 0.96
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals.
(2023)
PMID:38062264
cited
ADH1B expression in putamen was associated with PAU by TWAS, indicating potential biological mechanisms for the association of ADH1B with PAU risk
confidence: 0.94
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals.
(2023)
PMID:38062264
cited
ADH1B ... showed association with PAU by incorporating brain chromatin interaction profiles.
confidence: 0.96