de novo variant risk_factor_for TD
Evidence from:
primary |
all sources
Evidence (6 sources)
de novo variant contributing TD risk
confidence: 0.96
significant excess of de novo damaging (LGD + Mis3) variants ... in TD (RR 1.37, 95% CI 1.11–1.69, p = 0.003)
confidence: 0.94
association of de novo LGD variants with TD (RR 1.97, 95% CI 1.03–3.68, p = 0.04)
confidence: 0.95
The enrichment of de novo damaging ... variants in TD ... mediates TD risk.
confidence: 0.95
estimate the number of genes contributing risk to TD, based on vulnerability to de novo damaging variants
confidence: 0.90
22.9% (95% CI 4.8 – 41.0%) of de novo damaging variants ... contribute risk to TD
confidence: 0.95